InventoryRef 5420815/10/2010
4-AMINO-2-NITROPHENOL
4-Amino-2-nitrophenol
4-AMINO-2-NITROPHENOL is linked to 1 EU annex record on this page. Inventory note: II/412.
Regulatory evidence by market
This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.
Swipe or scroll horizontally to see every column.
| Market | Evidence status | Records | Source language |
|---|---|---|---|
| European Union | Evidence linked Prohibited entry found Open this evidence | 1 | English and EU languages |
| Great Britain | Evidence linked Prohibited Open this evidence | 1 | English |
| Canada | Evidence linked Prohibited Open this evidence | 1 | English and French |
| New Zealand | Evidence linked Prohibited Open this evidence | 1 | English |
| ASEAN | Evidence linked Prohibited Open this evidence | 1 | English and national languages |
| China | Evidence linked Prohibited Open this evidence | 1 | Chinese with selected English material |
| Japan | Source mapped Official source mapped; ingredient rule not imported | 0 | Japanese; official English translation available |
| South Korea | Evidence linked Prohibited Open this evidence | 1 | Korean with some English names |
| United States | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Australia | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Brazil | Evidence linked Prohibited Open this evidence | 1 | Portuguese with INCI crosswalks |
| India | Evidence linked Prohibited Open this evidence | 1 | English and Hindi |
| Saudi Arabia | Evidence linked Prohibited Open this evidence | 1 | Arabic and English |
Chemical identity and properties
CAS 119-34-6PubChem CID 3417419
4-Amino-2-Nitrophenol
4-Amino-2-nitrophenol is a member of 2-nitrophenols. — ChEBI
- IUPAC name
- 4-amino-2-nitrophenol
- Molecular formula
- C6H6N2O3
- Molecular weight
- 154.12 g/mol
- Exact mass
- 154.03784206 Da
- XLogP3
- 1.0
- Topological polar surface area
- 92.1 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
4-Hydroxy-3-nitroanilinePhenol, 4-amino-2-nitro-Fourrine 57Fourrine Brown PR2-Nitro-4-aminophenolOxidation Base 253-Nitro-4-hydroxyanilineFourrine Brown Propyl
16 more reported names
o-Nitro-p-aminophenolp-Amino-o-nitrophenolC.I. Oxidation Base 251-Amino-3-nitro-4-hydroxybenzeneNCI-C03963CI Oxidation Base 25C.I. 76555ortho-Nitro-para-aminophenolCI 76555N3499RCQ6BNSC-56809DTXCID4064CI-76555RefChem:97704204-316-14-Amino-2-nitrofenol
External database identifiers
- ChEBI:CHEBI:82385
- ChEMBL:CHEMBL1516868
- EPA DTXSID:DTXSID6020064
- PubMed:21962688
- PubMed:20086194
- PubMed:17389084
- PubMed:12498276
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match3417419
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 110 °C at 12 mm Hg Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Dark-red plates or needles from water and ethanol Source: Hazardous Substances Data Bank (HSDB)
- Dissociation Constants: pKa = 7.81 at 25 °C (phenol) Source: Hazardous Substances Data Bank (HSDB)
- LogP: log Kow = 0.96 Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 261 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: 131 °C Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: 4-amino-2-nitrophenol appears as dark red plates, needles or reddish-purple powder. Melting point 125-127 °C. Source: CAMEO Chemicals
- Physical Description: Dark red solid; [HSDB] Red-brown crystalline powder; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: less than 0.1 mg/mL at 70 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: Soluble in water, ethanol, diethyl ether; slightly soluble in dimethylsulfoxide Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: 0.0000352 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- IARC Carcinogenic Agent: 4-Amino-2-nitrophenol Source: International Agency for Research on Cancer (IARC)
- IARC Carcinogenic Classes: Group 3: Not classifiable as to its carcinogenicity to humans Source: International Agency for Research on Cancer (IARC)
- IARC Monographs: Volume 16: (1978) Some Aromatic Amines and Related Nitro Compounds – Hair Dyes, Colouring Agents and Miscellaneous Industrial Chemicals; Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) Source: International Agency for Research on Cancer (IARC)
- Publication Year: 1987 Source: International Agency for Research on Cancer (IARC)
- Evaluation Year: 1987 Source: International Agency for Research on Cancer (IARC)
- Substance: 4-Amino-2-nitrophenol Source: NTP Technical Reports
- NTP Technical Report: TR-094: Bioassay of 4-Amino-2-nitrophenol for Possible Carcinogenicity (CASRN 119-34-6) (1978 ) Source: NTP Technical Reports
- Peer Review Date: 04/26/78 Source: NTP Technical Reports
- Conclusion for Male Rat: Clear Evidence Source: NTP Technical Reports
- Conclusion for Female Rat: Equivocal Evidence Source: NTP Technical Reports
- Conclusion for Male Mice: No Evidence Source: NTP Technical Reports
- Conclusion for Female Mice: No Evidence Source: NTP Technical Reports
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (12.8%): Causes skin irritation [Warning Skin corrosion/irritation]; H318 (12.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H335 (10.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H341 (10.6%): Suspected of causing genetic defects [Warning Germ cell mutagenicity] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P318, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 47 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Cosmetic Ingredient Review Conclusion: Based on the data contained in this report, the CIR Expert Panel concludes that 2-amino-3-nitrophenol, 2-amino-4-nitrophenol,2-amino-4-nitrophenol sulfate, 2-amino-5-nitrophenol, 4-amino-3-nitrophenol, 3-nitro-p-hydroxyethylaminophenol, and 4-hydroxypropylamino-3-nitrophenol are safe as hair dye ingredients in the practices of use and concentration as described in this safety assessment, but the data are insufficient to make a determination of safety for 4-amino-2-nitrophenol. Source: Cosmetic Ingredient Review (CIR)
- Cosmetic Ingredient Review Finding(s): Ingredients for which the data are insufficient and their use in cosmetics is not supported Source: Cosmetic Ingredient Review (CIR)
- Environmental Bioconcentration: An estimated BCF of 3 was calculated for 4-amino-2-nitrophenol(SRC), using a log Kow of 0.96(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 79(SRC), determined from a log Kow of 0.96(2) and a regression-derived equation(3), indicates that 4-amino-2-nitrophenol is expected to have high mobility in soil(SRC). Volatilization of 4-amino-2-nitrophenol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.2X10-12 atm-cu m/mole(SRC), using a fragment constant estimation method(4)). 4-Amino-2-nitrophenol is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.5X10-5 mm Hg(SRC), determined from a fragment constant method(5). Incomplete data were available regarding the biodegradation potential of 4-amino-2-nitrophenol(SRC, 2008); however, Nocardia v. was able to use this compound as a carbon source for limited growth under aerobic conditions(6). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 79(SRC), determined from a log Kow of 0.96(2) and a regression-derived equation(3), indicates that 4-amino-2-nitrophenol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.3X10-12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(6), suggests bioconcentration in aquatic organisms is low(SRC). Incomplete data were available regarding the biodegradation potential of 4-amino-2-nitrophenol(SRC, 2008); however, Nocardia v. was able to use this compound as a carbon source for limited growth under aerobic conditions(7). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 4-amino-2-nitrophenol, which has an estimated vapor pressure of 3.5X10-5 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 4-amino-2-nitrophenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2.3 days(SRC), calculated from its rate constant of 7.0X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3) Particulate-phase 4-amino-2-nitrophenol may be removed from the air by wet or dry deposition(SRC). 4-Amino-2-nitrophenol contains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Cosmetic Ingredient Review Link: CIR ingredient: 4-Amino-2-Nitrophenol Source: Cosmetic Ingredient Review (CIR)
- Sources/Uses: Used to dye furs, to dye hair, and to etch copper printing plates; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Fur Dressing and Dyeing [Category: Industry]; Dressing Hair [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: 4-Amino-2-nitrophenol is used in dyeing furs a beige or deep reddish brown. It is also used in hair dyes. /SRP: FORMER/ Source: Hazardous Substances Data Bank (HSDB)
- Uses: 4-Amino-2-nitrophenol is used in the etching of copper printing plates. Source: Hazardous Substances Data Bank (HSDB)
- Uses: ... Used in hair dyes ... used in textile dye synthesis. /SRP: FORMER/ Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for 4-AMINO-2-NITROPHENOL
INCI name
4-AMINO-2-NITROPHENOL
Description
4-Amino-2-nitrophenol
Record provenance
- Inventory reference
- 54208
- Imported identity
- 4-AMINO-2-NITROPHENOL
- Source update
- 15/10/2010
Annex records for 4-AMINO-2-NITROPHENOL
Key data
CAS
EC
—
Restriction
II/412
Function
- HAIR DYEING
- Imparting color to hair. Hair dyeing preparations may be temporary, semi-permanent, or permanent, depending on the length of time the colorant remains on the hair.
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal
How 4-AMINO-2-NITROPHENOL appears in the CosIng inventory
The CosIng inventory lists 4-AMINO-2-NITROPHENOL as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.
4-AMINO-2-NITROPHENOL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
4-AMINO-2-NITROPHENOL appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.
The restriction field for 4-AMINO-2-NITROPHENOL reads: "II/412". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.
According to the EU CosIng inventory, 4-AMINO-2-NITROPHENOL carries the following function designation(s):
CAS 119-34-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Source note for 4-AMINO-2-NITROPHENOL
This page combines the CosIng inventory entry for 4-AMINO-2-NITROPHENOL with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.
Use this inventory page to research 4-AMINO-2-NITROPHENOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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