Official EU label nameGlossary entry 29532

TROMETHAMINE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

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Markets with evidence

Evidence gaps

Resolved identifiers

Resolved substance identity

CAS:77-86-1

EC:201-064-4

Ingredient index records:

TROMETHAMINE

Cosmetic functions: BUFFERING, FRAGRANCE

1,3-Propanediol, 2-amino-2-(hydroxymethyl)-

Inventory restriction note: III/61

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2 matched or reported names

TROMETHAMINEtrometamol

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name TROMETHAMINE.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 77-86-1

CAS 77-86-1PubChem CID 6503

Tris(hydroxymethyl)aminomethane

Tris is a primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 79; pKa = 8.3 at 20 C; pKa = 7.82 at 37 C. It has a role as a buffer. It is a triol and a primary amino compound. It is a conjugate base of a member of Htris. — ChEBI

IUPAC name: 2-amino-2-(hydroxymethyl)propane-1,3-diol

Molecular formula: C4H11NO3
Molecular weight: 121.14 g/mol
Exact mass: 121.07389321 Da
XLogP3: -2.9
Topological polar surface area: 86.7 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

TrometamolTROMETHAMINEThamTrisamine2-Amino-2-(hydroxymethyl)-1,3-propanediolTris bufferTromethaneTris-base

16 more reported names

TrisaminolPehanormTalatrolTutofusin trisTris-sterilAddex-tham1,3-Propanediol, 2-amino-2-(hydroxymethyl)-TrispufferTrimethylolaminomethaneTris AminoTris, free baseAminotrimethylolmethaneAminotris(hydroxymethyl)methaneTris(hydroxymethyl)methylamineTHAM-ETris (buffering agent)

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External database identifiers

ChEBI:CHEBI:9754
ChEMBL:CHEMBL1200391
EPA DTXSID:DTXSID2023723
PubMed:23107141
PubMed:23054718
PubMed:23037841
PubMed:23032750
PubMed:23016141
PubMed:23016110
PubMed:23011048
PubMed:23010469
PubMed:22990964
PubMed:22989297
PubMed:22975122
PubMed:22945490

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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