Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
CAS 1 record

CAS 84380-01-8

CAS 84380-01-8 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

Check this CAS numberBrowse annexes

Chemical identity and properties

PubChem 2D chemical structure for CAS 84380-01-8
CAS 84380-01-8PubChem CID 158637

Alpha-Arbutin

Alpha-Arbutin is a glycoside. — ChEBI

IUPAC name
(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol
Molecular formula
C12H16O7
Molecular weight
272.25 g/mol
Exact mass
272.08960285 Da
XLogP3
-0.7
Topological polar surface area
120.0 Ų
Hydrogen-bond donors
5
Hydrogen-bond acceptors
7
Covalent units
1
Defined stereocentres
5

Also known as

alpha arbutinUNII-72VUP07IT572VUP07IT5ORISTAR AATP-HYDROXYPHENYL-alpha-D-GLUCOPYRANOSIDERefChem:58967Derma Pella Intimate Brightening4-Hydroxyphenyl a-D-glucopyranoside
16 more reported names
a-Arbutin4-hydroxyphenyl alpha-D-glucopyranosideAC1L4KBIa-D-Glucopyranoside, 4-hydroxyphenylalpha-D-Glucopyranoside, 4-hydroxyphenylf inverted question mark-Arbutin(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydropyran-3,4,5-triolP-HYDROXYPHENYL-.ALPHA.-D-GLUCOPYRANOSIDE4-Hydroquinone-alpha-d-glucopyranosideAlpha ArbutineAlfa Arbutinaalpha-Arbutosides5112| cent-ArbutinI+/--Arbutin
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 84380-01-8

1 total
Annex
III
Entry
377

Alpha-Arbutin

4-Hydroxyphenyl-alpha-D-glucopyranoside

Hydroquinone levels shall remain as low as possible in formulations containing alpha-Arbutin and shall not be higher than the unavoidable trace level. From 1 February 2025 cosmetic products containing that substance an…

EC
617-561-8
Max concentration

How CAS 84380-01-8 is used on this site

CAS 84380-01-8 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 84380-01-8 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 84380-01-8 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.
Check this CAS number

Tools & next steps

Check your formula

Scan a full INCI list, then use CAS 84380-01-8 to cross-check any supplier documents behind the matched substances.

INCI Checker

Browse annexes

Browse all EU cosmetic regulation annexes by category.

All annexes

Search by name

Search for INCI names, aliases or related identifiers that sit alongside CAS 84380-01-8 in your documentation.

Search