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Annex III Entry 157 15/09/2023

Alpha-Damascone/cis-Rose ketone 1/trans-Rose ketone 1; Rose ketone 4 (Damascone); Rose ketone 3 (delta-Damascone)/trans-Rose ketone 3; cis-Rose ketone 2 (cis-beta-Damascone); trans-Rose ketone 2 (trans-beta-Damascone)

1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethylcyclohexa-1,3-dien-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethyl-3-cyclohexen-1-yl)-2-buten-1-one; (Z)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-buten-1-one; (E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one

Alpha-Damascone/cis-Rose ketone 1/trans-Rose ketone 1; Rose ketone 4 (Damascone); Rose ketone 3 (delta-Damascone)/trans-Rose ketone 3; cis-Rose ketone 2 (cis-beta-Damascone); trans-Rose ketone 2 (trans-beta-Damascone) is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: (b) 0.02%.

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Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: (b) 0.02%
Entry: 157

Chemical identity and properties

PubChem 2D chemical structure for CAS 23696-85-7
CAS 23696-85-7PubChem CID 5366074

beta-Damascenone

1-[2,6,6-Trimethyl-1,3-cyclohexadien-1-yl]-2-buten-1-one is a metabolite found in or produced by Saccharomyces cerevisiae. — Yeast Metabolome Database (YMDB)

IUPAC name
(E)-1-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)but-2-en-1-one
Molecular formula
C13H18O
Molecular weight
190.28 g/mol
Exact mass
190.135765193 Da
XLogP3
3.2
Topological polar surface area
17.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

trans-beta-Damascenonetrans-damascenone(E)-beta-damascenoneFEMA No. 3420(E)-1-(2,6,6-Trimethyl-1,3-cyclohexadien-1-yl)-2-buten-1-oneU66V25TBO04-(2,6,6-Trimethylcyclohexa-1,3-dienyl)but-2-en-4-oneCHEBI:67251
16 more reported names
1-[2,6,6-Trimethyl-1,3-cyclohexadien-1-yl]-2E-buten-1-one1-(2,6,6-Trimethyl-1,3-cyclohexadien-1-yl)-2E-buten-1-oneRefChem:567817245-833-2245-844-2.beta.-Damascenone2-BUTEN-1-ONE, 1-(2,6,6-TRIMETHYL-1,3-CYCLOHEXADIEN-1-YL)-1-(2,6,6-Trimethyl-1,3-cyclohexadien-1-yl)-2-buten-1-one1-(2,6,6-Trimethylcyclohexa-1,3-dien-1-yl)but-2-en-1-onebeta-(E)-damascenone(E)-.beta.-Damascenone(2E)-1-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)but-2-en-1-one(2E)-1-(2,6,6-Trimethyl-1,3-cyclohexadien-1-yl)-2-buten-1-one2-Buten-1-one, 1-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-, (E)-2-Buten-1-one, 1-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-, (2E)-2-Buten-1-one,1-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-, (2E)-
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 23726-91-2
CAS 23726-91-2PubChem CID 5374527

beta-DAMASCONE

4-(2,6,6-Trimethylcyclohex-1-enyl)but-2-en-4-one is an enone. — ChEBI

IUPAC name
(E)-1-(2,6,6-trimethylcyclohexen-1-yl)but-2-en-1-one
Molecular formula
C13H20O
Molecular weight
192.30 g/mol
Exact mass
192.151415257 Da
XLogP3
3.5
Topological polar surface area
17.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

Damasione4-(2,6,6-Trimethylcyclohex-1-enyl)but-2-en-4-one(2E)-1-(2,6,6-trimethylcyclohex-1-en-1-yl)but-2-en-1-oneJ131X1Y3REDORINONERefChem:1079676DIHYDRO FLORIFFONE B620-561-0
16 more reported names
245-842-1E-beta-damasconedamascone(E)-beta-DamasconeFEMA 3243(E)-1-(2,6,6-Trimethylcyclohex-1-en-1-yl)but-2-en-1-oneUNII-J131X1Y3RE2-Buten-1-one, 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-(E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one2-Buten-1-one, 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (2E)-2376-92-3(E)-1-(2,6,6-Trimethylcyclohex-1-enyl)-2-buten-1-oneI75J0X33Q6Rose dihydroketonetrans-beta-Damasconebeta-Damascone, (E)-
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 23726-92-3
CAS 23726-92-3PubChem CID 1616260

beta-Damascone, (Z)-

IUPAC name
(Z)-1-(2,6,6-trimethylcyclohexen-1-yl)but-2-en-1-one
Molecular formula
C13H20O
Molecular weight
192.30 g/mol
Exact mass
192.151415257 Da
XLogP3
3.5
Topological polar surface area
17.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

(Z)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one(Z)-beta-damascone074X5R04IQEINECS 245-843-72-Buten-1-one, 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (Z)-(Z)-.BETA.-DAMASCONE.BETA.-DAMASCONE, (Z)-FEMA NO. 3243, Z-
13 more reported names
cis-2-Buten-1-one, 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-RefChem:567819(2Z)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one245-843-7Z-beta-damascone(Z)-1-(2,6,6-Trimethylcyclohex-1-en-1-yl)but-2-en-1-one(2Z)-1-(2,6,6-TRIMETHYLCYCLOHEX-1-EN-1-YL)BUT-2-EN-1-ONEFEMA No. 3243UNII-074X5R04IQcis-beta-damascone(Z)-beta-Damascone Analyticalcis-2,6,6-trimethyl-1-crotonyl-1-cyclohexenecis-2,6,6-trimethyl-1-crotonoyl-1-cyclohexene
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 24720-09-0
CAS 24720-09-0PubChem CID 5366077

(E)-1-(2,6,6-trimethylcyclohex-2-en-1-yl)but-2-en-1-one

1-(2,6,6-trimethylcyclohex-2-en-1-yl)but-2-enone is an enone with a trimethylcyclohexenyl substituent at C-1. It has a role as a fragrance and an allergen. — ChEBI

IUPAC name
(E)-1-(2,6,6-trimethylcyclohex-2-en-1-yl)but-2-en-1-one
Molecular formula
C13H20O
Molecular weight
192.30 g/mol
Exact mass
192.151415257 Da
XLogP3
3.2
Topological polar surface area
17.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

1-(2,6,6-trimethylcyclohex-2-en-1-yl)but-2-en-1-one(+/-)-alpha-DAMASCONE1-(2,6,6-TRIMETHYL-CYCLOHEX-2-ENYL)-BUT-2-EN-1-ONE(2E)-1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-buten-1-one(2E)-1-(2,6,6-trimethylcyclohex-2-en-1-yl)but-2-en-1-one2-Buten-1-one, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-, (E)-trans-.alpha.-Damascone1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-2-buten-1-one
16 more reported names
(E)-.alpha.-Damascone(e)-alpha-damasconeMDD00FOW8JCHEBI:53220trans-2-Buten-1-one, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-1-(2,6,6-trimethylcyclohex-2-en-1-yl)but-2-enonetrans-2,6,6-trimethyl-1-crotonoyl-2-cyclohexene1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-trans-2-Buten-1-one2-Buten-1-one, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-, (2E)-alpha-Damascone, (E)-UNII-MDD00FOW8JUNII-UP5JTZ982I1-[2,6,6-Trimethyl-2-cyclohexen-1-yl]-2-buten-1-onealpha-damasconDamascone alphaDamascone, alpha-
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 43052-87-5
CAS 43052-87-5PubChem CID 520506

alpha-Damascone

IUPAC name
1-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-1-one
Molecular formula
C13H20O
Molecular weight
192.30 g/mol
Exact mass
192.151415257 Da
XLogP3
3.2
Topological polar surface area
17.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

RefChem:555689620-558-42-Buten-1-one, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-FEMA No. 3659UP5JTZ982I.alpha.-Damascone1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-3-buten-1-oneGCGZDUFEEQNVPR-UHFFFAOYSA-N
1 more reported name
1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-3-buten-1-one #
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 57378-68-4
CAS 57378-68-4PubChem CID 5365916

Delta-Damascone

IUPAC name
(E)-1-(2,6,6-trimethylcyclohex-3-en-1-yl)but-2-en-1-one
Molecular formula
C13H20O
Molecular weight
192.30 g/mol
Exact mass
192.151415257 Da
XLogP3
3.4
Topological polar surface area
17.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

8-DamasconeDelta Damascone.delta.-DamasconeFEMA No. 3622trans-delta-damascone2-BUTEN-1-ONE, 1-(2,6,6-TRIMETHYL-3-CYCLOHEXEN-1-YL)-EINECS 275-156-87F4RIE5P7E
16 more reported names
DAMASCONE, .DELTA.-(2E)-1-(2,6,6-trimethylcyclohex-3-en-1-yl)but-2-en-1-oneDELTA-DAMASCONE [USP-RS].DELTA.-DAMASCONE [FHFI]Damascone, delta-BRN 1939321EINECS 260-709-8(E)-1-(2beta,6,6-Trimethyl-3-cyclohexen-1alpha-yl)-2-butene-1-one2-Buten-1-one, 1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-, (2E)-DELTA-DAMASCONE (USP-RS)2-Buten-1-one, 1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-, (1alpha(E),2beta)-RefChem:585682DELTA-DAMASCONE [INCI]2-Buten-1-one, 1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-, [1.alpha.(E),2.beta.]-260-709-81-(2,6,6-trimethyl-3-cyclohexen-1-yl)-2-buten-1-one
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 71048-82-3
CAS 71048-82-3PubChem CID 42296

1-(2,6,6-Trimethylcyclohex-3-en-1-yl)but-2-en-1-one

IUPAC name
1-(2,6,6-trimethylcyclohex-3-en-1-yl)but-2-en-1-one
Molecular formula
C13H20O
Molecular weight
192.30 g/mol
Exact mass
192.151415257 Da
XLogP3
3.4
Topological polar surface area
17.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

d-damasconeUNII-7F4RIE5P7EDB-3003871-(2,6,6-trimethylcyclohex-3-enyl)but-2-en-1-one1-(2,6,6-trimethyl-cyclohex-3-enyl)-but-2-en-1-one
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

(b) 0.02%

Product type

Oral products Other products

Other restrictions

(a) (b)
The presence of the substance or substances shall be indicated as ‘Rose Ketones’ in the list of ingredients referred to in Article 19(1), point (g), when the concentration of the substance or substances exceeds:
— 0,001 % in leave-on products
— 0,01 % in rinse-off products.

INCI glossary name

Alpha-Damascone/cis-Rose ketone 1/trans-Rose ketone 1; Rose ketone 4 (Damascone); Rose ketone 3 (delta-Damascone)/trans-Rose ketone 3; cis-Rose ketone 2 (cis-beta-Damascone); trans-Rose ketone 2 (trans-beta-Damascone)

Chemical name

1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethylcyclohexa-1,3-dien-1-yl)-2-buten-1-one; 1-(2,6,6-Trimethyl-3-cyclohexen-1-yl)-2-buten-1-one; (Z)-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-buten-1-one; (E)-1-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one

Regulatory information

Regulation

(EU) 2023/1545

See every entry this act set

Identified ingredients

Key data

CAS
43052-87-5/ 23726-94-5/24720-09-0; 23696-85-7; 57378-68-4/ 71048-82-3; 23726-92-3; 23726-91-2
EC
-/ 245-845-8/ 246-430-4; 245-833-2; 260-709-8/ 275-156-8; 245-843-7; 245-842-1
Annex
III
Entry number
157

Inventory links for Alpha-Damascone/cis-Rose ketone 1/trans-Rose ketone 1; Rose ketone 4 (Damascone); Rose ketone 3 (delta-Damascone)/trans-Rose ketone 3; cis-Rose ketone 2 (cis-beta-Damascone); trans-Rose ketone 2 (trans-beta-Damascone)

Inventory Restriction reference
Ref 54360

ALPHA-DAMASCONE

CAS: 23726-94-5 / 43052-87-5
EC: 245-845-8
Inventory Identified ingredient
Ref 87298

DELTA-DAMASCONE

CAS: 57378-68-4
EC: 260-709-8
Inventory Shared CAS number
Ref 41491

ROSE KETONE-3

CAS: 57378-68-4
EC: 260-709-8
Inventory Shared CAS number
Ref 41492

ROSE KETONE-4

CAS: 23696-85-7
EC: 245-833-2

What Annex III means for Alpha-Damascone/cis-Rose ketone 1/trans-Rose ketone 1; Rose ketone 4 (Damascone); Rose ketone 3 (delta-Damascone)/trans-Rose ketone 3; cis-Rose ketone 2 (cis-beta-Damascone); trans-Rose ketone 2 (trans-beta-Damascone)

Alpha-Damascone/cis-Rose ketone 1/trans-Rose ketone 1; Rose ketone 4 (Damascone); Rose ketone 3 (delta-Damascone)/trans-Rose ketone 3; cis-Rose ketone 2 (cis-beta-Damascone); trans-Rose ketone 2 (trans-beta-Damascone) is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 7 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: (b) 0.02%
  • Confirm product type compatibility: (a) Oral products (b) Other products
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

Alpha-Damascone/cis-Rose ketone 1/trans-Rose ketone 1; Rose ketone 4 (Damascone); Rose ketone 3 (delta-Damascone)/trans-Rose ketone 3; cis-Rose ketone 2 (cis-beta-Damascone); trans-Rose ketone 2 (trans-beta-Damascone) is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 43052-87-5/ 23726-94-5/24720-09-0; 23696-85-7; 57378-68-4/ 71048-82-3; 23726-92-3; 23726-91-2 is the unique numerical identifier assigned to Alpha-Damascone/cis-Rose ketone 1/trans-Rose ketone 1; Rose ketone 4 (Damascone); Rose ketone 3 (delta-Damascone)/trans-Rose ketone 3; cis-Rose ketone 2 (cis-beta-Damascone); trans-Rose ketone 2 (trans-beta-Damascone) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of (b) 0.02% applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record Alpha-Damascone/cis-Rose ketone 1/trans-Rose ketone 1; Rose ketone 4 (Damascone); Rose ketone 3 (delta-Damascone)/trans-Rose ketone 3; cis-Rose ketone 2 (cis-beta-Damascone); trans-Rose ketone 2 (trans-beta-Damascone)

This page summarizes one Annex III record for Alpha-Damascone/cis-Rose ketone 1/trans-Rose ketone 1; Rose ketone 4 (Damascone); Rose ketone 3 (delta-Damascone)/trans-Rose ketone 3; cis-Rose ketone 2 (cis-beta-Damascone); trans-Rose ketone 2 (trans-beta-Damascone) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for Alpha-Damascone/cis-Rose ketone 1/trans-Rose ketone 1; Rose ketone 4 (Damascone); Rose ketone 3 (delta-Damascone)/trans-Rose ketone 3; cis-Rose ketone 2 (cis-beta-Damascone); trans-Rose ketone 2 (trans-beta-Damascone), but confirm any final regulatory decision against the current official annex wording and source files.

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