What does the restriction note for TROMETHAMINE mean?

The restriction field for TROMETHAMINE reads: III/61. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 77-86-1?

CAS 77-86-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains TROMETHAMINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8043815/10/2010

TROMETHAMINE

1,3-Propanediol, 2-amino-2-(hydroxymethyl)-

TROMETHAMINE is linked to 1 EU annex record on this page. Inventory note: III/61.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Restricted entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 77-86-1

CAS 77-86-1PubChem CID 6503

Tris(hydroxymethyl)aminomethane

Tris is a primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 79; pKa = 8.3 at 20 C; pKa = 7.82 at 37 C. It has a role as a buffer. It is a triol and a primary amino compound. It is a conjugate base of a member of Htris. — ChEBI

IUPAC name: 2-amino-2-(hydroxymethyl)propane-1,3-diol

Molecular formula: C4H11NO3
Molecular weight: 121.14 g/mol
Exact mass: 121.07389321 Da
XLogP3: -2.9
Topological polar surface area: 86.7 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

TrometamolTROMETHAMINEThamTrisamine2-Amino-2-(hydroxymethyl)-1,3-propanediolTris bufferTromethaneTris-base

16 more reported names

TrisaminolPehanormTalatrolTutofusin trisTris-sterilAddex-tham1,3-Propanediol, 2-amino-2-(hydroxymethyl)-TrispufferTrimethylolaminomethaneTris AminoTris, free baseAminotrimethylolmethaneAminotris(hydroxymethyl)methaneTris(hydroxymethyl)methylamineTHAM-ETris (buffering agent)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:9754
ChEMBL:CHEMBL1200391
EPA DTXSID:DTXSID2023723
PubMed:23107141
PubMed:23054718
PubMed:23037841
PubMed:23032750
PubMed:23016141
PubMed:23016110
PubMed:23011048
PubMed:23010469
PubMed:22990964
PubMed:22989297
PubMed:22975122
PubMed:22945490

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TROMETHAMINE

INCI name

TROMETHAMINE

INN name

trometamol

Description

1,3-Propanediol, 2-amino-2-(hydroxymethyl)-

Record provenance

Inventory reference: 80438
Imported identity: TROMETHAMINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for TROMETHAMINE

Annex III Restriction reference

Entry 61

Monoalkylamines, monoalkanolamines and their salts

Key data

CAS

77-86-1

201-064-4

Restriction

III/61

Function

BUFFERING: Stabilising the pH of an aqueous medium in a narrow range even if an acid or base is added. Altering and/or maintaining a cosmetic product's pH at the desired level.
FRAGRANCE: Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#29532 · TROMETHAMINE

Ingredients with overlapping formulation functions

TRISODIUM PHOSPHATEBUFFERING, CHELATING

TRISODIUM SULFOSUCCINATEBUFFERING, CHELATING, SURFACTANT - CLEANSING, SURFACTANT - HYDROTROPE

TRITICUM VULGARE PROTEINBUFFERING, FILM FORMING, HAIR CONDITIONING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN …

TRITICUM VULGARE SEED EXTRACTBUFFERING, DETANGLING, SKIN CONDITIONING, SKIN PROTECTING

UREAANTISTATIC, BUFFERING, HUMECTANT, SKIN CONDITIONING

URIC ACIDBUFFERING, SKIN CONDITIONING

ZINC CARBONATE HYDROXIDEBUFFERING, BULKING

ZINC GLYCINATEBUFFERING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TROMETHAMINE appears in the CosIng inventory

The CosIng inventory lists TROMETHAMINE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TROMETHAMINE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TROMETHAMINE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for TROMETHAMINE reads: "III/61". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, TROMETHAMINE carries the following function designation(s):

CAS 77-86-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TROMETHAMINE

This page combines the CosIng inventory entry for TROMETHAMINE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research TROMETHAMINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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