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CAS 77-86-1

CAS 77-86-1 matches 0 EU annex records across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 77-86-1
CAS 77-86-1PubChem CID 6503

Tris(hydroxymethyl)aminomethane

Tris is a primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 79; pKa = 8.3 at 20 C; pKa = 7.82 at 37 C. It has a role as a buffer. It is a triol and a primary amino compound. It is a conjugate base of a member of Htris. — ChEBI

IUPAC name
2-amino-2-(hydroxymethyl)propane-1,3-diol
Molecular formula
C4H11NO3
Molecular weight
121.14 g/mol
Exact mass
121.07389321 Da
XLogP3
-2.9
Topological polar surface area
86.7 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

TrometamolTROMETHAMINEThamTrisamine2-Amino-2-(hydroxymethyl)-1,3-propanediolTris bufferTromethaneTris-base
16 more reported names
TrisaminolPehanormTalatrolTutofusin trisTris-sterilAddex-tham1,3-Propanediol, 2-amino-2-(hydroxymethyl)-TrispufferTrimethylolaminomethaneTris AminoTris, free baseAminotrimethylolmethaneAminotris(hydroxymethyl)methaneTris(hydroxymethyl)methylamineTHAM-ETris (buffering agent)
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 77-86-1

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How CAS 77-86-1 is used on this site

CAS 77-86-1 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 0 EU annex records share this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 77-86-1 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.