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Annex III Entry 72 Allergen 14/05/2013

HYDROXYCITRONELLAL

Hydroxycitronellal

HYDROXYCITRONELLAL is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: (b) 1,0 %.

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Restricted substance— Annex III, EU Regulation 1223/2009
Max conc.: (b) 1,0 %
Entry: 72
Allergen
Declared fragrance allergen

This substance is on the EU list of fragrance allergens that must be named individually in the ingredient list, rather than being covered by the word "parfum", once it exceeds 0.001% in a leave-on product or 0.01% in a rinse-off product.

Declaration is a labelling duty under Article 19, not a restriction on use. See the allergen record

Chemical identity and properties

PubChem 2D chemical structure for CAS 107-75-5
CAS 107-75-5PubChem CID 7888

Hydroxycitronellal

Hydroxycitronellal is the tertiary alcohol arising from addition of water across the C=C double bond of citronellal. It has a role as a fragrance and an allergen. It is functionally related to a citronellal. — ChEBI

IUPAC name
7-hydroxy-3,7-dimethyloctanal
Molecular formula
C10H20O2
Molecular weight
172.26 g/mol
Exact mass
172.146329876 Da
XLogP3
1.6
Topological polar surface area
37.3 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

7-Hydroxycitronellal3,7-Dimethyl-7-hydroxyoctanalCitronellal hydratePhixiaCyclaliaCyclosiaLaurineFixol
16 more reported names
Lilyl aldehydeMuguettine principleOctanal, 7-hydroxy-3,7-dimethyl-Musuettine principleOxydihydrocitronellalhydroxy citronellal1-OCTANAL, 3,7-DIMETHYL-7-HYDROXY-FEMA No. 25838SQ0VA4YURCHEBI:534593,7-dimethyl-7-hydroxyoctan-1-alNSC-406740MuguetMusuetRefChem:147154203-518-7
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:53459

hydroxycitronellal

The tertiary alcohol arising from addition of water across the C=C double bond of citronellal.

Formula
C10H20O2
Average mass
172.268 g/mol
Monoisotopic mass
172.14633 Da
Formal charge
0
  • tertiary alcohol — is a (CHEBI:26878)
  • allergen — has role (CHEBI:50904)
  • fragrance — has role (CHEBI:48318)
  • citronellal — has functional parent (CHEBI:47856)
  • allergen — has role (CHEBI:50904)
  • fragrance — has role (CHEBI:48318)
  • tertiary alcohol — is a (CHEBI:26878)
Additional curated names
7-hydroxy-3,7-dimethyloctanal3,7-dimethyl-7-hydroxyoctan-1-al3,7-Dimethyl-7-hydroxyoctanal7-hydroxycitronellalCitronellal hydratehydroxy citronellal
Cross-references from this source
  • CAS: 107-75-5 — ChemIDplus
  • CAS: 107-75-5 — NIST Chemistry WebBook
  • REGISTRY_NUMBER: 1721290 — Reaxys
  • MANUAL_X_REF: HMDB0031739 — HMDB

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2014-05-12. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7888

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for < 0.1% (1 of 2046) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H317 (> 99.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (> 99.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2046 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 2046 reports by companies.; There are 9 notifications provided by 2045 of 2046 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P261, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Precautionary Statement Codes: P261, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

(b) 1,0 %

Product type

Oral products Other products

Other restrictions

(a) (b) The presence of the substance must be indicated in the list of ingredients referred to in Article 19(1)(g) when its concentration exceeds: — 0,001 % in leave-on products — 0,01 % in rinse-off products

INCI glossary name

HYDROXYCITRONELLAL

Chemical name

Hydroxycitronellal

Chemical / IUPAC name

7-Hydroxycitronellal

Regulatory information

Regulation

(EC) 2013/344

See every entry this act set

SCCS opinions

Identified ingredients

EU Fragrance Allergen

This substance is linked to an EU fragrance-allergen reference. Check the current Annex III entry for the declaration threshold and any additional conditions.

HYDROXYCITRONELLAL

Key data

CAS
107-75-5
EC
203-518-7
Annex
III
Entry number
72

Inventory links for HYDROXYCITRONELLAL

What Annex III means for HYDROXYCITRONELLAL

HYDROXYCITRONELLAL is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.

When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Ensure formulation concentration does not exceed: (b) 1,0 %
  • Confirm product type compatibility: (a) Oral products (b) Other products
  • Document conditions of use in the Product Information File (PIF).
  • This substance is a regulated fragrance allergen. Declare it on the label by INCI name above 0.001% in leave-on or 0.01% in rinse-off products.

Frequently asked questions

HYDROXYCITRONELLAL is listed in Annex III of EU Regulation 1223/2009 as a restricted substance. It may only be used under the conditions specified in the entry, including any maximum concentration, product type limitation and required warning statements shown above.

CAS 107-75-5 is the unique numerical identifier assigned to HYDROXYCITRONELLAL by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Yes. HYDROXYCITRONELLAL is on the EU list of regulated fragrance allergens. It must be declared on the cosmetic product label by its INCI name when present above 0.001% in leave-on products or above 0.01% in rinse-off products, as required by EU Cosmetics Regulation 1223/2009.

The maximum concentration of (b) 1,0 % applies to the concentration of the substance in the ready-to-use cosmetic product. When the substance is supplied as part of a blend or mixture, the calculation must account for the contribution of all sources in the formulation. The combined concentration must not exceed the stated limit.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex III record HYDROXYCITRONELLAL

This page summarizes one Annex III record for HYDROXYCITRONELLAL from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex III conditions for HYDROXYCITRONELLAL, but confirm any final regulatory decision against the current official annex wording and source files.

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