Why does CAS 87-44-5 appear in more than one EU cosmetic annex?

A substance identified by CAS 87-44-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 87-44-5?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 87-44-5 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 87-44-5

Q: How do I use CAS 87-44-5 for compliance screening?

Cross-reference CAS 87-44-5 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 87-44-5 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 87-44-5

CAS 87-44-5PubChem CID 5281515

(-)-Caryophyllene

(-)-beta-caryophyllene is a beta-caryophyllene in which the stereocentre adjacent to the exocyclic double bond has S configuration while the remaining stereocentre has R configuration. It is the most commonly occurring form of beta-caryophyllene, occurring in many essential oils, particularly oil of cloves. It has a role as an insect attractant, a metabolite, a non-steroidal anti-inflammatory drug and a fragrance. It is an enantiomer of a (+)-beta-caryophyllene. — ChEBI

IUPAC name: (1R,4E,9S)-4,11,11-trimethyl-8-methylidenebicyclo[7.2.0]undec-4-ene

Molecular formula: C15H24
Molecular weight: 204.35 g/mol
Exact mass: 204.187800766 Da
XLogP3: 4.4
Topological polar surface area: 0.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 0
Covalent units: 1
Defined stereocentres: 2

Also known as

BETA-CARYOPHYLLENECaryophyllene(-)-trans-CaryophylleneL-Caryophyllenetrans-beta-caryophyllenebeta-CaryophyllenFEMA No. 2252(-)-E-Caryophyllene

16 more reported names

NSC-11906BHW853AU9H8-Methylene-4,11,11-(trimethyl)bicyclo(7.2.0)undec-4-eneBicyclo(7.2.0)undec-4-ene, 8-methylene-4,11,11-trimethyl-, (E)-(1R,9S)-(-)-CHEBI:631918-Methylene-4,11,11-(trimethyl)bicyclo[7.2.0]undec-4-ene(1R,4E,9S)-4,11,11-trimethyl-8-methylidenebicyclo(7.2.0)undec-4-eneBicyclo(7.2.0)undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R,4E,9S)-Bicyclo[7.2.0]undec-4-ene, 8-methylene-4,11,11-trimethyl-, (E)-(1R,9S)-(-)-RefChem:6628(1R,9S)-4,11,11-trimethyl-8-methylidenebicyclo(7.2.0)undec-4-ene201-746-1trans-Caryophyllene(-)-beta-caryophyllene(E)-Caryophyllene(E)-beta-caryophyllene

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:10357
ChEMBL:CHEMBL445740
EPA DTXSID:DTXSID8024739
PubMed:30096653
PubMed:22945026
PubMed:21356367

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 87-44-5

1 total

Annex

III

Entry

332

Beta- Caryophyllene

(1R,4E,9S)-4,11,11-- Trimethyl- 8-methylenebicyclo [7.2.0]undec- 4-ene

The presence of the substance shall be indicated in the list of ingredients referred to in Article 19(1), point (g), when its concentration exceeds: — 0,001 % in leave-on products — 0,01 % in rinse-off products.

201-746-1

How CAS 87-44-5 is used on this site

CAS 87-44-5 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 87-44-5 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 87-44-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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