Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
InventoryRef 3424515/10/2010

HELIOTROPINE

1,3-Benzodioxole-5-carboxaldehyde

HELIOTROPINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

INCI CheckerCompare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sourcesSearch every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 120-57-0
CAS 120-57-0PubChem CID 8438

Piperonal

Piperonal is an arenecarbaldehyde that is 1,3-benzodioxole substituted by a formyl substituent at position 5. It has been isolated from Piper nigrum. It has a role as a fragrance, an insect repellent and a plant metabolite. It is an arenecarbaldehyde and a member of benzodioxoles. — ChEBI

IUPAC name
1,3-benzodioxole-5-carbaldehyde
Molecular formula
C8H6O3
Molecular weight
150.13 g/mol
Exact mass
150.031694049 Da
XLogP3
1.1
Topological polar surface area
35.5 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

HeliotropinHeliotropinePiperonyl aldehydePiperonaldehydePiperonylaldehydeGeliotropin3,4-Methylenedioxybenzaldehyde1,3-Benzodioxole-5-carboxaldehyde
16 more reported names
3,4-(Methylenedioxy)benzaldehyde5-Formyl-1,3-benzodioxoleProtocatechuic aldehyde methylene ether3,4-Dihydroxybenzaldehyde methylene ketal3,4-DimethylenedioxybenzaldehydeFEMA No. 29112H-1,3-Benzodioxole-5-CarbaldehydeDioxymethylene protocatechuic aldehydeBenzaldehyde, 3,4-(methylenedioxy)-KE109YAK00NSC-26826CHEBI:8240DIOXYMETHYLENEPROTOCATECHUIC ALDEHYDEheliotrinRefChem:46197204-409-7
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8438

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 15.9% (329 of 2063) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H317 (81.6%): May cause an allergic skin reaction [Warning Sensitization, Skin] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2063 reports by companies from 14 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 329 of 2063 reports by companies.; There are 12 notifications provided by 1734 of 2063 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H330: Fatal if inhaled [Danger Acute toxicity, inhalation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P271, P280, P284, P301+P316, P302+P352, P304+P340, P308+P316, P316, P317, P318, P319, P320, P321, P330, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
  • GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Substances Data Bank (HSDB)
  • Precautionary Statement Codes: P264, P273, P280, P302+P352, P321, P332+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Piperonal is a solid. It is used in perfumery, flavors, and organic syntheses. A constituent of vanilla and cherry flavors. It has also been used for the treatment of head lice. HUMAN STUDIES: Ten grams of piperonal were ingested by man without any adverse effect. ANIMAL STUDIES: When rats were given 13-115 mg piperonal perorally for 5-9 days, fatty infiltration of the liver parenchymal cells was noted. Intragastric administration of 900 mg/kg bw per day to 3 male and 3 female rats for 4 days produced slight gross liver damage in some animals. Groups of 20 male and 20 female rats were fed on diets containing 0, 0.1 and 0.5 % piperonal for 2 years without any specific adverse effect. Based of a feeding study in rats at 500 mg/kg bw per day for a period of 15 weeks NOAEL of 500 mg/kg bw was determined. Piperonal was positive in the Bacillus subtilis DNA-repair test (Rec assay) without metabolic activation, but it was negative when tested in the Ames Salmonella reversion assay or in the Escherichia coli WP2 uvrA reversion test. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 2.3 was calculated in fish for piperonal(SRC), using a log Kow of 1.05(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 24(SRC), determined from a log Kow of 1.05(2) and a regression-derived equation(3), indicates that piperonal is expected to have very high mobility in soil(SRC). Volatilization of piperonal from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.6X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 0.01 mm Hg(4), and water solubility, 3,500 mg/L(5). Piperonal has a vapor pressure of 0.01 mm Hg(4) and exudes a floral odor under environmental conditions: therefore, piperonal may volatilize from dry soil(SRC). Utilizing the Japanese MITI test, 88% of the Theoretical BOD was reached in 2 weeks(6) indicating that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 24(SRC), determined from a log Kow of 1.05(2) and a regression-derived equation(3), indicates that piperonal is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 5.6X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 0.01 mm Hg(5), and water solubility, 3,500 mg/L(6). According to a classification scheme(7), an estimated BCF of 2.3(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 88% of the Theoretical BOD was reached in 2 weeks(8) indicating that biodegradation is an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), piperonal, which has a vapor pressure of 0.01 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase piperonal is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 14 hrs(SRC), calculated from its rate constant of 2.9X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Piperonal contains chromophores that absorb at wavelengths >290 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for HELIOTROPINE

INCI name

HELIOTROPINE

Description

1,3-Benzodioxole-5-carboxaldehyde

Record provenance

Inventory reference
34245
Imported identity
HELIOTROPINE
Source update
15/10/2010
European Commission CosIng source notes
Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search

Search annex entries

Search the annex database for entries matching HELIOTROPINE or related substances.

Key data

CAS
120-57-0
EC
204-409-7
Restriction
—
Function
FRAGRANCE
Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
PERFUMING
Used for perfume and aromatic raw materials.
SKIN CONDITIONING
Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#11715 · HELIOTROPINE

Ingredients with overlapping formulation functions

HELICHRYSUM ANGUSTIFOLIUM FLOWER OILFRAGRANCE, PERFUMING
HELICHRYSUM ITALICUM EXTRACTANTI-SEBUM, FRAGRANCE, SOOTHING
HELICHRYSUM ITALICUM FLOWER OILFRAGRANCE, PERFUMING
HELICHRYSUM ITALICUM FLOWER/LEAF/STEM OILFLAVOURING, FRAGRANCE, SKIN CONDITIONING
HEPTAMETHYL DECAHYDROINDENOFURANFRAGRANCE
HETEROTHECA INULOIDES FLOWER EXTRACTFRAGRANCE
HEXADECANOLACTONEFRAGRANCE, PERFUMING
HEXAMETHYLINDANOPYRANFRAGRANCE, PERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How HELIOTROPINE appears in the CosIng inventory

The CosIng inventory lists HELIOTROPINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HELIOTROPINE is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HELIOTROPINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, HELIOTROPINE carries the following function designation(s):

CAS 120-57-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Open INCI Checker

Source note for HELIOTROPINE

This page reproduces the CosIng inventory entry for HELIOTROPINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research HELIOTROPINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sourcesView updates

Tools & next steps

Check your formula

Scan a full INCI list to detect HELIOTROPINE and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to HELIOTROPINE, its identifiers or nearby name variants.

Search