Hexadecanolactone
Oxacyclohepta- decan-2-one
Hexadecanolactone is listed in Annex III and may only be used under the conditions shown in this record.
Chemical identity and properties
- IUPAC name
- oxacycloheptadecan-2-one
- Molecular formula
- C16H30O2
- Molecular weight
- 254.41 g/mol
- Exact mass
- 254.224580195 Da
- XLogP3
- 6.3
- Topological polar surface area
- 26.3 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:179821
- ChEMBL:CHEMBL3189021
- EPA DTXSID:DTXSID4047622
- PubMed:24248574
- PubMed:21802479
- PubMed:18975906
- PubMed:17914582
- PubMed:17191826
- PubMed:11807759
- PubMed:11735540
- PubMed:11408205
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Physical Description: Liquid Source: EPA Chemical Data Reporting (CDR)
- Note: This chemical does not meet GHS hazard criteria for 86.3% (271 of 314) of all reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H315 (13.7%): Causes skin irritation [Warning Skin corrosion/irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P264, P280, P302+P352, P321, P332+P317, and P362+P364 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 314 reports by companies from 4 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 271 of 314 reports by companies.; There are 3 notifications provided by 43 of 314 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Consumer Uses: Fragrance Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Fragrance Source: EPA Chemical Data Reporting (CDR)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Other restrictions
The presence of the substance shall be indicated in the list of ingredients referred to in Article 19(1), point (g), when its concentration exceeds: — 0,001 % in leave-on products — 0,01 % in rinse-off products.
INCI glossary name
Hexadecanolactone
Chemical name
Oxacyclohepta- decan-2-one
Regulatory information
Identified ingredients
Key data
Inventory links for Hexadecanolactone
Related records for Hexadecanolactone
Direct matches are limited for this record, so nearby entries from Annex III are shown as well.
Carvone
Menthol
Camphor
Trimethylcyclopentenyl Methylisopentenol
Anethole
Santalol
What Annex III means for Hexadecanolactone
Hexadecanolactone is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.
When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.
This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Document conditions of use in the Product Information File (PIF).
Frequently asked questions
Source note for Annex III record Hexadecanolactone
This page summarizes one Annex III record for Hexadecanolactone from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex III conditions for Hexadecanolactone, but confirm any final regulatory decision against the current official annex wording and source files.
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