Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
CAS 1 record

CAS 106-97-8

CAS 106-97-8 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

Check this CAS numberBrowse annexes

Chemical identity and properties

PubChem 2D chemical structure for CAS 106-97-8
CAS 106-97-8PubChem CID 7843

Butane

Butane is a straight chain alkane composed of 4 carbon atoms. It has a role as a food propellant and a refrigerant. It is a gas molecular entity and an alkane. — ChEBI

IUPAC name
butane
Molecular formula
C4H10
Molecular weight
58.12 g/mol
Exact mass
58.078250319 Da
XLogP3
2.9
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Covalent units
1
Defined stereocentres
0

Also known as

n-ButaneDiethylMethylethylmethaneButanenButaniButyl hydrideHC 600A 21 (lowing agent)
16 more reported names
R 600n-Butan6LV4FOR43RE943an-C4H10INS NO.943INS-943E-943R-600CHEBI:37808E 943aE-943anormal-ButaneRefChem:6622203-448-7butan
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:37808

butane

A straight chain alkane composed of 4 carbon atoms.

Formula
C4H10
Average mass
58.124 g/mol
Monoisotopic mass
58.07825 Da
Formal charge
0
  • alkane — is a (CHEBI:18310)
  • gas molecular entity — is a (CHEBI:138675)
  • refrigerant — has role (CHEBI:78433)
  • food propellant — has role (CHEBI:78017)
  • antihypertensive agent — has role (CHEBI:35674)
  • refrigerant — has role (CHEBI:78433)
  • food propellant — has role (CHEBI:78017)
  • antihypertensive agent — has role (CHEBI:35674)
  • alkane — is a (CHEBI:18310)
  • gas molecular entity — is a (CHEBI:138675)
Additional curated names
butaneE-943E 943aE-943aE943an-Butann-butanen-C4H10HC 600Hc 600 (hydrocarbon)INS-943INS NO.943N-BUTANER 600R-600R 600 (alkane)
Cross-references from this source
  • CAS: 106-97-8 — NIST Chemistry WebBook
  • CAS: 106-97-8 — ChemIDplus
  • REGISTRY_NUMBER: 1148 — Gmelin
  • REGISTRY_NUMBER: 969129 — Reaxys
  • REGISTRY_NUMBER: 969129 — Beilstein
  • MANUAL_X_REF: Butane — Wikipedia
  • MANUAL_X_REF: NBU — PDBeChem

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2020-11-13. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7843

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.; SKIN: CAUTION: Exposure of skin to compressed gases may result in freezing of the skin. Treatment for frostbite may be necessary. Remove the victim from the source of contamination. IMMEDIATELY wash affected areas gently with COLD water (and soap, if necessary) while removing and isolating all contaminated clothing. Dry carefully with clean, soft towels. If symptoms such as inflammation or irritation develop, IMMEDIATELY call a physician or go to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper resp Source: CAMEO Chemicals
  • ERG2024, Guide 115 (Butane): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Frostbite - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.; Skin: Frostbite - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.; Breathing: Respiratory support Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Health Effects: Butane targets the central nervous system and cardiovascular system. Inhalation of butane can cause frostbite which can result in death from asphyxiation and ventricular fibrillation. (L1283, L1284) Source: Toxin and Toxin Target Database (T3DB)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: n-Butane is a colorless, flammable gas at room temperature. It occurs as a component in natural gas from which it is refined. n-Butane is used as fuel, refrigerant and aerosol propellant. The acute toxicity of n-butane has been studied after inhalation exposure in experimental animals. LC50 (4h) was 658 mg/l in rats and LC50 (2h) was 680 mg/l in mice. In dogs, lethal concentrations ranged from 474 to 592 mg/l. A concentration of 308 mg/l caused light anesthesia in mice within 25 minutes, and an exposure to 521 mg/l had similar effect within one minute. n-Butane ... sensitiz/ed/ the myocardium to epinephrine-induced cardiac arrhythmias in dogs after inhalation. No reports on acute toxicity of n-butane in experimental animals by other administration routes were located in the available literature. In a 21-day inhalation toxicity study of a mixture of n-butane, isobutane, n-penta and isopentane, containing 25% of each, the absence of toxicity was evident up to 11.8 mg/l which was the highest concentration tested. The study was performed in Sprague-Dawley rats which were exposed 6 hours per day over three weeks for a total of 15 exposures. No long-term studies using pure n-butane were Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Butane is a simple asphyxiant and causes toxicity by displacing oxygen. It also affects the central nervous system by enhancing glycine receptors and inhibiting N-methyl-d-aspartate (NMDA) receptors. (L1284, A352) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: An estimated BCF of 33 was calculated for n-butane(SRC), using a log Kow of 2.89(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a log Kow of 2.89(2) and a regression-derived equation(3), indicates that n-butane is expected to have high mobility in soil(SRC). Volatilization of n-butane from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.95 atm-cu m/mole(SRC), derived from its vapor pressure, 1820 mm Hg(4) and water solubility, 61.2 mg/L(5). The potential for volatilization of n-butane from dry soil surfaces may exist(SRC) based upon its vapor pressure(4). While volatilization from soil surfaces is expected to be the predominant fate process of n-butane released to soil, this compound is also susceptible to biodegradation(SRC). A biodegradation rate of 1.8 mg C/day/kg dry soil(6) suggests that biodegradation may be an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a log Kow of 2.89(2) and a regression-derived equation(3), indicates that n-butane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon an estimated Henry's Law constant of 0.95 atm-cu m/mole(SRC), derived from its vapor pressure, 1820 mm Hg(5) and water solubility, 61.2 mg/L(6). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 50 minutes and 3 days, respectively(SRC). According to a classification scheme(7), an estimated BCF of 40(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Photolysis(8) or hydrolysis(4) of n-butane in aquatic systems are not expected to be important environmental fate process in water(SRC). While volatilization from water surfaces is expected to be the predominant fate process in water, this compound is also susceptible to biodegradation(SRC). Complete biodegradation was reported in 34 days using an activated sludge Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), n-butane, which has a vapor pressure of 1820 mm Hg at 25 °C(2), is expected to exist solely as a gas in the ambient atmosphere. Gas-phase n-butane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6.3 days(SRC), calculated from its rate constant of 2.54X10-12 cu cm/molecule-sec at 25 deg(3). Experimental data showed that 7.7% of the n-butane fraction in a dark chamber reacted with nitrogen oxide to form the corresponding alkyl nitrate(4,5), suggesting nighttime reactions with radical species and nitrogen oxides may contribute to the atmospheric transformation of n-butane(SRC). Based on data for iso-octane and n-hexane(6), n-butane is not expected to absorb UV light at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Intermediate; Propellants, non-motive (blowing agents); Filler; Not Known or Reasonably Ascertainable; Fuels and fuel additives; Fuel; Fuel agents; Other Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Fuels and fuel additives; Processing aids not otherwise specified; Fuel; Fuel agents; Abrasives; Other; Intermediate; Propellants, non-motive (blowing agents); Not Known or Reasonably Ascertainable; Sealant (barrier) Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 106-97-8

1 total

How CAS 106-97-8 is used on this site

CAS 106-97-8 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 106-97-8 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 106-97-8 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.
Check this CAS number

Tools & next steps

Check your formula

Scan a full INCI list, then use CAS 106-97-8 to cross-check any supplier documents behind the matched substances.

INCI Checker

Browse annexes

Browse all EU cosmetic regulation annexes by category.

All annexes

Search by name

Search for INCI names, aliases or related identifiers that sit alongside CAS 106-97-8 in your documentation.

Search