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CAS 491-80-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 9214501/10/2014

GENISTEIN METHYL ETHER

Biochanin A,4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-methoxyphenyl)-

GENISTEIN METHYL ETHER is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 491-80-5

CAS 491-80-5PubChem CID 5280373

Biochanin A

Biochanin A is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, an EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor, a plant metabolite and a phytoestrogen. It is a member of 4'-methoxyisoflavones and a member of 7-hydroxyisoflavones. It is a conjugate acid of a biochanin A(1-). — ChEBI

IUPAC name: 5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one

Molecular formula: C16H12O5
Molecular weight: 284.26 g/mol
Exact mass: 284.06847348 Da
XLogP3: 3.0
Topological polar surface area: 76.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 0

Also known as

Biochanin5,7-Dihydroxy-4'-methoxyisoflavone4'-Methylgenistein5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-oneolmelinPratensolBiochanine AGenistein 4-methyl ether

16 more reported names

Biochanin-A5,7-Dihydroxy-3-p-methoxyphenyl-4H-chromen-4-oneNSC-123538CHEBI:17574U13J6U390T5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-oneGenistein 4-MethyletherRefChem:29990207-744-7CHEBI:86004H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-methoxyphenyl)-5,7-Dihydrox -4'-methoxyisoflavoneIsoflavone, 5,7-dihydroxy-4'-methoxy-Biochanin A (Standard)5,7-dihydroxy-4'-methoxy-Isoflavone4'-Methoxy-5,7-dihydroxy isoflavone

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:17574
ChEMBL:CHEMBL131921
EPA DTXSID:DTXSID1022394
PubMed:39177155
PubMed:38764152
PubMed:38648921
PubMed:38266663
PubMed:37057715
PubMed:37016276
PubMed:35547012
PubMed:35338989
PubMed:34848279
PubMed:34217736
PubMed:33410021
PubMed:33049310

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for GENISTEIN METHYL ETHER

INCI name

GENISTEIN METHYL ETHER

Description

Biochanin A,4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-methoxyphenyl)-

Record provenance

Inventory reference: 92145
Imported identity: GENISTEIN METHYL ETHER
Source update: 01/10/2014

European Commission CosIng source notes

Annex records for GENISTEIN METHYL ETHER

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Key data

CAS

491-80-5

—

Restriction

—

Function

HUMECTANT: Retaining and/or preserving the moisture in a product during use.
SKIN CONDITIONING: Maintaining the skin in good condition.
SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#10877 · GENISTEIN METHYL ETHER

Ingredients with overlapping formulation functions

GARCINIA SUBELLIPTICA LEAF EXTRACTHUMECTANT, SKIN CONDITIONING

GARDENIA JASMINOIDES FRUIT WATERHUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

GELIDIUM AMANSII OLIGOSACCHARIDESHUMECTANT, SKIN CONDITIONING

GELIDIUM CARTILAGINEUM/GRACILARIA VERRUCOSA/PORPHYRA YEZOENSIS EXTRACTFILM FORMING, HUMECTANT, SKIN CONDITIONING, VISCOSITY CONTROLLING

GENTIANA MACROPHYLLA ROOT EXTRACTHUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

GENTIANA SCABRA EXTRACTHUMECTANT, SKIN CONDITIONING

GENTIANA URNULA FLOWER EXTRACTHUMECTANT

GERANIUM SIBIRICUM EXTRACTHAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How GENISTEIN METHYL ETHER appears in the CosIng inventory

The CosIng inventory lists GENISTEIN METHYL ETHER as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

GENISTEIN METHYL ETHER is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

GENISTEIN METHYL ETHER is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, GENISTEIN METHYL ETHER carries the following function designation(s):

CAS 491-80-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for GENISTEIN METHYL ETHER

This page reproduces the CosIng inventory entry for GENISTEIN METHYL ETHER from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research GENISTEIN METHYL ETHER and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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