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4-Hydroxybenzoic acid and its Methyl- and Ethyl- esters, and their salts (INCI) 4-Hydroxybenzoic acid; CAS No. 99-96-7; Methylparaben; CAS No. 99-76-3; potassium ethylparaben; CAS No. 36457-19-9; potassium paraben; CAS No. 16782-08-4 sodium methylparaben; CAS No. 5026-62-0; sodium ethylparaben; CAS No. 35285-68-8; ethylparaben; CAS No. 120-47-8; sodium paraben; CAS No. 114-63-6; potassium methylparaben; CAS No. 26112-07- 2; calcium paraben; CAS No. 69959-44-0;

4-Hydroxybenzoic acid and its Methyl- and Ethyl- esters, and their salts (INCI) 4-Hydroxybenzoic acid; CAS No. 99-96-7; Methylparaben; CAS No. 99-76-3; potassium ethylparaben; CAS No. 36457-19-9; potassium paraben; CAS No. 16782-08-4 sodium methylparaben;

ASEAN Annex VI lists this record among preservatives allowed for cosmetic use. Member-state transition rules and deviations still require local verification.

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Regulatory decision and full conditions

Status
Permitted list with conditions
Legal role
Binding rule
Regulatory summary
ASEAN Annex VI lists this record among preservatives allowed for cosmetic use. Member-state transition rules and deviations still require local verification.
Conditions and restrictions
0.4% (as acid) for single ester 0.8% (as acid) for mixtures of esters

Substance identity

Official source name
4-Hydroxybenzoic acid and its Methyl- and Ethyl- esters, and their salts (INCI) 4-Hydroxybenzoic acid; CAS No. 99-96-7; Methylparaben; CAS No. 99-76-3; potassium ethylparaben; CAS No. 36457-19-9; potassium paraben; CAS No. 16782-08-4 sodium methylparaben; CAS No. 5026-62-0; sodium ethylparaben; CAS No. 35285-68-8; ethylparaben; CAS No. 120-47-8; sodium paraben; CAS No. 114-63-6; potassium methylparaben; CAS No. 26112-07- 2; calcium paraben; CAS No. 69959-44-0;
CAS
99-96-7; 99-76-3; 36457-19-9; 16782-08-4; 5026-62-0; 35285-68-8; 120-47-8; 114-63-6; 26112-07-2; 69959-44-0
EC
202-804-9
Identity mapping
cas_number
Linked ingredient
4-HYDROXYBENZOIC ACID
Search this identity across the siteCAS 99-96-7CAS 99-76-3CAS 36457-19-9CAS 16782-08-4CAS 5026-62-0CAS 35285-68-8CAS 120-47-8CAS 114-63-6CAS 26112-07-2CAS 69959-44-0EC 202-804-9

Linked CosIng identity data

Names and aliases

4-HYDROXYBENZOIC ACID

CosIng description: 4-hydroxybenzoic acid

EU inventory restriction note: V/12

Recorded cosmetic function: FRAGRANCE, PRESERVATIVE

Function pages:FRAGRANCE, PRESERVATIVE

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

5 market datasets

European Union

Positive-list entry with conditions

1 linked record · 1 with specific conditions

Open supporting record

Great Britain

Permitted list with conditions

1 linked record · 1 with specific conditions

Open supporting record

New Zealand

Permitted list with conditions

10 linked records · 10 with specific conditions

Open supporting record

ASEAN

Current record
Permitted list with conditions

1 linked record · 1 with specific conditions

Open supporting record
PubChem 2D chemical structure for CAS 114-63-6
CAS 114-63-6PubChem CID 16219477

Verified chemistry for CAS 114-63-6

Sodium 4-hydroxybenzoate

IUPAC name
sodium 4-hydroxybenzoate
Molecular formula
C7H5NaO3
Molecular weight
160.10 g/mol
Exact mass
160.01363830 Da
Monoisotopic mass
160.01363830 Da
Topological polar surface area
60.4 Ų
Molecular complexity
130.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Rotatable bonds
1
Heavy atoms
11
Covalent units
2

Names and synonyms reported to PubChem

Sodium p-hydroxybenzoate4-Hydroxybenzoic acid sodium saltsodium parabenp-Hydroxybenzoic acid sodium saltBenzoic acid, 4-hydroxy-, monosodium saltMonosodium p-hydroxybenzoateMonosodium 4-hydroxybenzoateBenzoic acid, 4-hydroxy-, sodium salt (1:1)
16 more reported names
EINECS 204-051-1p-hydroxybenzoic acid monosodium saltV6102T509BBENZOIC ACID, p-HYDROXY-, SODIUM SALTCHEBI:113449SODIUM 4-HYDROXYBENZOIC ACIDBENZOIC ACID, P-HYDROXY-, MONOSODIUM SALTRefChem:887100SODIUM PARABEN [INCI]sodium;4-hydroxybenzoateC7H5NaO3H0221UNII-V6102T509B4-Hydroxybenzoate sodiumsodium parahydroxybenzoate4-Hydroxybenzoic acid sodium
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1C(=O)[O-])O.[Na+]
InChI
InChI=1S/C7H6O3.Na/c8-6-3-1-5(2-4-6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
InChIKey
ZLVSYODPTJZFMK-UHFFFAOYSA-M

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match16219477

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 3.5% (3 of 86) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (96.5%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (96.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (95.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 86 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 3 of 86 reports by companies.; There are 5 notifications provided by 83 of 86 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Cosmetic Ingredient Review Conclusion: The CIR Expert Panel concluded that the following 20 parabens are safe in cosmetics in the present practices of use and concentration described in the safety assessment when the sum of the combined concentration of parabens in any given formulation does not exceed 0.8 %...Sodium Paraben... Source: Cosmetic Ingredient Review (CIR)
  • Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 120-47-8
CAS 120-47-8PubChem CID 8434

Verified chemistry for CAS 120-47-8

Ethylparaben

IUPAC name
ethyl 4-hydroxybenzoate
Molecular formula
C9H10O3
Molecular weight
166.17 g/mol
Exact mass
166.062994177 Da
Monoisotopic mass
166.062994177 Da
XLogP3
2.5
Topological polar surface area
46.5 Ų
Molecular complexity
148.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Rotatable bonds
3
Heavy atoms
12
Covalent units
1

Names and synonyms reported to PubChem

Ethyl parabenEthyl p-hydroxybenzoateTegosept EMycoctenEthyl parasept4-Hydroxybenzoic acid ethyl esterAseptoform ENipagin A
16 more reported names
EaseptolEthyl butexNapagin ANipazin ASolbrol ASobrol AEthyl parahydroxybenzoatep-Hydroxybenzoic acid ethyl esterEthyl p-oxybenzoateBonomold OEBenzoic acid, 4-hydroxy-, ethyl esterp-CarbethoxyphenolEthyl-p-hydroxybenzoateMekkings EAseptin AEthyl hydroxybenzoate
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
3
3D rings
1
3D hydrophobes
0
3D acceptor features
1
3D donor features
1
3D anionic centres
0
3D cationic centres
0
3D conformers
7
Effective 3D rotors
3.0
Machine-readable structure identifiers
SMILES
CCOC(=O)C1=CC=C(C=C1)O
InChI
InChI=1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3
InChIKey
NUVBSKCKDOMJSU-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8434

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 60.7% (811 of 1336) of all reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H304 (33.5%): May be fatal if swallowed and enters airways [Danger Aspiration hazard]; H315 (38.8%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (34%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (39.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P272, P280, P301+P316, P302+P352, P305+P351+P338, P321, P331, P332+P317, P333+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1336 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 811 of 1336 reports by companies.; There are 8 notifications provided by 525 of 1336 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Note: This chemical does not meet GHS hazard criteria for 100% (2 of 2) of all reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 2 of 2 companies. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2 reports by companies from 1 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 2 of 2 reports by companies.; There are 0 notifications provided by 0 of 2 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard] Source: Hazardous Substances Data Bank (HSDB)
  • Precautionary Statement Codes: P273, and P501 (click each P-code to see the statement) Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Conclusion: The CIR Expert Panel concluded that the following 20 parabens are safe in cosmetics in the present practices of use and concentration described in the safety assessment when the sum of the combined concentration of parabens in any given formulation does not exceed 0.8 %...Ehtylparaben.. Source: Cosmetic Ingredient Review (CIR)
  • Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: IDENTIFICATION AND USE: Ethylparaben forms small colorless crystals, or white powder. Ethylparaben inhibits the growth of fungi and bacteria and is used as a preservative for pharmaceuticals, adhesives, and various cosmetic preparations. HUMAN EXPOSURE AND TOXICITY: Ethylparaben was a skin irritant in man. It gave no evidence of sensitizing potential in a human study. The paraben esters as a generic class are rare sensitizers when applied to the intact skin of man. Application to the damaged skin is a more common cause of sensitization. A methyl:ethyl:propylparaben mixture has been shown on oral administration to exacerbate pre-existing skin complaints. ANIMAL STUDIES: Ethylparaben was an eye irritant in rabbits. A low acute oral toxicity has been demonstrated for ethylparaben in laboratory animals. Limited long-term studies in rats have also indicated a low toxicity and have generated no evidence of carcinogenic activity. Ethylparaben in the diet produced cell proliferation in the forestomach of rats. No evidence of mutagenicity was reported in limited Ames Bacterial tests. Ethylparaben did increase chromosomal aberrations in a Chinese Hamster ovary cell assay, but similar effects Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 20 was calculated for ethylparaben(SRC), using a log Kow of 2.47(1) and a regression derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values ranging from 119 to 209(2) indicate that ethylparaben is expected to have high to moderate mobility in soil(SRC). The pKa of ethylparaben is 8.34(3), indicating that this compound will partially exist in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of ethylparaben from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.8X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(5). Ethylparaben is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 9.3X10-5 mm Hg(SRC), determined from a fragment constant method(6). Half-lives of about 14 days and 3.5 days were measured in aerobic screening tests conducted with phenol- and cresol-acclimated sludge over 7 day and 1 day incubation periods(7,8), respectively, suggesting that biodegradation may be an important fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), Koc values ranging from 119 to 209(2), indicate that ethylparaben is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 4.8X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 20(SRC), from its log Kow of 2.47(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Half-lives of about 14 days and 3.5 days were measured in aerobic screening tests conducted with phenol- and cresol-acclimated sludge over 7 day and 1 day incubation periods(8,9), respectively, suggesting that biodegradation may be an important fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylparaben, which has an estimated vapor pressure of 9.3X10-5 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase ethylparaben is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be one day(SRC), calculated from its rate constant of 1.3X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase ethylparaben may be removed from the air by wet and dry deposition(SRC). Ethylparaben contains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 16782-08-4
CAS 16782-08-4PubChem CID 23672310

Verified chemistry for CAS 16782-08-4

Potassium Paraben

IUPAC name
potassium 4-hydroxybenzoate
Molecular formula
C7H5KO3
Molecular weight
176.21 g/mol
Exact mass
175.98757550 Da
Monoisotopic mass
175.98757550 Da
Topological polar surface area
60.4 Ų
Molecular complexity
130.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Rotatable bonds
1
Heavy atoms
11
Covalent units
2

Names and synonyms reported to PubChem

potassium p-hydroxybenzoateUNII-UHZ6Y0A8VRUHZ6Y0A8VREINECS 240-830-2MONOPOTASSIUM P-HYDROXYBENZOATE4-HYDROXYBENZOIC ACID POTASSIUM SALTP-HYDROXYBENZOIC ACID MONOPOTASSIUM SALTBENZOIC ACID, 4-HYDROXY-, MONOPOTASSIUM SALT
10 more reported names
BENZOIC ACID, P-HYDROXY-, MONOPOTASSIUM SALTBENZOIC ACID, 4-HYDROXY-, POTASSIUM SALT (1:1)RefChem:175568POTASSIUM PARABEN [INCI]potassium;4-hydroxybenzoatep-hydroxybenzoic acid potassium saltP-HYDROXYBENZOICACIDPOTASSIUMSALTpotassium parahydroxybenzoateMSK2535KSafinamide Impurity 45 Potassium Salt
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1C(=O)[O-])O.[K+]
InChI
InChI=1S/C7H6O3.K/c8-6-3-1-5(2-4-6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
InChIKey
DKGFIVSGQRBSOG-UHFFFAOYSA-M

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 26112-07-2
CAS 26112-07-2PubChem CID 23663677

Verified chemistry for CAS 26112-07-2

Potassium Methylparaben

IUPAC name
potassium 4-methoxycarbonylphenolate
Molecular formula
C8H7KO3
Molecular weight
190.24 g/mol
Exact mass
190.00322557 Da
Monoisotopic mass
190.00322557 Da
Topological polar surface area
49.4 Ų
Molecular complexity
141.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
2
Heavy atoms
12
Covalent units
2

Names and synonyms reported to PubChem

UNII-M64U971IB0M64U971IB0EINECS 247-464-2Methylparaben, potassium saltBenzoic acid, 4-hydroxy-, methyl ester, potassium salt4-Hydroxybenzoic acid, methyl ester, potassium saltMETHYL P-HYDROXYBENZOATE POTASSIUM SALTMETHYL 4-HYDROXYBENZOATE POTASSIUM SALT
12 more reported names
BENZOIC ACID, P-HYDROXY-, METHYL ESTER, POTASSIUM SALTBENZOIC ACID, 4-HYDROXY-, METHYL ESTER, POTASSIUM SALT (1:1)RefChem:175524POTASSIUM METHYLPARABEN [INCI]247-464-2Potassium methyl 4-oxidobenzoatepotassium;4-methoxycarbonylphenolateMETHYL 4-HYDROXYBENZOATE POTASSIUMpotassium 4-(methoxycarbonyl)phenolateMETHYL4-HYDROXYBENZOATEPOTASSIUMMSK2509KMOCBTMXJPWSHOD-UHFFFAOYSA-M
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
COC(=O)C1=CC=C(C=C1)[O-].[K+]
InChI
InChI=1S/C8H8O3.K/c1-11-8(10)6-2-4-7(9)5-3-6;/h2-5,9H,1H3;/q;+1/p-1
InChIKey
MOCBTMXJPWSHOD-UHFFFAOYSA-M

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 35285-68-8
CAS 35285-68-8PubChem CID 52913806

Verified chemistry for CAS 35285-68-8

SODIUM ETHYL p-HYDROXYBENZOATE

Molecular formula
C9H10NaO3
Molecular weight
189.16 g/mol
Exact mass
189.05276346 Da
Monoisotopic mass
189.05276346 Da
Topological polar surface area
46.5 Ų
Molecular complexity
148.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Rotatable bonds
3
Heavy atoms
13
Covalent units
2

Names and synonyms reported to PubChem

RefChem:1098791Benzoic acid, 4-hydroxy-, ethyl ester, sodium saltp-Hydroxybenzoic acid ethyl ester sodium saltSodium Ethyl Parabenp-Hydroxybenzoic acid ethyl ester sodium salt;Sodium 2-ethyl-4-hydroxybenzoate
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
CCOC(=O)C1=CC=C(C=C1)O.[Na]
InChI
InChI=1S/C9H10O3.Na/c1-2-12-9(11)7-3-5-8(10)6-4-7;/h3-6,10H,2H2,1H3;
InChIKey
HLEKLAHSVAPCPF-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 36457-19-9
CAS 36457-19-9PubChem CID 23696798

Verified chemistry for CAS 36457-19-9

Potassium Ethylparaben

IUPAC name
potassium 4-ethoxycarbonylphenolate
Molecular formula
C9H9KO3
Molecular weight
204.26 g/mol
Exact mass
204.01887563 Da
Monoisotopic mass
204.01887563 Da
Topological polar surface area
49.4 Ų
Molecular complexity
153.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
3
Heavy atoms
13
Covalent units
2

Names and synonyms reported to PubChem

ethylparaben potassiumUNII-528JBB2994EINECS 253-048-1528JBB2994ETHYL P-HYDROXYBENZOATE POTASSIUM SALTP-HYDROXYBENZOIC ACID ETHYL ESTER POTASSIUM SALTRefChem:175473POTASSIUM ETHYLPARABEN [INCI]
9 more reported names
BENZOIC ACID, 4-HYDROXY-, ETHYL ESTER, POTASSIUM SALT (1:1)Potassium ethyl 4-oxidobenzoatepotassium;4-ethoxycarbonylphenolateBenzoic acid, 4-hydroxy-, ethyl ester, potassium saltMSK2510KHFTYFFXNUVBSII-UHFFFAOYSA-MPotassium 4-(ethoxycarbonyl)phenolateETHYL 4-HYDROXYBENZOATE POTASSIUM SALTPotassium Ethyl-p-hydroxyl Benzoate Solution, 100pm
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
CCOC(=O)C1=CC=C(C=C1)[O-].[K+]
InChI
InChI=1S/C9H10O3.K/c1-2-12-9(11)7-3-5-8(10)6-4-7;/h3-6,10H,2H2,1H3;/q;+1/p-1
InChIKey
HFTYFFXNUVBSII-UHFFFAOYSA-M

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 5026-62-0
CAS 5026-62-0PubChem CID 23663626

Verified chemistry for CAS 5026-62-0

Methylparaben Sodium

IUPAC name
sodium 4-methoxycarbonylphenolate
Molecular formula
C8H7NaO3
Molecular weight
174.13 g/mol
Exact mass
174.02928836 Da
Monoisotopic mass
174.02928836 Da
Topological polar surface area
49.4 Ų
Molecular complexity
141.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Rotatable bonds
2
Heavy atoms
12
Covalent units
2

Names and synonyms reported to PubChem

Paratexin msParidol mnaNipagin m sodiumsodium methyl parabenSolbrol m sodium saltCR6K9C2NHKMethylparaben, sodium saltNs 3500s
16 more reported names
RefChem:158282225-714-1Sodium 4-(methoxycarbonyl)phenolateSodium methylparabenMethyl 4-hydroxybenzoate, sodium saltMethyl 4-hydroxybenzoate sodium saltSodium 4-carbomethoxyphenolateSodium methyl p-hydroxybenzoateMethylparaben sodium saltsodium;4-methoxycarbonylphenolateUNII-CR6K9C2NHKSodium Methyl ParahydroxybenzoateSodium methylparaben, 99%4-Hydroxybenzoic acid-methyl ester sodiumPreserval MSSolparol
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
COC(=O)C1=CC=C(C=C1)[O-].[Na+]
InChI
InChI=1S/C8H8O3.Na/c1-11-8(10)6-2-4-7(9)5-3-6;/h2-5,9H,1H3;/q;+1/p-1
InChIKey
PESXGULMKCKJCC-UHFFFAOYSA-M

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 69959-44-0
CAS 69959-44-0PubChem CID 54686127

Verified chemistry for CAS 69959-44-0

Calcium bis(4-hydroxybenzoate)

IUPAC name
calcium bis(4-carboxyphenolate)
Molecular formula
C14H10CaO6
Molecular weight
314.30 g/mol
Exact mass
314.0103289 Da
Monoisotopic mass
314.0103289 Da
Topological polar surface area
121.0 Ų
Molecular complexity
125.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
6
Rotatable bonds
2
Heavy atoms
21
Covalent units
3

Names and synonyms reported to PubChem

EINECS 274-235-4RefChem:122778274-235-4calcium;4-carboxyphenolateMSK2535CaCalcium Bis(4-Hydroxybenzoate) Solution, 100pm
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1C(=O)O)[O-].C1=CC(=CC=C1C(=O)O)[O-].[Ca+2]
InChI
InChI=1S/2C7H6O3.Ca/c2*8-6-3-1-5(2-4-6)7(9)10;/h2*1-4,8H,(H,9,10);/q;;+2/p-2
InChIKey
DTFQOFKRUDOJCR-UHFFFAOYSA-L

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 99-76-3
CAS 99-76-3PubChem CID 7456

Verified chemistry for CAS 99-76-3

Methylparaben

Methylparaben is a 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. It is the most frequently used antimicrobial preservative in cosmetics. It occurs naturally in several fruits, particularly in blueberries. It has a role as an antifungal agent, a neuroprotective agent, an antimicrobial food preservative and a plant metabolite. — ChEBI

IUPAC name
methyl 4-hydroxybenzoate
Molecular formula
C8H8O3
Molecular weight
152.15 g/mol
Exact mass
152.047344113 Da
Monoisotopic mass
152.047344113 Da
XLogP3
2.0
Topological polar surface area
46.5 Ų
Molecular complexity
136.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Rotatable bonds
2
Heavy atoms
11
Covalent units
1

Names and synonyms reported to PubChem

Methyl parabenMethyl p-hydroxybenzoateNipaginTegosept MMoldexMaseptolMethyl parahydroxybenzoatep-Hydroxybenzoic acid methyl ester
16 more reported names
Preserval MPreservalMetabenMethabenMetoxydeParidolSolbrolSeptosMethyl parasept4-Hydroxybenzoic acid methyl esterMethyl butexMethyl chemoseptp-Methoxycarbonylphenolp-CarbomethoxyphenolNipagin MBenzoic acid, 4-hydroxy-, methyl ester
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
3
3D rings
1
3D hydrophobes
0
3D acceptor features
1
3D donor features
1
3D anionic centres
0
3D cationic centres
0
3D conformers
2
Effective 3D rotors
2.0
Machine-readable structure identifiers
SMILES
COC(=O)C1=CC=C(C=C1)O
InChI
InChI=1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3
InChIKey
LXCFILQKKLGQFO-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 99-96-7
CAS 99-96-7PubChem CID 135

Verified chemistry for CAS 99-96-7

4-Hydroxybenzoic Acid

4-hydroxybenzoic acid is a monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring. It has a role as a plant metabolite and an algal metabolite. It is a conjugate acid of a 4-hydroxybenzoate. — ChEBI

IUPAC name
4-hydroxybenzoic acid
Molecular formula
C7H6O3
Molecular weight
138.12 g/mol
Exact mass
138.031694049 Da
Monoisotopic mass
138.031694049 Da
XLogP3
1.6
Topological polar surface area
57.5 Ų
Molecular complexity
125.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Rotatable bonds
1
Heavy atoms
10
Covalent units
1

Names and synonyms reported to PubChem

p-Hydroxybenzoic acidp-Salicylic acid4-CarboxyphenolBenzoic acid, 4-hydroxy-Benzoic acid, p-hydroxy-para-Hydroxybenzoic acidp-OxybenzoesaureJG8Z55Y12H
16 more reported names
NSC-4961FEMA NO. 3986CHEBI:30763CHEBI:17879RefChem:25955202-804-94-Hydroxybenzoatep-carboxyphenol4-hydroxy benzoic acidHydroxybenzoic acid4-HydroxybenzoesaeureParaben-acidp-Oxybenzoesaure [German]p-hydroxy benzoic acid4-hydroxy-benzoic acidAcido p-idrossibenzoico [Italian]
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
1
3D hydrophobes
0
3D acceptor features
2
3D donor features
1
3D anionic centres
1
3D cationic centres
0
3D conformers
2
Effective 3D rotors
1.0
Machine-readable structure identifiers
SMILES
C1=CC(=CC=C1C(=O)O)O
InChI
InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)
InChIKey
FJKROLUGYXJWQN-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
ASEAN Cosmetic Directive annexes
Source reference
ASEAN Annex VI, reference 12
Source record ID
VI-12
Source version
2026-1
Source language
English
Translation status
Original is English
Source updated
2026-06-22
Snapshot checked
2026-08-30 04:44 UTC
Validation method
pdfplumber ruled-table extraction with per-annex reviewed counts
SHA-256
ffad59f6c01a92c82042c54203ee14969425c2a82bd04c2f4012ff82513e69f1

Registered dataset notes

Dataset coverage
Banned, restricted and positive-list substances under the harmonised ASEAN framework
Authority note
Regional directive; member-state transitions and deviations still require local verification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2224
current ASEAN records
247
records marked Permitted list with conditions
2224
records from this source version
1930
market records with CAS identity

Status distribution

Permitted list with conditions: 247Prohibited: 1728Restricted: 249

Condition text is present on 462 of 2224 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

ASEAN market context

Complete regional annex dataset

Coverage version: ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026

Annexes II, III, IV, VI and VII covering prohibited, restricted and positive-list substances.

Verification checklist

  1. Search all ACD annexes by name and identifiers.
  2. Apply product type, maximum level and warning conditions.
  3. Confirm the target member state's adoption and transition date.
  4. Complete the local notification and responsible-company requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “4-Hydroxybenzoic acid and its Methyl- and Ethyl- esters, and their salts (INCI) 4-Hydroxybenzoic acid; CAS No. 99-96-7; Methylparaben; CAS No. 99-76-3; potassium ethylparaben; CAS No. 36457-19-9; potassium paraben; CAS No. 16782-08-4 sodium methylparaben; CAS No. 5026-62-0; sodium ethylparaben; CAS No. 35285-68-8; ethylparaben; CAS No. 120-47-8; sodium paraben; CAS No. 114-63-6; potassium methylparaben; CAS No. 26112-07- 2; calcium paraben; CAS No. 69959-44-0;” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search all ACD annexes by name and identifiers.
  3. Apply product type, maximum level and warning conditions.
  4. Confirm the target member state's adoption and transition date.
  5. Complete the local notification and responsible-company requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This identity appears on a market positive list for the list function represented by the source record. Confirm that the intended function and product use fall within the list scope and every stated condition.

Positive-list presence is purpose-specific and is not blanket approval for every cosmetic use. Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.

The record cites ASEAN Annex VI, reference 12, source version 2026-1. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

4-Hydroxybenzoic acid and its Methyl- and Ethyl- esters, and their salts (INCI) 4-Hydroxybenzoic acid; CAS No. 99-96-7; Methylparaben; CAS No. 99-76-3; potassium ethylparaben; CAS No. 36457-19-9; potassium paraben; CAS No. 16782-08-4 sodium methylparaben; CAS No. 5026-62-0; sodium ethylparaben; CAS No. 35285-68-8; ethylparaben; CAS No. 120-47-8; sodium paraben; CAS No. 114-63-6; potassium methylparaben; CAS No. 26112-07- 2; calcium paraben; CAS No. 69959-44-0;. ASEAN Annex VI, reference 12. ASEAN. Source version 2026-1. CosIng Checker regulatory record: https://cosingchecker.com/regulations/asean/records/4270/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for ASEAN

This identity appears on a market positive list for the list function represented by the source record.

Confirm that the intended function and product use fall within the list scope and every stated condition.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Permitted list with conditions
  • Legal role: Binding rule
  • Source version: 2026-1

What it does not prove

Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source