Is BETULINIC ACID safe to use in EU cosmetics?

BETULINIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 472-15-1?

CAS 472-15-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 8354115/10/2010

BETULINIC ACID

Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3beta)-

BETULINIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 472-15-1

CAS 472-15-1PubChem CID 64971

Betulinic Acid

Betulinic acid is a pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium claviflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties. It has a role as an antineoplastic agent, an antimalarial, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an anti-HIV agent, an anti-inflammatory agent and a plant metabolite. It is a pentacyclic triterpenoid and a hydroxy monocarboxylic acid. It derives from a hydride of a lupane. — ChEBI

IUPAC name: (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid

Molecular formula: C30H48O3
Molecular weight: 456.7 g/mol
Exact mass: 456.36034539 Da
XLogP3: 8.2
Topological polar surface area: 57.5 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 10

Also known as

MairinBetulic acidLupatic Acidals-3573-Hydroxylup-20(29)-en-28-oic acidbeta-betulinic acidNSC-113090NSC-677578

16 more reported names

3beta-Hydroxy-lup-20(29)-en-28-oic acid4G6A18707NCHEBI:30873 Epi betulinic AcidRefChem:56063-Hydroxy-lup-20(29)-en-28-oic Acid(3beta)-3-Hydroxy-lup-20(29)-en-28-oic Acid207-448-8Betulinicacid.beta.-betulinic acidPrestwick0_000417Prestwick3_000417Lupatic acid;Betulic acid(3beta)-3-hydroxylup-20(29)-en-28-oic acid3beta-Hydroxy-20(29)-lupaene-28-oic acid3beta-hydroxylup-20(29)-en-28-oic acid

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:3087
ChEMBL:CHEMBL269277
EPA DTXSID:DTXSID80861974
PubMed:24623716
PubMed:23821410
PubMed:23399723
PubMed:23122155
PubMed:23122121
PubMed:23114617
PubMed:23112419
PubMed:23085651
PubMed:23056140
PubMed:23019882
PubMed:23017402
PubMed:23017394

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for BETULINIC ACID

INCI name

BETULINIC ACID

Description

Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3beta)-

Record provenance

Inventory reference: 83541
Imported identity: BETULINIC ACID
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for BETULINIC ACID

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Key data

CAS

472-15-1

207-448-8

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#3367 · BETULINIC ACID

Ingredients with overlapping formulation functions

BETULA PLATYPHYLLA JAPONICA BARK EXTRACTSKIN CONDITIONING

BETULA PLATYPHYLLA JAPONICA JUICESKIN CONDITIONING

BETULA PLATYPHYLLA JAPONICA LEAF EXTRACTSKIN CONDITIONING

BETULINSKIN CONDITIONING

BETULINIC PEG-44 AMIDE METHYL ETHERSKIN CONDITIONING

BETULINYL METHOXY PEG-22 CARBOXYLATESKIN CONDITIONING

BIDENS PILOSA EXTRACTHUMECTANT, SKIN CONDITIONING

BIDENS TRIPARTITA FLOWER/LEAF/STEM EXTRACTSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How BETULINIC ACID appears in the CosIng inventory

The CosIng inventory lists BETULINIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

BETULINIC ACID is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

BETULINIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, BETULINIC ACID carries the following function designation(s):

SKIN CONDITIONING

CAS 472-15-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for BETULINIC ACID

This page reproduces the CosIng inventory entry for BETULINIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research BETULINIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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