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InventoryRef 5435907/08/2020

ALPHA-ARBUTIN

4-Hydroxyphenyl-alpha-D-glucopyranoside

ALPHA-ARBUTIN is linked to 1 EU annex record on this page.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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MarketEvidence statusRecordsSource language
European UnionEvidence linked
Restricted entry found
Open this evidence		1English and EU languages
Great BritainSource mapped
Official source mapped; ingredient rule not imported
0English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandSource mapped
Official source mapped; ingredient rule not imported
0English
ASEANSource mapped
Official source mapped; ingredient rule not imported
0English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaEvidence linked
Restricted
Open this evidence		1Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 84380-01-8
CAS 84380-01-8PubChem CID 158637

Alpha-Arbutin

Alpha-Arbutin is a glycoside. — ChEBI

IUPAC name
(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol
Molecular formula
C12H16O7
Molecular weight
272.25 g/mol
Exact mass
272.08960285 Da
XLogP3
-0.7
Topological polar surface area
120.0 Ų
Hydrogen-bond donors
5
Hydrogen-bond acceptors
7
Covalent units
1
Defined stereocentres
5

Also known as

alpha arbutinUNII-72VUP07IT572VUP07IT5ORISTAR AATP-HYDROXYPHENYL-alpha-D-GLUCOPYRANOSIDERefChem:58967Derma Pella Intimate Brightening4-Hydroxyphenyl a-D-glucopyranoside
16 more reported names
a-Arbutin4-hydroxyphenyl alpha-D-glucopyranosideAC1L4KBIa-D-Glucopyranoside, 4-hydroxyphenylalpha-D-Glucopyranoside, 4-hydroxyphenylf inverted question mark-Arbutin(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydropyran-3,4,5-triolP-HYDROXYPHENYL-.ALPHA.-D-GLUCOPYRANOSIDE4-Hydroquinone-alpha-d-glucopyranosideAlpha ArbutineAlfa Arbutinaalpha-Arbutosides5112| cent-ArbutinI+/--Arbutin
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ALPHA-ARBUTIN

INCI name

ALPHA-ARBUTIN

Description

4-Hydroxyphenyl-alpha-D-glucopyranoside

Record provenance

Inventory reference
54359
Imported identity
ALPHA-ARBUTIN
Source update
07/08/2020
European Commission CosIng source notes
Annex III Identified ingredient
Entry 377

Alpha-Arbutin

CAS: 84380-01-8
EC: 617-561-8

Key data

CAS
84380-01-8
EC
283-934-3
Restriction
—
Function
ANTIOXIDANT
Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
BLEACHING
Bleaching or lightening the shade of hair and/or skin.
SKIN CONDITIONING - MISCELLANEOUS
Enhancing the appearance of dry and/or damaged skin by reducing flaking and restoring suppleness.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#1467 · ALPHA-ARBUTIN

Records sharing a CAS or EC identity

ARCTOSTAPHYLOS UVA URSI LEAF EXTRACTARCTOSTAPHYLOS UVA URSI LEAF POWDER

Ingredients with overlapping formulation functions

AJUGA REPTANS CELL CULTURE EXTRACTANTIOXIDANT, BLEACHING, CHELATING
ALLAMANDA CATHARTICA FLOWER EXTRACTBLEACHING
ALLIUM MINUS EXTRACTANTIMICROBIAL; BLEACHING; SKIN PROTECTING; SKIN CONDITIONING - MISCELLANEOUS
ALLOFERON-1BLEACHING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING
ALPINIA OXYPHYLLA FRUIT EXTRACTANTIOXIDANT; BLEACHING
AMENTOFLAVONEANTIOXIDANT, BLEACHING
AMINOLEVULINOYL TRIPEPTIDE-35BLEACHING, HAIR CONDITIONING, SKIN PROTECTING
AMMONIUM PERSULFATEBLEACHING, OXIDISING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How ALPHA-ARBUTIN appears in the CosIng inventory

The CosIng inventory lists ALPHA-ARBUTIN as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ALPHA-ARBUTIN is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ALPHA-ARBUTIN appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

According to the EU CosIng inventory, ALPHA-ARBUTIN carries the following function designation(s):

CAS 84380-01-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for ALPHA-ARBUTIN

This page combines the CosIng inventory entry for ALPHA-ARBUTIN with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research ALPHA-ARBUTIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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