Why does CAS 60372-77-2 appear in more than one EU cosmetic annex?

A substance identified by CAS 60372-77-2 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 60372-77-2?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 60372-77-2 to screen it directly, then review every linked annex record and supplier document.

CAS 2 records

CAS 60372-77-2

Q: How do I use CAS 60372-77-2 for compliance screening?

Cross-reference CAS 60372-77-2 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 60372-77-2 matches 2 EU annex records across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 60372-77-2

CAS 60372-77-2PubChem CID 25229630

Ethyl-Nalpha-lauroyl-L-arginate hydrochloride

IUPAC name: ethyl (2S)-5-(diaminomethylideneamino)-2-(dodecanoylamino)pentanoate;hydrochloride

Molecular formula: C20H41ClN4O3
Molecular weight: 421.0 g/mol
Exact mass: 420.2867189 Da
Topological polar surface area: 120.0 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 4
Covalent units: 2
Defined stereocentres: 1

Also known as

Ethyl lauroyl arginate hydrochlorideEthyl lauroyl arginate HClCytoguard LAXPD6ZY79TBAMINAT GL-Arginine, N2-(1-oxododecyl)-, ethyl ester, monohydrochlorideE-243RefChem:596249

16 more reported names

434-630-6L-Arginine, N2-(1-oxododecyl)-, ethyl ester, hydrochloride (1:1)(S)-Ethyl 2-dodecanamido-5-guanidinopentanoate hydrochlorideUNII-XPD6ZY79TBLAEC20H41ClN4O3MIRENAT CFethyl (2S)-5-(diaminomethylideneamino)-2-(dodecanoylamino)pentanoate,hydrochlorideLAURIC ARGINATE ETHYL ESTEREINECS 434-630-6LAURAMIDE ARGININE ETHYL ESTERBS-17290DA-53037ethyl-n-dodecanoyl-l-arginate hydrochlorideLAURAMIDE ARGININE ETHYL ESTER (LAE)Ethyl N2-dodecanoyl-L-argininate hydrochloride

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID40209136

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 60372-77-2

2 total

Annex

III

Entry

197

ETHYL LAUROYL ARGINATE HCL

Ethyl Lauroyl Arginate HCl

For purposes other than inhibiting the development of micro- organisms in the product. This purpose has to be apparent from the presentation of the product

434-630-6

Max concentration

Annex

Entry

Ethyl-N-alpha-dodecanoyl-L-arginate hydrochloride

(a) Not to be used for children under 10 years of age

434-630-6

Max concentration

How CAS 60372-77-2 is used on this site

CAS 60372-77-2 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 2 EU annex records share this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 60372-77-2 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 60372-77-2 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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