Is AMENTOFLAVONE safe to use in EU cosmetics?

AMENTOFLAVONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 1617-53-4?

CAS 1617-53-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8826230/11/2011

AMENTOFLAVONE

Bis-Apigenin ; 4H-1-Benzopyran-4-one, 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2- yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)- .

AMENTOFLAVONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 1617-53-4

CAS 1617-53-4PubChem CID 5281600

Amentoflavone

Amentoflavone is a biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-8 of the chromene ring. A natural product found particularly in Ginkgo biloba and Hypericum perforatum. It has a role as an antiviral agent, an angiogenesis inhibitor, a P450 inhibitor, a cathepsin B inhibitor and a plant metabolite. It is a hydroxyflavone, a ring assembly and a biflavonoid. — ChEBI

IUPAC name: 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one

Molecular formula: C30H18O10
Molecular weight: 538.5 g/mol
Exact mass: 538.08999677 Da
XLogP3: 5.0
Topological polar surface area: 174.0 Å²
Hydrogen-bond donors: 6
Hydrogen-bond acceptors: 10
Covalent units: 1
Defined stereocentres: 0

Also known as

Didemethyl-ginkgetin3',8''-BiapigeninTridemethylsciadopitysin9I1VC79L77NSC-295677CHEBI:26314H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-Benzopyran-4-one, 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-

16 more reported names

8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one8-(5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-oneRefChem:111894Amenthoflavone8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one8-[5-(5,7-dihydroxy-4-oxo-chromen-2-yl)-2-hydroxy-phenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-oneI3',II8-BIAPIGENINBIDD:PXR0028GINKGETIN, DIDEMETHYL-med.21724, Compound 138CCG-2699508-[5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-oneSR-01000721725-2SR-01000721725UNII-9I1VC79L77

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:2631
ChEMBL:CHEMBL63354
EPA DTXSID:DTXSID20167225
PubMed:41524907
PubMed:40915523
PubMed:38225072
PubMed:34599948
PubMed:32421801
PubMed:29470958
PubMed:28185818
PubMed:26456343
PubMed:22445328
PubMed:19775597
PubMed:17473463
PubMed:17003167

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for AMENTOFLAVONE

INCI name

AMENTOFLAVONE

Description

Bis-Apigenin ;
4H-1-Benzopyran-4-one, 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2- yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)- .

Record provenance

Inventory reference: 88262
Imported identity: AMENTOFLAVONE
Source update: 30/11/2011

European Commission CosIng source notes

Annex records for AMENTOFLAVONE

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Key data

CAS

1617-53-4

—

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
BLEACHING: Bleaching or lightening the shade of hair and/or skin.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#1672 · AMENTOFLAVONE

Ingredients with overlapping formulation functions

ALLIUM MINUS EXTRACTANTIMICROBIAL; BLEACHING; SKIN PROTECTING; SKIN CONDITIONING - MISCELLANEOUS

ALLOFERON-1BLEACHING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

ALPHA-ARBUTINANTIOXIDANT, BLEACHING, SKIN CONDITIONING - MISCELLANEOUS

ALPINIA OXYPHYLLA FRUIT EXTRACTANTIOXIDANT; BLEACHING

AMINOLEVULINOYL TRIPEPTIDE-35BLEACHING, HAIR CONDITIONING, SKIN PROTECTING

AMMONIUM PERSULFATEBLEACHING, OXIDISING

ANACARDOYL SH-PENTAPEPTIDE-39 TRIPEPTIDE-1ANTIOXIDANT, BLEACHING, SKIN PROTECTING

ANACARDOYL SH-PENTAPEPTIDE-5 TRIPEPTIDE-1ANTIOXIDANT, BLEACHING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How AMENTOFLAVONE appears in the CosIng inventory

The CosIng inventory lists AMENTOFLAVONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

AMENTOFLAVONE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

AMENTOFLAVONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, AMENTOFLAVONE carries the following function designation(s):

CAS 1617-53-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for AMENTOFLAVONE

This page reproduces the CosIng inventory entry for AMENTOFLAVONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research AMENTOFLAVONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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