Official EU label nameGlossary entry 3366

BETULIN

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

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Evidence gaps

Resolved identifiers

Resolved substance identity

CAS:473-98-3

EC:207-475-5

Ingredient index records:

BETULIN

Cosmetic functions: SKIN CONDITIONING

Lup-20(29)-ene-3,28-diol, (3β)-

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1 matched or reported name

BETULIN

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name BETULIN.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 473-98-3

CAS 473-98-3PubChem CID 72326

Betulin

Betulin is a pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents. It has a role as an antiviral agent, a metabolite, an analgesic, an antineoplastic agent and an anti-inflammatory agent. It is a diol and a pentacyclic triterpenoid. It derives from a hydride of a lupane. — ChEBI

IUPAC name: (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-ol

Molecular formula: C30H50O2
Molecular weight: 442.7 g/mol
Exact mass: 442.381080833 Da
XLogP3: 8.3
Topological polar surface area: 40.5 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 10

Also known as

BetulinolTrocholBetulineBetulolBetulinic alcohol(+)-betulinLup-20(30)-ene-3beta,28-diolCP BETULIN

16 more reported names

NSC-46446W70HN7X7OORISTRACT BTLLup-20(29)-ene-3,28-diol, (3beta)-lup-20(29)-ene-3 beta,28-diolCHEBI:3086RefChem:568020lup-20(29)-ene-3,28-diol, 3,28-diacetate, (3 beta)-207-475-5Lup-20(29)-ene-3b,28-diolNSC 4644Betulinol (obsol.)(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(Hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-olAI3-62999ACon1_000091Lup-20(30)-ene-3.beta.,28-diol

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External database identifiers

ChEBI:CHEBI:3086
ChEMBL:CHEMBL23236
EPA DTXSID:DTXSID101019934
PubMed:23113303
PubMed:23085649
PubMed:23017394
PubMed:22997710
PubMed:22987400
PubMed:22978211
PubMed:22978210
PubMed:22976320
PubMed:22924053
PubMed:22864237
PubMed:22856149
PubMed:22808999

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

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Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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