What other records share CAS 109-29-5?

CAS 109-29-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 5636715/10/2010

HEXADECANOLACTONE

Oxacycloheptadecan-2-one; Hexadecanolide; dihydroambrettolide; juniperolactone

HEXADECANOLACTONE is linked to 1 EU annex record on this page.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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Market	Evidence status	Records	Source language
European Union	Evidence linked Restricted entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Evidence linked Restricted Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 109-29-5

CAS 109-29-5PubChem CID 7984

Hexadecanolide

16-Hexadecanolide is a macrolide. — ChEBI

IUPAC name: oxacycloheptadecan-2-one

Molecular formula: C16H30O2
Molecular weight: 254.41 g/mol
Exact mass: 254.224580195 Da
XLogP3: 6.3
Topological polar surface area: 26.3 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

CyclohexadecanolidehexadecanolactoneJuniperic acid lactone16-Hexadecanolactone1,16-HexadecanolideNSC-3354664E2HO00C7RefChem:786039

16 more reported names

203-662-016-HexadecanolideDihydroambrettolide1-oxacycloheptadecan-2-one1,16-Hexadecanolactone16-Hydroxyhexadecanoic acid lactoneNSC 33546JUNIPERIC ACID, LACTONE5-17-09-00108 (Beilstein Handbook Reference)AS-81214HEXADECANOIC ACID, 16-HYDROXY-, O-LACTONE1,16-Hexadecalactonehexadecano-16-lactoneEINECS 203-662-0BRN 0148631juniper muscone

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:179821
ChEMBL:CHEMBL3189021
EPA DTXSID:DTXSID4047622
PubMed:24248574
PubMed:21802479
PubMed:18975906
PubMed:17914582
PubMed:17191826
PubMed:11807759
PubMed:11735540
PubMed:11408205

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match7984

Attributed physical-property, hazard, environmental and use annotations.

Physical Description: Liquid Source: EPA Chemical Data Reporting (CDR)

Note: This chemical does not meet GHS hazard criteria for 86.3% (271 of 314) of all reports. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H315 (13.7%): Causes skin irritation [Warning Skin corrosion/irritation] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P264, P280, P302+P352, P321, P332+P317, and P362+P364 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 314 reports by companies from 4 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 271 of 314 reports by companies.; There are 3 notifications provided by 43 of 314 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Consumer Uses: Fragrance Source: EPA Chemical Data Reporting (CDR)

Industry Uses: Fragrance Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for HEXADECANOLACTONE

INCI name

HEXADECANOLACTONE

Description

Oxacycloheptadecan-2-one; Hexadecanolide; dihydroambrettolide; juniperolactone

Record provenance

Inventory reference: 56367
Imported identity: HEXADECANOLACTONE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for HEXADECANOLACTONE

Annex III Identified ingredient

Entry 335

Hexadecanolactone

CAS: 109-29-5

EC: 203-662-0

Key data

CAS

109-29-5

203-662-0

Restriction

—

Function

FRAGRANCE: Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
PERFUMING: Used for perfume and aromatic raw materials.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#11842 · HEXADECANOLACTONE

Ingredients with overlapping formulation functions

HELICHRYSUM ITALICUM FLOWER/LEAF/STEM OILFLAVOURING, FRAGRANCE, SKIN CONDITIONING

HELIOTROPINEFRAGRANCE, PERFUMING, SKIN CONDITIONING

HEPTAMETHYL DECAHYDROINDENOFURANFRAGRANCE

HETEROTHECA INULOIDES FLOWER EXTRACTFRAGRANCE

HEXAMETHYLINDANOPYRANFRAGRANCE, PERFUMING

HEXANALFRAGRANCE

HEXENYL ACETATEFLAVOURING, FRAGRANCE, PERFUMING

HEXYL ACETATEFLAVOURING, FRAGRANCE, PERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How HEXADECANOLACTONE appears in the CosIng inventory

The CosIng inventory lists HEXADECANOLACTONE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HEXADECANOLACTONE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HEXADECANOLACTONE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

According to the EU CosIng inventory, HEXADECANOLACTONE carries the following function designation(s):

CAS 109-29-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for HEXADECANOLACTONE

This page combines the CosIng inventory entry for HEXADECANOLACTONE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research HEXADECANOLACTONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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