Beta- Caryophyllene
(1R,4E,9S)-4,11,11-- Trimethyl- 8-methylenebicyclo [7.2.0]undec- 4-ene
Beta- Caryophyllene is listed in Annex III and may only be used under the conditions shown in this record.
Chemical identity and properties
(-)-Caryophyllene
(-)-beta-caryophyllene is a beta-caryophyllene in which the stereocentre adjacent to the exocyclic double bond has S configuration while the remaining stereocentre has R configuration. It is the most commonly occurring form of beta-caryophyllene, occurring in many essential oils, particularly oil of cloves. It has a role as an insect attractant, a metabolite, a non-steroidal anti-inflammatory drug and a fragrance. It is an enantiomer of a (+)-beta-caryophyllene. — ChEBI
- IUPAC name
- (1R,4E,9S)-4,11,11-trimethyl-8-methylidenebicyclo[7.2.0]undec-4-ene
- Molecular formula
- C15H24
- Molecular weight
- 204.35 g/mol
- Exact mass
- 204.187800766 Da
- XLogP3
- 4.4
- Topological polar surface area
- 0.0 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 0
- Covalent units
- 1
- Defined stereocentres
- 2
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:10357
- ChEMBL:CHEMBL445740
- EPA DTXSID:DTXSID8024739
- PubMed:30096653
- PubMed:22945026
- PubMed:21356367
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Other restrictions
The presence of the substance shall be indicated in the list of ingredients referred to in Article 19(1), point (g), when its concentration exceeds: — 0,001 % in leave-on products — 0,01 % in rinse-off products.
INCI glossary name
Beta- Caryophyllene
Chemical name
(1R,4E,9S)-4,11,11-- Trimethyl- 8-methylenebicyclo [7.2.0]undec- 4-ene
Regulatory information
Identified ingredients
Key data
Inventory links for Beta- Caryophyllene
Related records for Beta- Caryophyllene
Direct matches are limited for this record, so nearby entries from Annex III are shown as well.
Camphor
Carvone
Anethole
Menthol
What Annex III means for Beta- Caryophyllene
Beta- Caryophyllene is a restricted substance under Annex III of EU Cosmetics Regulation 1223/2009. Its use in cosmetics is only permitted under the specific conditions set out in the entry above, including applicable concentration limits, product type restrictions and required warning statements.
When including this substance in a formulation, all conditions — maximum concentration, product scope and warning labels — must be met simultaneously. Compliance with one condition does not override the others.
This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Document conditions of use in the Product Information File (PIF).
Frequently asked questions
Source note for Annex III record Beta- Caryophyllene
This page summarizes one Annex III record for Beta- Caryophyllene from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex III conditions for Beta- Caryophyllene, but confirm any final regulatory decision against the current official annex wording and source files.
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