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Annex III Entry 93 04/11/2010

DIAMINOPYRIMIDINE OXIDE

2,4-Pyrimidinediamine, 3-oxide

DIAMINOPYRIMIDINE OXIDE is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: 1.5%.

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Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: 1.5%
Entry: 93

Chemical identity and properties

PubChem 2D chemical structure for CAS 74638-76-9
CAS 74638-76-9PubChem CID 10197687

Aminexil

Diaminopyrimidine oxide is a compound similar to [minoxidil] which is used to aid in hair growth. — DrugBank

IUPAC name
3-hydroxy-2-iminopyrimidin-4-amine
Molecular formula
C4H6N4O
Molecular weight
126.12 g/mol
Exact mass
126.05416083 Da
XLogP3
-1.4
Topological polar surface area
85.7 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

RefChem:111997Kopexil2,4-diaminopyrimidine-3-oxide2,4-Diamino pyrimidine-3-oxideMexoryl SAG2,4-Pyrimidinediamine, 3-oxide2,6-diaminopyrimidine 1-oxide2,4-Diaminopyrimidine 3-N-oxide
10 more reported names
diaminopyrimidine oxideAC-137702,6-DIAMINOPYRIMIDIN-1-IUM-1-OLATEFT-0700705FT-0700707AMINEXIL [WHO-DD]2,4-Diaminopyrimidin-3-oxid2,4-Pyrimidinediamine 3-oxide6-Amino-2-iminopyrimidin-1(2H)-olBS-51568
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

1.5%

Product type

Hair products

INCI glossary name

DIAMINOPYRIMIDINE OXIDE

Chemical name

2,4-Pyrimidinediamine, 3-oxide

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
74638-76-9
EC
—
Annex
III
Entry number
93

Inventory links for DIAMINOPYRIMIDINE OXIDE

Direct matches are limited for this record, so nearby entries from Annex III are shown as well.

Annex III 3
Shared product type

OXALIC ACID

CAS: 144-62-7
EC: 205-634-3
Annex III 96
Nearby record in the same annex

MUSK XYLENE

CAS: 81-15-2
EC: 201-329-4
Annex III 97
Nearby record in the same annex

MUSK KETONE

CAS: 81-14-1
EC: 201-328-9

What Annex III means for DIAMINOPYRIMIDINE OXIDE

DIAMINOPYRIMIDINE OXIDE is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: 1.5%
  • Confirm product type compatibility: Hair products
  • Document conditions of use in the Product Information File (PIF).

Frequently asked questions

DIAMINOPYRIMIDINE OXIDE is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 74638-76-9 is the unique numerical identifier assigned to DIAMINOPYRIMIDINE OXIDE by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

The maximum concentration of 1.5% applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record DIAMINOPYRIMIDINE OXIDE

This page summarizes one Annex III record for DIAMINOPYRIMIDINE OXIDE from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for DIAMINOPYRIMIDINE OXIDE, but confirm any final regulatory decision against the current official annex wording and source files.

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