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Annex III Entry 70 Allergen 11/09/2023

Citral; Geranial; Neral

3,7-Dimethyl-2,6-octadienal; (E)-3,7-dimethylocta-2,6-dienal; (Z)-3,7-dimethylocta-2,6-dienal

Citral; Geranial; Neral is listed in Annex III and may only be used under the conditions shown in this record.

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Restricted substance— Annex III, EU Regulation 1223/2009
Entry: 70
Allergen
Declared fragrance allergen

This substance is on the EU list of fragrance allergens that must be named individually in the ingredient list, rather than being covered by the word "parfum", once it exceeds 0.001% in a leave-on product or 0.01% in a rinse-off product.

Declaration is a labelling duty under Article 19, not a restriction on use. See the allergen record

Chemical identity and properties

PubChem 2D chemical structure for CAS 106-26-3
CAS 106-26-3PubChem CID 643779

Neral

Neral is an enal that is 3,7-dimethyloctanal with unsaturation at positions C-2 and C-6. It has been isolated form the essential oils of plant species like lemon. It has a role as an apoptosis inducer and a plant metabolite. It is a monoterpenoid and an enal. — ChEBI

IUPAC name
(2Z)-3,7-dimethylocta-2,6-dienal
Molecular formula
C10H16O
Molecular weight
152.23 g/mol
Exact mass
152.120115130 Da
XLogP3
3.0
Topological polar surface area
17.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

cis-CitralCitral b(Z)-Citrallemonal2,6-Octadienal, 3,7-dimethyl-, (2Z)-8M466BQL1XCHEBI:29020RefChem:44035
16 more reported names
203-379-2(Z)-3,7-Dimethylocta-2,6-dienalbeta-Citral(Z)-NeralNeroli aldehyde2,6-Octadienal, 3,7-dimethyl-, (Z)-.beta.-CitralZ-Citral2,6-Octadienal,3,7-dimethyl-, (2Z)-cis-3,7-Dimethyl-2,6-octadienalcitral-b(Z)-3,7-Dimethyl-2,6-octadienalUNII-8M466BQL1X(Z)-alpha-citralEINECS 203-379-2cis-Citral (Neral)
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:29020

neral

An enal that is 3,7-dimethyloctanal with unsaturation at positions C-2 and C-6. It has been isolated form the essential oils of plant species like lemon.

Formula
C10H16O
Average mass
152.237 g/mol
Monoisotopic mass
152.12012 Da
Formal charge
0
  • enal — is a (CHEBI:51688)
  • monoterpenoid — is a (CHEBI:25409)
  • apoptosis inducer — has role (CHEBI:68495)
  • plant metabolite — has role (CHEBI:76924)
  • apoptosis inducer — has role (CHEBI:68495)
  • plant metabolite — has role (CHEBI:76924)
  • enal — is a (CHEBI:51688)
  • monoterpenoid — is a (CHEBI:25409)
Additional curated names
(2Z)-3,7-dimethylocta-2,6-dienalcis-citralcis-Citralcitral BLemonalNeral
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2019-06-18. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match643779

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (62.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P332+P317, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 294 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Precautionary Statement Codes: P261, P264, P272, P280, P302+P352, P321, P332+P317, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 141-27-5
CAS 141-27-5CAS 5392-40-5PubChem CID 638011

Citral

Geranial is a monoterpenoid that is (2E,6E)-octa-2,6-dienal substituted by methyl groups at positions 3 and 7. It has a role as a volatile oil component and a plant metabolite. It is a polyprenal, a monoterpenoid and an enal. — ChEBI

IUPAC name
(2E)-3,7-dimethylocta-2,6-dienal
Molecular formula
C10H16O
Molecular weight
152.23 g/mol
Exact mass
152.120115130 Da
XLogP3
3.0
Topological polar surface area
17.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

5392-40-5geranialdehydeLemsyn GB3,7-Dimethyl-2,6-octadienal2,6-Octadienal, 3,7-dimethyl-FEMA Number 2303NCI-C56348FEMA No. 2303
16 more reported names
3,7-Dimethyl-trans-2,6-octadienalNSC-6170T7EU0O9VPPCHEBI:23316RefChem:5692226-394-6GERANIALtrans-Citralalpha-Citral(E)-CitralCitral aGeranaldehydebeta-Geranial(E)-3,7-Dimethylocta-2,6-dienalgeranalGenanial
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Other restrictions

The presence of the substance or substances shall be indicated as ‘Citral’ in the list of ingredients referred to in Article 19(1), point (g), when the concentration of the substance or substances exceeds:
— 0,001 % in leave-on products
— 0,01 % in rinse-off products.

INCI glossary name

Citral; Geranial; Neral

Chemical name

3,7-Dimethyl-2,6-octadienal; (E)-3,7-dimethylocta-2,6-dienal; (Z)-3,7-dimethylocta-2,6-dienal

Chemical / IUPAC name

3,7-Dimethyl-2,6-octadienal

Regulatory information

Regulation

(EU) 2023/1545

See every entry this act set

Identified ingredients

EU Fragrance Allergen

This substance is linked to an EU fragrance-allergen reference. Check the current Annex III entry for the declaration threshold and any additional conditions.

CITRAL

Key data

CAS
5392-40-5; 141-27-5; 106-26-3
EC
226-394-6; 205-476-5; 203-379-2
Annex
III
Entry number
70

Inventory links for Citral; Geranial; Neral

Inventory Restriction reference
Ref 32857

CITRAL

CAS: 5392-40-5
EC: 226-394-6
Inventory Shared CAS number
Ref 41436

GERANIAL

CAS: 141-27-5
EC: 205-476-5
Inventory Shared CAS number
Ref 41460

NERAL

CAS: 106-26-3
EC: 203-379-2

Direct matches are limited for this record, so nearby entries from Annex III are shown as well.

Annex III 71
Nearby record in the same annex

Eugenol

CAS: 97-53-0
EC: 202-589-1
Annex III 67
Nearby record in the same annex

Amyl cinnamal

CAS: 122-40-7
EC: 204-541-5
Annex III 73
Nearby record in the same annex

ISOEUGENOL

CAS: 97-54-1; 5932-68-3; 5912-86-7
EC: 202-590-7; 227-678-2; 227-633-7
Annex III 76
Nearby record in the same annex

Cinnamal

CAS: 104-55-2
EC: 203-213-9

What Annex III means for Citral; Geranial; Neral

Citral; Geranial; Neral is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 3 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Document conditions of use in the Product Information File (PIF).
  • This substance is a regulated fragrance allergen. Declare it on the label by INCI name above 0.001% in leave-on or 0.01% in rinse-off products.

Frequently asked questions

Citral; Geranial; Neral is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 5392-40-5; 141-27-5; 106-26-3 is the unique numerical identifier assigned to Citral; Geranial; Neral by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Yes. Citral; Geranial; Neral is on the EU list of regulated fragrance allergens. It must be declared on the cosmetic product label by its INCI name when present above 0.001% in leave-on products or above 0.01% in rinse-off products, as required by EU Cosmetics Regulation 1223/2009.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record Citral; Geranial; Neral

This page summarizes one Annex III record for Citral; Geranial; Neral from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for Citral; Geranial; Neral, but confirm any final regulatory decision against the current official annex wording and source files.

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