HYDROXYAPATITE
Hydroxylapatite (Ca5(OH)(PO4)3)
HYDROXYAPATITE is linked to 1 EU annex record on this page.
Regulatory evidence by market
This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.
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| Market | Evidence status | Records | Source language |
|---|---|---|---|
| European Union | Evidence linked Restricted entry found Open this evidence | 1 | English and EU languages |
| Great Britain | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Canada | Source mapped Official source mapped; ingredient rule not imported | 0 | English and French |
| New Zealand | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| ASEAN | Source mapped Official source mapped; ingredient rule not imported | 0 | English and national languages |
| China | Source mapped Official source mapped; ingredient rule not imported | 0 | Chinese with selected English material |
| Japan | Source mapped Official source mapped; ingredient rule not imported | 0 | Japanese; official English translation available |
| South Korea | Source mapped Official source mapped; ingredient rule not imported | 0 | Korean with some English names |
| United States | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Australia | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Brazil | Source mapped Official source mapped; ingredient rule not imported | 0 | Portuguese with INCI crosswalks |
| India | Source mapped Official source mapped; ingredient rule not imported | 0 | English and Hindi |
| Saudi Arabia | Evidence linked Restricted Open this evidence | 1 | Arabic and English |
Chemical identity and properties
Hydroxylapatite (Ca5(OH)(PO4)3)
Hydroxylapatite is a mineral with formula of Ca5(PO4)3OH. The corresponding IMA (International Mineralogical Association) number is IMA2010 s.p.. The IMA symbol is Hap. — RRUFF Project
- IUPAC name
- pentacalcium;hydroxide;triphosphate
- Molecular formula
- Ca5HO13P3
- Molecular weight
- 502.3 g/mol
- Exact mass
- 501.675955 Da
- Topological polar surface area
- 260.0 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 13
- Covalent units
- 9
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEMBL:CHEMBL2218916
- EPA DTXSID:DTXSID50872537
- PubMed:22939914
- PubMed:21705322
- PubMed:11518271
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: Hexagonal needles arranged in rosettes Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Finely divided, crystalline, nonstoichiometric material. Source: Hazardous Substances Data Bank (HSDB)
- Density: Density: 3.1 to 3.2 /Apatite/ Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Dry Powder Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Solid; [Merck Index] White suspension; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: Practically insol in water, even when freshly prepared Source: Hazardous Substances Data Bank (HSDB)
- Note: This chemical does not meet GHS hazard criteria for 97.8% (362 of 370) of all reports. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 362 of 370 companies (only 2.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 370 reports by companies from 5 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 362 of 370 reports by companies.; There are 3 notifications provided by 8 of 370 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Note: This chemical does not meet GHS hazard criteria for 94% (188 of 200) of all reports. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 188 of 200 companies (only 6% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 200 reports by companies from 6 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 188 of 200 reports by companies.; There are 3 notifications provided by 12 of 200 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Consumer Uses: Not Known or Reasonably Ascertainable; Filler Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Processing aids not otherwise specified; Filler; Soil amendments (fertilizers); Stabilizing agent Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Naturally occurring mineral in phosphate rocks and in bone; [Merck Index] Used in fertilizers, laser crystals, ion-exchange chromatography (especially for proteins), artificial bone and teeth, and calcium/phosphorus supplement; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Source of phosphorus & phosphoric acid; mfr of fertilizers; laser crystals /Apatite/ Source: Hazardous Substances Data Bank (HSDB)
- Uses: USED IN DENTURE & ORTHOPEDIC MATERIALS; USED IN ION-EXCHANGE CHROMATOGRAPHY ESPECIALLY FOR PROTEINS Source: Hazardous Substances Data Bank (HSDB)
- Uses: MEDICATION Source: Hazardous Substances Data Bank (HSDB)
- Uses: Prosthetic aid (artificial bone and teeth). Source: Hazardous Substances Data Bank (HSDB)
- Uses: For more Uses (Complete) data for HYDROXYAPATITE (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Plastics -> Typical concentration range in plastic materials -> 5% Source: NORMAN Suspect List Exchange
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for HYDROXYAPATITE
INCI name
HYDROXYAPATITE
INN name
durapatite
Description
Hydroxylapatite (Ca5(OH)(PO4)3)
Record provenance
- Inventory reference
- 34479
- Imported identity
- HYDROXYAPATITE
- Source update
- 18/01/2019
Annex records for HYDROXYAPATITE
Key data
- ABRASIVE
- Removing unwanted tissue or foreign materials from various body surfaces, including mechanical tooth cleaning and/or gloss improvement.
- BULKING
- Non-reactive (chemically inert), solid ingredients that dilute other solids and/or increase the volume of cosmetic products.
- ORAL CARE
- Providing cosmetic effects to the oral cavity, e.g. cleansing, deodorising, protecting.
- SKIN CONDITIONING
- Maintaining the skin in good condition.
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Records sharing a CAS or EC identity
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
How HYDROXYAPATITE appears in the CosIng inventory
The CosIng inventory lists HYDROXYAPATITE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.
HYDROXYAPATITE is also tagged with 4 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
Source note for HYDROXYAPATITE
This page combines the CosIng inventory entry for HYDROXYAPATITE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.
Use this inventory page to research HYDROXYAPATITE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
Tools & next steps
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