Is NIFEDIPINE safe to use in EU cosmetics?

NIFEDIPINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 21829-25-4?

CAS 21829-25-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains NIFEDIPINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9524720/02/2018

NIFEDIPINE

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3,5-dimethyl ester

NIFEDIPINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 21829-25-4

CAS 21829-25-4PubChem CID 4485

Nifedipine

Nifedipine is a methyl ester, a C-nitro compound and a dihydropyridine. It has a role as a vasodilator agent, a calcium channel blocker, a tocolytic agent and a human metabolite. — ChEBI

IUPAC name: dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Molecular formula: C17H18N2O6
Molecular weight: 346.3 g/mol
Exact mass: 346.11648630 Da
XLogP3: 2.2
Topological polar surface area: 110.0 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 7
Covalent units: 1
Defined stereocentres: 0

Also known as

ProcardiaAdalatProcardia XLCitilatOxcordAdalat CCFenihidineBay-a-1040

16 more reported names

CoractenAfeditab CRNifedipinoNifedipinumAdipine XLAfeditabCalcilatNifedicalBAY A 10401,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl esterNifensar XL3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl esterNifedical XLAdalate LPNifedipine slow release3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:7565
ChEMBL:CHEMBL193
EPA DTXSID:DTXSID2025715
PubMed:36207783
PubMed:34170685
PubMed:33814510
PubMed:32226695
PubMed:32209977
PubMed:31618660
PubMed:30965050
PubMed:30725737
PubMed:30503582
PubMed:29741611
PubMed:28899749
PubMed:28611661

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for NIFEDIPINE

INCI name

NIFEDIPINE

Description

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3,5-dimethyl ester

Record provenance

Inventory reference: 95247
Imported identity: NIFEDIPINE
Source update: 20/02/2018

European Commission CosIng source notes

Annex records for NIFEDIPINE

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Key data

CAS

21829-25-4

—

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17463 · NIFEDIPINE

Ingredients with overlapping formulation functions

NICOTINOYL PENTAPEPTIDE-33ANTIOXIDANT, SKIN PROTECTING

NICOTINOYL TRIPEPTIDE-1ANTIOXIDANT, CHELATING, SKIN PROTECTING

NICOTINOYL TRIPEPTIDE-35ANTIOXIDANT

NICTOFLORINANTIOXIDANT, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

NOBILETINANTIMICROBIAL, ANTIOXIDANT, PRESERVATIVE

NONAPEPTIDE-10ANTIOXIDANT, CHELATING, SKIN PROTECTING

NORDIHYDROGUAIARETIC ACIDANTIOXIDANT

NOSTOC COMMUNE/HYDRANGEA SERRATA LEAF/SOYBEAN FERMENT FILTRATEANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How NIFEDIPINE appears in the CosIng inventory

The CosIng inventory lists NIFEDIPINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NIFEDIPINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NIFEDIPINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NIFEDIPINE carries the following function designation(s):

ANTIOXIDANT

CAS 21829-25-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for NIFEDIPINE

This page reproduces the CosIng inventory entry for NIFEDIPINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NIFEDIPINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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