Is NICTOFLORIN safe to use in EU cosmetics?

NICTOFLORIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What function does NICTOFLORIN serve in cosmetics?

According to the EU CosIng inventory, NICTOFLORIN carries the following function designation(s): ANTIOXIDANT, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING.

What other records share CAS 17650-84-9?

CAS 17650-84-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains NICTOFLORIN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8393615/10/2010

NICTOFLORIN

Kaempferol-3-O-β-D-Rutinoside

NICTOFLORIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 17650-84-9

CAS 17650-84-9PubChem CID 5318767

Kaempferol-3-O-Rutinoside

Kaempferol-3-rutinoside is a kaempferol O-glucoside that is kaempferol attached to a rutinosyl [6-deoxy-alpha-L-mannosyl-(16)-beta-D-glucosyl] residue at position 3 via a glycosidic linkage. It has been isolated from the leaves of Solanum campaniforme. It has a role as a metabolite, a radical scavenger and a plant metabolite. It is a rutinoside, a trihydroxyflavone, a disaccharide derivative and a kaempferol O-glucoside. — ChEBI

IUPAC name: 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

Molecular formula: C27H30O15
Molecular weight: 594.5 g/mol
Exact mass: 594.15847025 Da
XLogP3: -0.9
Topological polar surface area: 245.0 Å²
Hydrogen-bond donors: 9
Hydrogen-bond acceptors: 15
Covalent units: 1
Defined stereocentres: 10

Also known as

NicotiflorinNictoflorinNICOTIFLOROSIDEKaempferol 3-RutinosideKaempferol-3-O-beta-rutinoside4056D20K3Hkaempferol 3-O-(6''-O-alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside4H-1-Benzopyran-4-one, 3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-

16 more reported names

RefChem:40126kaempferol-3-O-alpha-L-rhamanopyranosyl-(1'''-6'')-beta-D-glucopyranoside5,7-dihydroxy-2-(4-hydroxyphenyl)-3-((2S,5S)-3,4,5-trihydroxy-6-(((2R,4S,5R)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl)oxan-2-yl)oxychromen-4-oneKaempferol-3-rutinosideKaempferol 3-O-rutinosideKaempferol 3-O-beta-rutinosideKaempferol 3-O-|A -rutinosideFlavone, 3,4',5,7-tetrahydroxy-, 3-rhamnoglucosideKaempferol 3-O-b -Rutinoside (Nicotiflorin)Kaempferol-3-O-rutinosidNicotiflorineUNII-4056D20K3HKAEMPFEROL 3-RHAMNOGLUCOSIDEkampferol-3-rutinosideNicotiflorin (Standard)kaemferol-3-O-rutinoside

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:69657
ChEMBL:CHEMBL498879
EPA DTXSID:DTXSID50938804
PubMed:40819643
PubMed:39686653
PubMed:36223844
PubMed:34338262
PubMed:34041764
PubMed:33182332
PubMed:33157413
PubMed:28476711
PubMed:26901177
PubMed:23437066
PubMed:23417281

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for NICTOFLORIN

INCI name

NICTOFLORIN

Description

Kaempferol-3-O-β-D-Rutinoside

Record provenance

Inventory reference: 83936
Imported identity: NICTOFLORIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for NICTOFLORIN

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Key data

CAS

17650-84-9

—

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
SKIN CONDITIONING - EMOLLIENT: Acting as lubricants on the skin surface providing the skin with a soft and smooth appearance.
SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17462 · NICTOFLORIN

Ingredients with overlapping formulation functions

NICOTINOYL SH-NONAPEPTIDE-3BLEACHING, HUMECTANT, NAIL CONDITIONING, SKIN PROTECTING

NICOTINOYL SH-PENTAPEPTIDE-4BLEACHING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

NICOTINOYL TRANEXAMIC ACIDSKIN CONDITIONING, SKIN PROTECTING

NICOTINOYL TRIPEPTIDE-1ANTIOXIDANT, CHELATING, SKIN PROTECTING

NOCCAEA SYLVIA EXTRACTSKIN PROTECTING

NONAPEPTIDE-10ANTIOXIDANT, CHELATING, SKIN PROTECTING

NONAPEPTIDE-11ANTI-SEBUM, SKIN PROTECTING

NONAPEPTIDE-12HAIR CONDITIONING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How NICTOFLORIN appears in the CosIng inventory

The CosIng inventory lists NICTOFLORIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NICTOFLORIN is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NICTOFLORIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NICTOFLORIN carries the following function designation(s):

CAS 17650-84-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for NICTOFLORIN

This page reproduces the CosIng inventory entry for NICTOFLORIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NICTOFLORIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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