Official EU label nameGlossary entry 24381
RIBOFLAVIN
This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.
Global evidence snapshot
The resolved identity has matching regulatory evidence in 3 of 13 indexed market datasets: 2 country records and 1 EU Annex records. Every result and evidence gap is listed below.
Markets checked
13
Markets with evidence
3
Evidence gaps
10
Resolved identifiers
4
A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.
Resolved substance identity
CAS:83-88-5130-40-5
EC:201-507-1204-988-6
Ingredient index records:
RIBOFLAVIN
Ph. Eur. name: riboflavinum
Cosmetic functions: COLORANT, SKIN CONDITIONING - MISCELLANEOUS
Riboflavin
Inventory restriction note: IV/145
SODIUM RIBOFLAVIN PHOSPHATE
Ph. Eur. name: riboflavini natrii phosphas
Cosmetic functions: SKIN CONDITIONING
Riboflavin 5'-(sodium hydrogen phosphate)
11 matched or reported names
RIBOFLAVINriboflavinriboflavinumLACTOFLAVINRiboflavin [USAN:INN:JAN]SODIUM RIBOFLAVIN PHOSPHATEriboflavin 5'-phosphate sodiumriboflavini natrii phosphasRiboflavinLactoflavinRiboflavin (lactoflavin, vitamin B2)
Regulatory evidence in all 13 markets
Open each matched record for its scope, concentration, conditions, warnings and official source version.
Swipe or scroll horizontally to see dataset coverage and next actions.
| Market | Result | Records | Dataset | Meaning / next action |
|---|---|---|---|---|
| European Union EU | Conditional positive-list match | 1Open record 1 | Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026 | Review every linked record and exact conditions. |
| Great Britain GB | Permitted list with conditions | 1Open record 1 | Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026 | Review every linked record and exact conditions. |
| Canada CA | No local match | 0 | Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025 | The Hotlist is an administrative compliance tool, not an exhaustive safety approval list. |
| New Zealand NZ | Permitted list with conditions | 1Open record 1 | Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026 | Review every linked record and exact conditions. |
| ASEAN ASEAN | No local match | 0 | Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026 | Regional annex coverage does not replace member-state implementation dates, notifications or national deviations. |
| China CN | No local match | 0 | Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025 | IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately. |
| Japan JP | No local match | 0 | Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot | The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion. |
| South Korea KR | No local match | 0 | Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026 | Korean source wording is canonical and other positive lists/notices may still apply to the formulation. |
| United States US | No local match | 0 | Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026 | FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety. |
| Australia AU | No local match | 0 | Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026 | An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction. |
| Brazil BR | No local match | 0 | Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026 | RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026. |
| India IN | No local match | 0 | Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022) | The standards are separate controlled publications; absence from a locally indexed excerpt is not permission. |
| Saudi Arabia SA | No local match | 0 | Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026 | No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply. |
No market rows match this filter.
Matching market records and conditions
Great Britain
GB retained Regulation 1223/2009 schedules, effective 15 August 2026New Zealand
Cosmetic Products Group Standard schedules effective 1 January 2026Exact Annex II–VI evidence
Annex IVentry 145
Open full regulatory recordLACTOFLAVIN / RIBOFLAVIN
Warnings: Purity criteria as set out in Commission Directive 95/45/EC (E101)
Chemical identity and properties
CAS 130-40-5PubChem CID 23666409
Riboflavin sodium phosphate
- IUPAC name
- sodium [(2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] hydrogen phosphate
- Molecular formula
- C17H20N4NaO9P
- Molecular weight
- 478.3 g/mol
- Exact mass
- 478.08655951 Da
- Topological polar surface area
- 204.0 Ų
- Hydrogen-bond donors
- 5
- Hydrogen-bond acceptors
- 10
- Covalent units
- 2
- Defined stereocentres
- 3
Also known as
RIBOFLAVIN PHOSPHATE SODIUMRiboflavin-5-phosphate sodiumRiboflavin 5'-monophosphate sodium saltRiboflavina 5 fosfato de sodioRiboflavine-5'-phosphate sodiumRiboflavin 5'-phosphate sodium anhydrousRiboflavin 5'-(dihydrogen phosphate), sodium salt (1:1)Flavin Mononucleotide Sodium Salt
16 more reported names
Sodium Riboflavin PhosphateRIBOFLAVIN 5-PHOSPHATE SODIUMRiboflavin (phosphate sodium)957E53WV42NSC 759230Riboflavin monophosphate monosodium saltSodium (2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-2,3,4-trihydroxypentyl hydrogen phosphateFMN-NaFLAVIN MONONUCLEOTIDE MONOSODIUM SALT [MI]Riboflavin sodium phosphate [JAN]Lactoflavin Phosphate Sodium SaltRiboflavin 5'-(dihydrogen phosphate), monosodium saltRiboflavin Phosphate Sodium Salt (~70%)Riboflavin-5'-phosphate sodiumRiboflavin Phosphate Sodium SaltRiboflavin sodium phosphate; riboflavin 5'-(sodium hydrogen phosphate)
External database identifiers
- ChEBI:CHEBI:32098
- EPA DTXSID:DTXSID80889330
- PubMed:5053
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match23666409
Attributed physical-property, hazard, environmental and use annotations.
- Physical Description: Exists as the dihydrate: Yellow solid; [Merck Index] Yellow to orange hygroscopic solid; [JECFA] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Note: This chemical does not meet GHS hazard criteria for 97% (65 of 67) of all reports. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 65 of 67 companies (only 3% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 67 reports by companies from 2 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 65 of 67 reports by companies.; There is 1 notification provided by 2 of 67 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Sources/Uses: A bioactive form of riboflavin; [Merck Index] Used as a nutritional supplement; [FDA] Used as a coloring agent for foods; [JECFA] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
CAS 83-88-5PubChem CID 493570
Riboflavin
Riboflavin is D-Ribitol in which the hydroxy group at position 5 is substituted by a 7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl moiety. It is a nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables, but the richest natural source is yeast. The free form occurs only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. It has a role as an antioxidant, a cofactor, a photosensitizing agent, an anti-inflammatory agent, a mouse metabolite, a plant metabolite, an Escherichia coli metabolite, a food colouring, a fundamental metabolite and a human urinary metabolite. It is a vitamin B2 and a flavin. It is a conjugate acid of a riboflavin(1-). — ChEBI
- IUPAC name
- 7,8-dimethyl-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dione
- Molecular formula
- C17H20N4O6
- Molecular weight
- 376.4 g/mol
- Exact mass
- 376.13828437 Da
- XLogP3
- -1.5
- Topological polar surface area
- 155.0 Ų
- Hydrogen-bond donors
- 5
- Hydrogen-bond acceptors
- 7
- Covalent units
- 1
- Defined stereocentres
- 3
Also known as
vitamin B2RiboflavineLactoflavinVitamin GLactoflavineFlavaxinBeflavineBeflavin
16 more reported names
RibodermRibipcaRibovelLactobeneRibocrisinaRiboflavinaRiboflavinumRibotoneVitaflavineFlaxainRibosynVitamin BiFlavin BBRussupteridine Yellow IIIVitasan B2HYRE
External database identifiers
- ChEBI:CHEBI:17015
- ChEMBL:CHEMBL1534
- EPA DTXSID:DTXSID8021777
- PubMed:37944868
- PubMed:34062077
- PubMed:33882315
- PubMed:33352258
- PubMed:26360969
- PubMed:23105845
- PubMed:23074417
- PubMed:23063183
- PubMed:23062003
- PubMed:23062001
- PubMed:23056435
- PubMed:23056269
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Additional authoritative substance research
These source-specific lookups can add hazard, toxicology, identity and assessment context. A link is a research route, not a claim that the source contains an exact record.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identityFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identityILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identityJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identityNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identityOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identityUS EPA CompTox CTX APIs
DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identityContinue the compliance check
1. Confirm identity
Match the supplier specification, CAS/EC identifiers and composition to this official label name. Similar wording is not proof of chemical equivalence.
2. Review restrictions
Check every exact Annex record shown above, plus CMR, nanomaterial, SCCS and later-amendment requirements that may apply.
3. Verify the formula
Evaluate concentration, product type, purity, warnings, claims and each target market before making a compliance decision.
Official source and scope
Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.
Open official Decision