InventoryRef 3349115/10/2010
DIMETHYL SUCCINATE
Dimethyl succinate
DIMETHYL SUCCINATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
CAS 106-65-0PubChem CID 7820
Dimethyl Succinate
Dimethyl succinate is a colorless liquid. (USCG, 1999) — CAMEO Chemicals
- IUPAC name
- dimethyl butanedioate
- Molecular formula
- C6H10O4
- Molecular weight
- 146.14 g/mol
- Exact mass
- 146.05790880 Da
- XLogP3
- 0.4
- Topological polar surface area
- 52.6 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
DimethylsuccinateButanedioic acid, dimethyl esterSuccinic acid, dimethyl esterMethyl butanedioateFEMA No. 23961,4-dimethyl butanedioateButanedioic acid, 1,4-dimethyl esterNSC-52209
16 more reported names
914I2127JRRefChem:134276203-419-9Methyl succinateSuccinic acid dimethyl esterDBE-4 dibasic esterSuccinic acid-dimethyl esterDBE-4Dimethyl ester of succinic acidCH3OC(O)CH2CH2C(O)OCH3Dimethyl 2,3-butanedioatedimethyl butane-1,4-dioateCAS-106-65-0CCRIS 4803HSDB 5370EINECS 203-419-9
External database identifiers
- ChEBI:CHEBI:165393
- ChEMBL:CHEMBL556489
- EPA DTXSID:DTXSID5025152
- PubMed:23008214
- PubMed:22829187
- PubMed:22781119
- PubMed:22662171
- PubMed:22496810
- PubMed:22364569
- PubMed:22272304
- PubMed:22043288
- PubMed:21947382
- PubMed:21304674
- PubMed:20815381
- PubMed:20497556
Evidence from additional scientific databases
EMBL-EBI ChEBI
Exact identifier matchCHEBI:165393
Dimethyl succinate
- Formula
- C6H10O4
- Average mass
- 146.142 g/mol
- Monoisotopic mass
- 146.05791 Da
- Formal charge
- 0
- fatty acid methyl ester — is a (CHEBI:4986)
- fatty acid methyl ester — is a (CHEBI:4986)
Additional curated names
dimethyl butanedioate
Cross-references from this source
- CAS: 106-65-0 — ChemIDplus
- MANUAL_X_REF: 13848341 — ChemSpider
- MANUAL_X_REF: 9HB — PDBeChem
- MANUAL_X_REF: HMDB0033837 — HMDB
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Exact identifier match7820
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 689 °F (USCG, 1999) Source: CAMEO Chemicals
- Boiling Point: 385.5 °F at 760 mmHg (NTP, 1992) Source: CAMEO Chemicals
- Boiling Point: 195.3 °C @ 760 MM HG Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 195.00 to 197.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 195-196 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Boiling Point: 385.5 °F Source: Occupational Safety and Health Administration (OSHA)
- Boiling Point: 195.3 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Color/Form: COLORLESS LIQ @ ROOM TEMP; SOLIDIFIES WHEN COLD Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.117 (USCG, 1999) - Denser than water; will sink Source: CAMEO Chemicals
- Density: 1.1202 @ 18 °C/4 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.114-1.118 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Density: 1.117 Source: Occupational Safety and Health Administration (OSHA)
- Density: 1.1202 @ 18°C Source: PAC Chemical Database, U.S. Department of Energy
- Flash Point: 185 °F (NTP, 1992) Source: CAMEO Chemicals
- Flash Point: 85.0 °F Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 185 °F Source: Occupational Safety and Health Administration (OSHA)
- LogP: Log Kow = 0.35 Source: Hazardous Substances Data Bank (HSDB)
- LogP: 0.35 Source: Human Metabolome Database (HMDB)
- Melting Point: 67.1 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: 19.5 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 19 °C Source: Human Metabolome Database (HMDB)
- Melting Point: 67.1 °F Source: Occupational Safety and Health Administration (OSHA)
- Melting Point: 19.5 °C Source: PAC Chemical Database, U.S. Department of Energy
- Odor: PLEASANT, ETHEREAL, WINEY ODOR Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Dimethyl succinate is a colorless liquid. (USCG, 1999) Source: CAMEO Chemicals
- Physical Description: CBI; Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Colorless liquid that solidifies at room temperature (19.5 deg C); [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: colourless to pale yellow liquid, solidifying in the cold with pleasant ethereal-winey, slightly fruity odour Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Physical Description: Colorless liquid. Source: Occupational Safety and Health Administration (OSHA)
- Refractive Index: Index of refraction = 1.4197 at 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Refractive Index: 1.418-1.422 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: greater than or equal to 100 mg/mL at 73 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: SOL IN 120 PARTS WATER, 35 PARTS ALC Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Slightly soluble in water, soluble in acetone, ethanol, very soluble in ethyl ether Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 25000 mg/L @ 20 °C (exp) Source: Human Metabolome Database (HMDB)
- Solubility: slightly soluble to soluble in water; slightly soluble in alcohol; miscible in oils Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: 1 mL in 1 mL 95% alcohol (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Vapor Pressure: 0.3 mmHg at 68 °F (NTP, 1992) Source: CAMEO Chemicals
- Vapor Pressure: 0.3 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 0.3 mmHg at 68 °F Source: Occupational Safety and Health Administration (OSHA)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
- Note: This chemical does not meet GHS hazard criteria for 61.8% (730 of 1181) of all reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H319 (36.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1181 reports by companies from 9 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 730 of 1181 reports by companies.; There are 7 notifications provided by 451 of 1181 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: NITE-CMC
- GHS Hazard Statements: H227: Combustible liquid [Warning Flammable liquids]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard] Source: NITE-CMC
- Precautionary Statement Codes: P210, P260, P264+P265, P273, P280, P305+P351+P338, P319, P337+P317, P370+P378, P403, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
- Environmental Bioconcentration: An estimated BCF value of 1.1 was calculated for dimethyl succinate(SRC), using a measured log Kow of 0.35(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 37(SRC), determined from a measured log Kow of 0.35(2) and a recommended regression-derived equation(3), indicates that dimethyl succinate is expected to have very high mobility in soil(SRC). Volatilization of dimethyl succinate from moist soil surfaces(SRC) is not expected to be important given an estimated Henry's Law constant of 6.4X10-8 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Based upon a group contribution method for predicting the probability and rate of aerobic biodegradation(5), dimethyl succinate has been estimated to be highly biodegraded with complete biodegradation occurring over a period of weeks(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 37(SRC), determined from a measured log Kow of 0.35(2) and a recommended regression-derived equation(3), indicates that dimethyl succinate is not expected to adsorb to suspended solids and sediment in water(SRC). Dimethyl succinate is not expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 6.4X10-8 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF value of 1.1(3,SRC), from a measured log Kow(2), suggests that bioconcentration in aquatic organisms is low(SRC). Based upon a group contribution method for predicting the probability and rate of aerobic biodegradation(6), dimethyl succinate has been estimated to be highly biodegraded with complete biodegradation occurring over a period of weeks(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dimethyl succinate, which has an estimated vapor pressure of 0.46 mm Hg at 25 °C(2,SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase dimethyl succinate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 14 days(3,SRC). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Cleaning agent; Not Known or Reasonably Ascertainable; Solvent; Dispersing agent Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Adsorbent; Pigment; Adhesion/cohesion promoter; Intermediate; Processing aids, specific to petroleum production; Viscosity modifiers; Thickening agent; Not Known or Reasonably Ascertainable; Other; Solvent; Dispersing agent Source: EPA Chemical Data Reporting (CDR)
- Cosmetic Ingredient Review Link: CIR ingredient: Dimethyl Succinate Source: Cosmetic Ingredient Review (CIR)
- Sources/Uses: Used as a solvent for fruit flavors and a synthetic flavor; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: SOLVENT FOR FRUIT FLAVORS Source: Hazardous Substances Data Bank (HSDB)
- Uses: SYNTHETIC FLAVOR Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for DIMETHYL SUCCINATE
INCI name
DIMETHYL SUCCINATE
Description
Dimethyl succinate
Record provenance
- Inventory reference
- 33491
- Imported identity
- DIMETHYL SUCCINATE
- Source update
- 15/10/2010
Annex records for DIMETHYL SUCCINATE
Key data
CAS
EC
Restriction
—
Function
- FRAGRANCE
- Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
- SKIN CONDITIONING
- Maintaining the skin in good condition.
- SKIN CONDITIONING - EMOLLIENT
- Acting as lubricants on the skin surface providing the skin with a soft and smooth appearance.
- SOLVENT
- Dissolving other components of cosmetics. Solvents are usually liquids (aqueous and nonaqueous).
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal
How DIMETHYL SUCCINATE appears in the CosIng inventory
The CosIng inventory lists DIMETHYL SUCCINATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
DIMETHYL SUCCINATE is also tagged with 4 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
DIMETHYL SUCCINATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.
According to the EU CosIng inventory, DIMETHYL SUCCINATE carries the following function designation(s):
CAS 106-65-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Source note for DIMETHYL SUCCINATE
This page reproduces the CosIng inventory entry for DIMETHYL SUCCINATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research DIMETHYL SUCCINATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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