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CAS 500-38-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 3555915/10/2010

NORDIHYDROGUAIARETIC ACID

4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol

NORDIHYDROGUAIARETIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 500-38-9

CAS 500-38-9PubChem CID 4534

Nordihydroguaretic acid

Nordihydroguaiaretic acid is a tetrol that is butane which is substituted at positions 2 and 3 by 3,4-dihydroxybenzyl groups. Masoprocol, the meso-form found in the leaves of the creosote bush (Larrea divaricata), is a potent lipoxygenase inhibitor. It has a role as a ferroptosis inhibitor, a geroprotector, an antioxidant and a plant metabolite. It is a lignan, a member of catechols and a tetrol. — ChEBI

IUPAC name: 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol

Molecular formula: C18H22O4
Molecular weight: 302.4 g/mol
Exact mass: 302.15180918 Da
XLogP3: 4.3
Topological polar surface area: 80.9 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

2,3-bis(3,4-dihydroxybenzyl)butaneRefChem:854717NORDIHYDROGUAIARETIC ACIDNDGANorhydroguaiaretic acidNorguaiaretic acid, dihydro-1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-NSC 4291

16 more reported names

4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol2,3-Bis(3,4-dihydroxyphenylmethyl)butanePyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di-4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol)nordihydroguaiaretateCHEMBL52Butane, 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl-4,4'-(2,3-dimethylbutane-1,4-diyl)bis(benzene-1,2-diol)beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butaneCHX 100; Masoprocol; meso-NDGA4,4'-(2,3-Dimethyl-1,4-butanediyl)bis-1,2-benzenediol4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]benzene-1,2-diolNordihydroGuaiareticAcid-d6Nordihydro Guaiaretic Acid (mixture of diastereomers)4,4'-(2,3-dimethylbutane-1,4-diyl)dibenzene-1,2-diol4,4'-(2,3-Dimethylbutane-1,4-diyl)di(benzene-1,2-diol)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:7625
ChEMBL:CHEMBL52
EPA DTXSID:DTXSID5022437
PubMed:7875307

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for NORDIHYDROGUAIARETIC ACID

INCI name

NORDIHYDROGUAIARETIC ACID

Description

4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol

Record provenance

Inventory reference: 35559
Imported identity: NORDIHYDROGUAIARETIC ACID
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for NORDIHYDROGUAIARETIC ACID

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Key data

CAS

500-38-9

207-903-0

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17613 · NORDIHYDROGUAIARETIC ACID

Ingredients with overlapping formulation functions

NICTOFLORINANTIOXIDANT, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

NIFEDIPINEANTIOXIDANT

NOBILETINANTIMICROBIAL, ANTIOXIDANT, PRESERVATIVE

NONAPEPTIDE-10ANTIOXIDANT, CHELATING, SKIN PROTECTING

NOSTOC COMMUNE/HYDRANGEA SERRATA LEAF/SOYBEAN FERMENT FILTRATEANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING

NYMPHAEA GIGANTEA FLOWER EXTRACTANTIOXIDANT, FRAGRANCE, HAIR CONDITIONING, PERFUMING, SKIN PROTECTING

NYMPHAEA TETRAGONA CALLUS CULTURE EXTRACTANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

NYMPHOIDES HYDROPHYLLA STEM EXTRACTANTIOXIDANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How NORDIHYDROGUAIARETIC ACID appears in the CosIng inventory

The CosIng inventory lists NORDIHYDROGUAIARETIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NORDIHYDROGUAIARETIC ACID is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NORDIHYDROGUAIARETIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NORDIHYDROGUAIARETIC ACID carries the following function designation(s):

ANTIOXIDANT

CAS 500-38-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for NORDIHYDROGUAIARETIC ACID

This page reproduces the CosIng inventory entry for NORDIHYDROGUAIARETIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NORDIHYDROGUAIARETIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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