Official EU label nameGlossary entry 3367

BETULINIC ACID

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

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Resolved identifiers

Resolved substance identity

CAS:472-15-1

EC:207-448-8

Ingredient index records:

BETULINIC ACID

Cosmetic functions: SKIN CONDITIONING

Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3beta)-

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1 matched or reported name

BETULINIC ACID

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name BETULINIC ACID.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 472-15-1

CAS 472-15-1PubChem CID 64971

Betulinic Acid

Betulinic acid is a pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium claviflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties. It has a role as an antineoplastic agent, an antimalarial, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an anti-HIV agent, an anti-inflammatory agent and a plant metabolite. It is a pentacyclic triterpenoid and a hydroxy monocarboxylic acid. It derives from a hydride of a lupane. — ChEBI

IUPAC name: (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid

Molecular formula: C30H48O3
Molecular weight: 456.7 g/mol
Exact mass: 456.36034539 Da
XLogP3: 8.2
Topological polar surface area: 57.5 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 10

Also known as

MairinBetulic acidLupatic Acidals-3573-Hydroxylup-20(29)-en-28-oic acidbeta-betulinic acidNSC-113090NSC-677578

16 more reported names

3beta-Hydroxy-lup-20(29)-en-28-oic acid4G6A18707NCHEBI:30873 Epi betulinic AcidRefChem:56063-Hydroxy-lup-20(29)-en-28-oic Acid(3beta)-3-Hydroxy-lup-20(29)-en-28-oic Acid207-448-8Betulinicacid.beta.-betulinic acidPrestwick0_000417Prestwick3_000417Lupatic acid;Betulic acid(3beta)-3-hydroxylup-20(29)-en-28-oic acid3beta-Hydroxy-20(29)-lupaene-28-oic acid3beta-hydroxylup-20(29)-en-28-oic acid

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External database identifiers

ChEBI:CHEBI:3087
ChEMBL:CHEMBL269277
EPA DTXSID:DTXSID80861974
PubMed:24623716
PubMed:23821410
PubMed:23399723
PubMed:23122155
PubMed:23122121
PubMed:23114617
PubMed:23112419
PubMed:23085651
PubMed:23056140
PubMed:23019882
PubMed:23017402
PubMed:23017394

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

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Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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