Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
Annex V Entry 58 27/07/2020

Ethyl-N-alpha-dodecanoyl-L-arginate hydrochloride

Ethyl-N-alpha-dodecanoyl-L-arginate hydrochloride appears in Annex V as a positive-list preservative entry for EU cosmetics. Maximum concentration in this record: (a) 0,15 % (b) 0,4 %.

Search similar Back to annex Compare Calculate concentration
Permitted preservative— Annex V, EU Regulation 1223/2009
Max conc.: (a) 0,15 % (b) 0,4 %
Entry: 58

Chemical identity and properties

PubChem 2D chemical structure for CAS 60372-77-2
CAS 60372-77-2PubChem CID 25229630

Ethyl-Nalpha-lauroyl-L-arginate hydrochloride

IUPAC name
ethyl (2S)-5-(diaminomethylideneamino)-2-(dodecanoylamino)pentanoate;hydrochloride
Molecular formula
C20H41ClN4O3
Molecular weight
421.0 g/mol
Exact mass
420.2867189 Da
Topological polar surface area
120.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
4
Covalent units
2
Defined stereocentres
1

Also known as

Ethyl lauroyl arginate hydrochlorideEthyl lauroyl arginate HClCytoguard LAXPD6ZY79TBAMINAT GL-Arginine, N2-(1-oxododecyl)-, ethyl ester, monohydrochlorideE-243RefChem:596249
16 more reported names
434-630-6L-Arginine, N2-(1-oxododecyl)-, ethyl ester, hydrochloride (1:1)(S)-Ethyl 2-dodecanamido-5-guanidinopentanoate hydrochlorideUNII-XPD6ZY79TBLAEC20H41ClN4O3MIRENAT CFethyl (2S)-5-(diaminomethylideneamino)-2-(dodecanoylamino)pentanoate,hydrochlorideLAURIC ARGINATE ETHYL ESTEREINECS 434-630-6LAURAMIDE ARGININE ETHYL ESTERBS-17290DA-53037ethyl-n-dodecanoyl-l-arginate hydrochlorideLAURAMIDE ARGININE ETHYL ESTER (LAE)Ethyl N2-dodecanoyl-L-argininate hydrochloride
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

(a) 0,15 % (b) 0,4 %

Product type

Mouthwashes Other products

Other restrictions

(a) Not to be used in preparations for children under 10 years of age

(b) Not to be used in lip products, oral products (other than mouthwashes), and spray products

Warnings

(a) Not to be used for children under 10 years of age

Chemical name

Ethyl-N-alpha-dodecanoyl-L-arginate hydrochloride

Chemical / IUPAC name

Ethyl-N-alpha-dodecanoyl-L-arginate hydrochloride

Regulatory information

Regulation

(EU) 2016/1121

See every entry this act set

SCCS opinions

  • ADDENDUM to the Opinion on Ethyl lauroyl arginate HCl - SCCS/1519/13

Key data

CAS
60372-77-2
EC
434-630-6
Annex
V
Entry number
58

Inventory links for Ethyl-N-alpha-dodecanoyl-L-arginate hydrochloride

Annex III 321
Shared product type

TITANIUM DIOXIDE

CAS: 13463-67-7/ 1317-70-0/ 1317-80-2
EC: 236-675-5/ 215-280-1/ 215-282-2
Annex III 59
Shared product type

TALC

CAS: 14807-96-6
EC: 238-877-9

What Annex V means for Ethyl-N-alpha-dodecanoyl-L-arginate hydrochloride

Ethyl-N-alpha-dodecanoyl-L-arginate hydrochloride is an approved preservative listed in Annex V of EU Cosmetics Regulation 1223/2009. Only substances on this positive list may be used as cosmetic preservatives in the EU.

Each preservative entry specifies maximum permitted concentrations and applicable product scope. Concentrations must not exceed the listed maximum. Some preservatives require warning statements on the product label.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Use concentration must not exceed: (a) 0,15 % (b) 0,4 %
  • Verify the preservative is effective at the permitted concentration for your matrix.
  • Apply required label warning statement.

Frequently asked questions

Yes. Ethyl-N-alpha-dodecanoyl-L-arginate hydrochloride is listed in Annex V of EU Cosmetics Regulation 1223/2009 as a permitted preservative. It may be used in cosmetics up to the maximum concentration specified above, within the permitted product scope.

CAS 60372-77-2 is the unique numerical identifier assigned to Ethyl-N-alpha-dodecanoyl-L-arginate hydrochloride by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of (a) 0,15 % (b) 0,4 % applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Open INCI Checker

Source note for Annex V record Ethyl-N-alpha-dodecanoyl-L-arginate hydrochloride

This page summarizes one Annex V record for Ethyl-N-alpha-dodecanoyl-L-arginate hydrochloride from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex V conditions for Ethyl-N-alpha-dodecanoyl-L-arginate hydrochloride, but confirm any final regulatory decision against the current official annex wording and source files.

View sourcesView updates

Tools & next steps

Check your formula

Paste a full INCI list to detect Ethyl-N-alpha-dodecanoyl-L-arginate hydrochloride and other flagged EU annex records in one pass.

INCI Checker

Compare entries

Compare Ethyl-N-alpha-dodecanoyl-L-arginate hydrochloride side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Compare

Browse the annex

See all records in Annex V and compare regulatory conditions across substances in this annex.

Open Annex V