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ProhibitedBinding ruleASEANOriginal is EnglishOfficial-source import checked

Butane, if it contains ≥ 0.1 % w/w Butadiene

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

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Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
Butane, if it contains ≥ 0.1 % w/w Butadiene
CAS
106-97-8
EC
203-448-7
Identity mapping
cas_number
Linked ingredient
BUTANE
Search this identity across the siteCAS 106-97-8EC 203-448-7

Linked CosIng identity data

Names and aliases

BUTANEbutane

CosIng description: Butane, less than 0.1% w/w butadiene

Recorded cosmetic function: PROPELLANT

Function pages:PROPELLANT

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

9 market datasets
PubChem 2D chemical structure for CAS 106-97-8
CAS 106-97-8PubChem CID 7843

Verified chemistry for CAS 106-97-8

Butane

IUPAC name
butane
Molecular formula
C4H10
Molecular weight
58.12 g/mol
Exact mass
58.078250319 Da
Monoisotopic mass
58.078250319 Da
XLogP3
2.9
Topological polar surface area
0.0 Ų
Molecular complexity
2.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Rotatable bonds
1
Heavy atoms
4
Covalent units
1

Names and synonyms reported to PubChem

n-ButaneDiethylMethylethylmethaneButanenButaniButyl hydrideHC 600A 21 (lowing agent)
16 more reported names
R 600n-Butan6LV4FOR43RE943an-C4H10INS NO.943INS-943E-943R-600CHEBI:37808E 943aE-943anormal-ButaneRefChem:6622203-448-7butan
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
2
3D rings
0
3D hydrophobes
2
3D acceptor features
0
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
3
Effective 3D rotors
1.0
Machine-readable structure identifiers
SMILES
CCCC
InChI
InChI=1S/C4H10/c1-3-4-2/h3-4H2,1-2H3
InChIKey
IJDNQMDRQITEOD-UHFFFAOYSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:37808

butane

A straight chain alkane composed of 4 carbon atoms.

Formula
C4H10
Average mass
58.124 g/mol
Monoisotopic mass
58.07825 Da
Formal charge
0
  • alkane — is a (CHEBI:18310)
  • gas molecular entity — is a (CHEBI:138675)
  • refrigerant — has role (CHEBI:78433)
  • food propellant — has role (CHEBI:78017)
  • antihypertensive agent — has role (CHEBI:35674)
  • refrigerant — has role (CHEBI:78433)
  • food propellant — has role (CHEBI:78017)
  • antihypertensive agent — has role (CHEBI:35674)
  • alkane — is a (CHEBI:18310)
  • gas molecular entity — is a (CHEBI:138675)
Additional curated names
butaneE-943E 943aE-943aE943an-Butann-butanen-C4H10HC 600Hc 600 (hydrocarbon)INS-943INS NO.943N-BUTANER 600R-600R 600 (alkane)
Cross-references from this source
  • CAS: 106-97-8 — NIST Chemistry WebBook
  • CAS: 106-97-8 — ChemIDplus
  • REGISTRY_NUMBER: 1148 — Gmelin
  • REGISTRY_NUMBER: 969129 — Reaxys
  • REGISTRY_NUMBER: 969129 — Beilstein
  • MANUAL_X_REF: Butane — Wikipedia
  • MANUAL_X_REF: NBU — PDBeChem

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2020-11-13. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7843

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.; SKIN: CAUTION: Exposure of skin to compressed gases may result in freezing of the skin. Treatment for frostbite may be necessary. Remove the victim from the source of contamination. IMMEDIATELY wash affected areas gently with COLD water (and soap, if necessary) while removing and isolating all contaminated clothing. Dry carefully with clean, soft towels. If symptoms such as inflammation or irritation develop, IMMEDIATELY call a physician or go to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper resp Source: CAMEO Chemicals
  • ERG2024, Guide 115 (Butane): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Frostbite - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.; Skin: Frostbite - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.; Breathing: Respiratory support Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Health Effects: Butane targets the central nervous system and cardiovascular system. Inhalation of butane can cause frostbite which can result in death from asphyxiation and ventricular fibrillation. (L1283, L1284) Source: Toxin and Toxin Target Database (T3DB)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: n-Butane is a colorless, flammable gas at room temperature. It occurs as a component in natural gas from which it is refined. n-Butane is used as fuel, refrigerant and aerosol propellant. The acute toxicity of n-butane has been studied after inhalation exposure in experimental animals. LC50 (4h) was 658 mg/l in rats and LC50 (2h) was 680 mg/l in mice. In dogs, lethal concentrations ranged from 474 to 592 mg/l. A concentration of 308 mg/l caused light anesthesia in mice within 25 minutes, and an exposure to 521 mg/l had similar effect within one minute. n-Butane ... sensitiz/ed/ the myocardium to epinephrine-induced cardiac arrhythmias in dogs after inhalation. No reports on acute toxicity of n-butane in experimental animals by other administration routes were located in the available literature. In a 21-day inhalation toxicity study of a mixture of n-butane, isobutane, n-penta and isopentane, containing 25% of each, the absence of toxicity was evident up to 11.8 mg/l which was the highest concentration tested. The study was performed in Sprague-Dawley rats which were exposed 6 hours per day over three weeks for a total of 15 exposures. No long-term studies using pure n-butane were Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Butane is a simple asphyxiant and causes toxicity by displacing oxygen. It also affects the central nervous system by enhancing glycine receptors and inhibiting N-methyl-d-aspartate (NMDA) receptors. (L1284, A352) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: An estimated BCF of 33 was calculated for n-butane(SRC), using a log Kow of 2.89(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a log Kow of 2.89(2) and a regression-derived equation(3), indicates that n-butane is expected to have high mobility in soil(SRC). Volatilization of n-butane from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.95 atm-cu m/mole(SRC), derived from its vapor pressure, 1820 mm Hg(4) and water solubility, 61.2 mg/L(5). The potential for volatilization of n-butane from dry soil surfaces may exist(SRC) based upon its vapor pressure(4). While volatilization from soil surfaces is expected to be the predominant fate process of n-butane released to soil, this compound is also susceptible to biodegradation(SRC). A biodegradation rate of 1.8 mg C/day/kg dry soil(6) suggests that biodegradation may be an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a log Kow of 2.89(2) and a regression-derived equation(3), indicates that n-butane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon an estimated Henry's Law constant of 0.95 atm-cu m/mole(SRC), derived from its vapor pressure, 1820 mm Hg(5) and water solubility, 61.2 mg/L(6). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 50 minutes and 3 days, respectively(SRC). According to a classification scheme(7), an estimated BCF of 40(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Photolysis(8) or hydrolysis(4) of n-butane in aquatic systems are not expected to be important environmental fate process in water(SRC). While volatilization from water surfaces is expected to be the predominant fate process in water, this compound is also susceptible to biodegradation(SRC). Complete biodegradation was reported in 34 days using an activated sludge Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), n-butane, which has a vapor pressure of 1820 mm Hg at 25 °C(2), is expected to exist solely as a gas in the ambient atmosphere. Gas-phase n-butane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6.3 days(SRC), calculated from its rate constant of 2.54X10-12 cu cm/molecule-sec at 25 deg(3). Experimental data showed that 7.7% of the n-butane fraction in a dark chamber reacted with nitrogen oxide to form the corresponding alkyl nitrate(4,5), suggesting nighttime reactions with radical species and nitrogen oxides may contribute to the atmospheric transformation of n-butane(SRC). Based on data for iso-octane and n-hexane(6), n-butane is not expected to absorb UV light at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Intermediate; Propellants, non-motive (blowing agents); Filler; Not Known or Reasonably Ascertainable; Fuels and fuel additives; Fuel; Fuel agents; Other Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Fuels and fuel additives; Processing aids not otherwise specified; Fuel; Fuel agents; Abrasives; Other; Intermediate; Propellants, non-motive (blowing agents); Not Known or Reasonably Ascertainable; Sealant (barrier) Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
ASEAN Cosmetic Directive annexes
Source reference
ASEAN Annex II, reference 465
Source record ID
II-465
Source version
2026-1
Source language
English
Translation status
Original is English
Source updated
2026-06-22
Snapshot checked
2026-08-30 04:44 UTC
Validation method
pdfplumber ruled-table extraction with per-annex reviewed counts
SHA-256
ffad59f6c01a92c82042c54203ee14969425c2a82bd04c2f4012ff82513e69f1

Registered dataset notes

Dataset coverage
Banned, restricted and positive-list substances under the harmonised ASEAN framework
Authority note
Regional directive; member-state transitions and deviations still require local verification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2224
current ASEAN records
1728
records marked Prohibited
2224
records from this source version
1930
market records with CAS identity

Status distribution

Permitted list with conditions: 247Prohibited: 1728Restricted: 249

Condition text is present on 462 of 2224 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

ASEAN market context

Complete regional annex dataset

Coverage version: ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026

Annexes II, III, IV, VI and VII covering prohibited, restricted and positive-list substances.

Verification checklist

  1. Search all ACD annexes by name and identifiers.
  2. Apply product type, maximum level and warning conditions.
  3. Confirm the target member state's adoption and transition date.
  4. Complete the local notification and responsible-company requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Butane, if it contains ≥ 0.1 % w/w Butadiene” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search all ACD annexes by name and identifiers.
  3. Apply product type, maximum level and warning conditions.
  4. Confirm the target member state's adoption and transition date.
  5. Complete the local notification and responsible-company requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textNot present in source row
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.

The record cites ASEAN Annex II, reference 465, source version 2026-1. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Butane, if it contains ≥ 0.1 % w/w Butadiene. ASEAN Annex II, reference 465. ASEAN. Source version 2026-1. CosIng Checker regulatory record: https://cosingchecker.com/regulations/asean/records/2606/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for ASEAN

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: 2026-1

What it does not prove

Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source