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InventoryRef 3163012/08/2020

ACID RED 52

Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt (CI 45100)

ACID RED 52 is linked to 2 EU annex records on this page. Inventory note: III/193 IV/71.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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MarketEvidence statusRecordsSource language
European UnionEvidence linked
Restricted entry found
Open this evidence		2English and EU languages
Great BritainEvidence linked
Restricted
Open this evidence		1English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandSource mapped
Official source mapped; ingredient rule not imported
0English
ASEANSource mapped
Official source mapped; ingredient rule not imported
0English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaSource mapped
Official source mapped; ingredient rule not imported
0Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 3520-42-1
CAS 3520-42-1PubChem CID 9916275

Acid Red 52

Lissamine rhodamine is an organic sodium salt having 4-[3,6-bis(diethylamino)xanthenium-9-yl]benzene-1,3-disulfonate as the counterion. It has a role as a fluorescent probe, a fluorochrome and a histological dye. It contains a lissamine rhodamine anion. — ChEBI

IUPAC name
sodium 4-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzene-1,3-disulfonate
Molecular formula
C27H29N2NaO7S2
Molecular weight
580.7 g/mol
Exact mass
580.13138790 Da
Topological polar surface area
147.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
8
Covalent units
2
Defined stereocentres
0

Also known as

C.I. Acid Red 52Acid Rhodamine BLissamine RhodamineKiton Rhodamine BXylene Red BAmido Rhodamine BAcid Red XBFood Red 106
16 more reported names
Fenazo Pink XXBSolar Rhodamine BAmacid Rhodamine BErio Acid Red XBErio Acid Red XBCRed No. 106Acid Leather Red KBAizen Food Red No. 106Pontacyl Brilliant PinkBrilliant Acid Rhodamine BCI 45100Red 106Brilliant Superlan Rhodamine BBrilliant Superlan Rhodamine 2B821LWZ3R6RVIBRACOLOR RED ARE52
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ACID RED 52

INCI name

ACID RED 52

Description

Hydrogen 3,6-bis(diethylamino)-9-(2,4-disulphonatophenyl)xanthylium, sodium salt (CI 45100)

Record provenance

Inventory reference
31630
Imported identity
ACID RED 52
Source update
12/08/2020
European Commission CosIng source notes
Annex III Restriction reference
Entry 193

ACID RED 52

CAS: 3520-42-1
EC: 222-529-8

Key data

CAS
3520-42-1
EC
222-529-8
Restriction
III/193 IV/71
Function
HAIR DYEING
Imparting color to hair. Hair dyeing preparations may be temporary, semi-permanent, or permanent, depending on the length of time the colorant remains on the hair.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#871 · ACID RED 52

Records sharing a CAS or EC identity

CI 45100

Ingredients with overlapping formulation functions

ACID RED 27 ALUMINUM LAKEHAIR DYEING
ACID RED 33HAIR DYEING
ACID RED 35HAIR DYEING
ACID RED 51COLORANT, HAIR DYEING
ACID RED 73HAIR DYEING
ACID RED 87COLORANT, HAIR DYEING
ACID RED 92HAIR DYEING
ACID RED 95HAIR DYEING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How ACID RED 52 appears in the CosIng inventory

The CosIng inventory lists ACID RED 52 as a cosmetic ingredient and this page links it to 2 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ACID RED 52 is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ACID RED 52 appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for ACID RED 52 reads: "III/193 IV/71". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, ACID RED 52 carries the following function designation(s):

CAS 3520-42-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for ACID RED 52

This page combines the CosIng inventory entry for ACID RED 52 with 2 linked Annex II–VI records from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research ACID RED 52 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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