What is CAS 111-76-2 for BUTOXYETHANOL?

CAS 111-76-2 is the unique numerical identifier assigned to BUTOXYETHANOL by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

How is the maximum concentration of BUTOXYETHANOL calculated in a finished product?

The maximum concentration of a) 4.0% b) 2.0% applies to the substance in the ready-to-use cosmetic product. When supplied as part of a blend or mixture, the calculation must account for contributions from all sources in the formulation.

Annex III Entry 188 24/05/2013

BUTOXYETHANOL

Q: How do I check if my product formula contains BUTOXYETHANOL?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

Ethylene glycol monobutyl ether (EGBE)

BUTOXYETHANOL is listed in Annex III and may only be used under the conditions shown in this record. Maximum concentration in this record: a) 4.0% b) 2.0%.

Restricted substance— Annex III, EU Regulation 1223/2009

Max conc.: a) 4.0% b) 2.0%

Entry: 188

Chemical identity and properties

PubChem 2D chemical structure for CAS 111-76-2

CAS 111-76-2PubChem CID 8133

2-Butoxyethanol

2-butoxyethanol is a primary alcohol that is ethanol in which one of the methyl hydrogens is replaced by a butoxy group. A high-boiling (171C) colourless liquid, it is used as a solvent for paints and inks, as well as in some dry cleaning solutions. It has a role as a protic solvent. It is a primary alcohol and a glycol ether. — ChEBI

IUPAC name: 2-butoxyethanol

Molecular formula: C6H14O2
Molecular weight: 118.17 g/mol
Exact mass: 118.099379685 Da
XLogP3: 0.8
Topological polar surface area: 29.5 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

Butyl glycolButyl cellosolveButoxyethanolETHYLENE GLYCOL MONOBUTYL ETHEREthylene glycol butyl ethern-ButoxyethanolButyl oxitolDowanol EB

16 more reported names

Glycol butyl etherEthanol, 2-butoxy-3-Oxa-1-heptanolGafcol EBJeffersol ebGlycol ether ebEktasolve EBO-Butyl ethylene glycolBUCSChimec NR2-Butoxy-1-ethanol2-n-ButoxyethanolButyl cellu-solEGBEGlycol monobutyl ether2-Butoxy ethanol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:63921
ChEMBL:CHEMBL284588
EPA DTXSID:DTXSID1024097
PubMed:32979392
PubMed:29556671
PubMed:22959174
PubMed:22898986
PubMed:22804997
PubMed:22649449
PubMed:22580533
PubMed:22563443
PubMed:22479475
PubMed:22448341
PubMed:22330932
PubMed:22315560

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match8133

Attributed physical-property, hazard, environmental and use annotations.

Autoignition Temperature: 472 °F (USCG, 1999) Source: CAMEO Chemicals
Autoignition Temperature: 238 °C (460 °F) Source: Hazardous Substances Data Bank (HSDB)
Autoignition Temperature: 238 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Boiling Point: 340 °F at 743 mmHg (NTP, 1992) Source: CAMEO Chemicals
Boiling Point: 168.4 °C Source: Hazardous Substances Data Bank (HSDB)
Boiling Point: 168.40 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
Boiling Point: 171 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Boiling Point: 339 °F Source: Occupational Safety and Health Administration (OSHA)
Boiling Point: 168.4 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
Boiling Point: 339 °F Source: The National Institute for Occupational Safety and Health (NIOSH)

Color/Form: Colorless liquid Source: Hazardous Substances Data Bank (HSDB)

Density: 0.902 at 68 °F (USCG, 1999) - Less dense than water; will float Source: CAMEO Chemicals
Density: 0.9015 at 20 °C Source: Hazardous Substances Data Bank (HSDB)
Density: Relative density (water = 1): 0.90 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Density: 0.9 Source: Occupational Safety and Health Administration (OSHA)
Density: 0.9012 @ 20°C Source: PAC Chemical Database, U.S. Department of Energy
Density: 0.90 Source: The National Institute for Occupational Safety and Health (NIOSH)

Flash Point: 141 °F (NTP, 1992) Source: CAMEO Chemicals
Flash Point: 62 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Flash Point: 143 °F (62 °C) (Closed Cup) Source: Hazardous Substances Data Bank (HSDB)
Flash Point: 60 °C c.c. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Flash Point: 143 °F Source: Occupational Safety and Health Administration (OSHA)
Flash Point: 143 °F Source: The National Institute for Occupational Safety and Health (NIOSH)

LogP: log Kow = 0.83 Source: Hazardous Substances Data Bank (HSDB)
LogP: 0.83 Source: Human Metabolome Database (HMDB)
LogP: 0.830 Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Melting Point: -94 °F (NTP, 1992) Source: CAMEO Chemicals
Melting Point: -74.8 °C Source: Hazardous Substances Data Bank (HSDB)
Melting Point: -74.8 °C Source: Human Metabolome Database (HMDB)
Melting Point: -75 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Melting Point: -107 °F Source: Occupational Safety and Health Administration (OSHA)
Melting Point: -74.8 °C Source: PAC Chemical Database, U.S. Department of Energy
Melting Point: -107 °F Source: The National Institute for Occupational Safety and Health (NIOSH)

Odor: Mild, ether-like odor Source: Hazardous Substances Data Bank (HSDB)
Odor: Slight, rancid odor Source: Hazardous Substances Data Bank (HSDB)
Odor: Weak, pleasant odor Source: Hazardous Substances Data Bank (HSDB)
Odor: Characteristic; quality: sweet, ester; hedonic tone: pleasant Source: Hazardous Substances Data Bank (HSDB)

Physical Description: Ethylene glycol monobutyl ether appears as a colorless liquid with a mild, pleasant odor. Less dense than water. Flash point 160 °F. Irritates skin and eyes and may be toxic by ingestion. Used as a solvent and to make paints and varnish. Source: CAMEO Chemicals
Physical Description: Large Crystals; CBI; Gas Vapor; Liquid; Liquid; Liquid; Other Solid Source: EPA Chemical Data Reporting (CDR)
Physical Description: Colorless liquid with a mild, ether-like odor; [NIOSH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Physical Description: Liquid Source: Human Metabolome Database (HMDB)
Physical Description: COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Physical Description: Colorless liquid with a mild, ether-like odor. Source: Occupational Safety and Health Administration (OSHA)
Physical Description: Colorless liquid with a mild, ether-like odor. Source: The National Institute for Occupational Safety and Health (NIOSH)

Refractive Index: Index of refraction: 1.4198 at 20 °C/D Source: Hazardous Substances Data Bank (HSDB)

Solubility: greater than or equal to 100 mg/mL at 72 °F (NTP, 1992) Source: CAMEO Chemicals
Solubility: Miscible with water Source: Hazardous Substances Data Bank (HSDB)
Solubility: Soluble in ethyl alcohol, ethyl ether; slightly soluble in carbon tetrachloride Source: Hazardous Substances Data Bank (HSDB)
Solubility: Soluble in mineral oil, most organic solvents. Source: Hazardous Substances Data Bank (HSDB)
Solubility: Mixes in all proportions with acetone, benzene, carbon tetrachloride, ethyl ether, n-heptane and water; miscible in all proportions with many ketones, ethers, alcohols, aromatic paraffin and halogenated hydrocarbons. Source: Hazardous Substances Data Bank (HSDB)
Solubility: 1000 mg/mL at 20 °C Source: Human Metabolome Database (HMDB)
Solubility: Solubility in water: miscible Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Solubility: Miscible Source: The National Institute for Occupational Safety and Health (NIOSH)

Vapor Pressure: 0.76 mmHg at 68 °F ; 0.88 mmHg at 77 °F; 300 mmHg at 284 °F (NTP, 1992) Source: CAMEO Chemicals
Vapor Pressure: 0.88 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Vapor Pressure: Vapor pressure = 0.6 mm Hg at 20 °C (0.89 hPa); 3.7 hPa at 40 °C; Conversions: 1 mg/cu m = 0.204 ppm; 1 ppm = 4.90 mg/cu m Source: Hazardous Substances Data Bank (HSDB)
Vapor Pressure: Vapor pressure: -31 °C at 1 Pa; -8 °C at 10 Pa; 20 °C at 100 Pa; 55 °C at 1 kPa; 103.2 °C at 10kPa; 170.2 °C at kPa Source: Hazardous Substances Data Bank (HSDB)
Vapor Pressure: 0.88 mm Hg at 25 °C Source: Hazardous Substances Data Bank (HSDB)
Vapor Pressure: Vapor pressure, kPa at 20 °C: 0.10 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Vapor Pressure: 0.8 mmHg Source: Occupational Safety and Health Administration (OSHA)
Vapor Pressure: 0.8 [mm Hg] @25 °C Source: PAC Chemical Database, U.S. Department of Energy
Vapor Pressure: 0.8 mmHg Source: The National Institute for Occupational Safety and Health (NIOSH)

Viscosity: 3.15 centistokes at 25 °C Source: Hazardous Substances Data Bank (HSDB)

IARC Carcinogenic Agent: 2-Butoxyethanol Source: International Agency for Research on Cancer (IARC)
IARC Carcinogenic Classes: Group 3: Not classifiable as to its carcinogenicity to humans Source: International Agency for Research on Cancer (IARC)
IARC Monographs: Volume 88: (2006) Formaldehyde, 2-Butoxyethanol and 1-tert-Butoxypropan-2-ol Source: International Agency for Research on Cancer (IARC)
Publication Year: 2006 Source: International Agency for Research on Cancer (IARC)
Evaluation Year: 2004 Source: International Agency for Research on Cancer (IARC)
Substance: 2-Butoxyethanol (Ethylene Glycol Monobutyl Ether) Source: NTP Technical Reports
NTP Technical Report: TR-484: Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) (2000 ) Source: NTP Technical Reports
Peer Review Date: 10/30/98 Source: NTP Technical Reports
Conclusion for Male Rat: No Evidence Source: NTP Technical Reports
Conclusion for Female Rat: Equivocal Evidence Source: NTP Technical Reports
Conclusion for Male Mice: Some Evidence Source: NTP Technical Reports
Conclusion for Female Mice: Some Evidence Source: NTP Technical Reports

Exposure Routes: The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Source: The National Institute for Occupational Safety and Health (NIOSH)

First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)

Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Note: This chemical does not meet GHS hazard criteria for 0.4% (13 of 3076) of reports. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (99.5%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (79.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H315 (99.6%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (99.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331 (11.7%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H332 (83.6%): Harmful if inhaled [Warning Acute toxicity, inhalation] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 3076 reports by companies from 31 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 13 of 3076 reports by companies.; There are 30 notifications provided by 3063 of 3076 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Note: This chemical does not meet GHS hazard criteria for 12.7% (87 of 686) of reports. Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (12.4%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (11.1%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H318 (38.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H319 (37.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P305+P354+P338, P317, P321, P330, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 686 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 87 of 686 reports by companies.; There are 8 notifications provided by 599 of 686 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)

Target Organs: Hematologic Source: EPA Integrated Risk Information System (IRIS)
Target Organs: Eyes, skin, respiratory system, central nervous system, hematopoietic system, blood, kidneys, liver, lymphoid system Source: The National Institute for Occupational Safety and Health (NIOSH)

Cosmetic Ingredient Review Conclusion: On the basis of the animal and clinical data included in this report, the Expert Panel concludes that Butoxyethanol is safe in hair and nail products at concentrations up to 10.0%. Note: In 2002, the CIR Expert Panel considered available new data on this ingredient and reaffirmed the above conclusion. Source: Cosmetic Ingredient Review (CIR)
Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)
Toxicity Summary: 2-Butoxyethanol is a high production volume glycol ether. It is a colorless liquid that is miscible in water and soluble in most organic solvents. 2-Butoxyethanol is used widely as a solvent in surface coatings, such as spray lacquers, quick dry lacquers, enamels, varnishes, varnish removers and latex paint. Based on limited data, ambient exposures in air are generally in the ug/cu m range. Industrial exposure of the general population to this chemical is most likely from inhalation and dermal absorption during the use of products containing 2-butoxyethanol. Levels of airborne 2-butoxyethanol in occupational settings are typically in the mg/cu m range. The results of in vitro studies indicate that human red blood cells are not as sensitive to the hemolytic effects of 2-butoxyethanol and 2-butoxyacetic acid and also that red blood cells are more sensitive to hemolysis by 2-butoxyacetic acid than to hemolysis by 2-butoxyethanol. 2-Butoxyethanol is readily absorbed following inhalation, oral or dermal exposure. The chemical is metabolized via alcohol and aldehyde dehydrogenases, with the formation of 2-butoxyacetaldehyde and 2-butoxyacetic acid, the principal metabolite, although othe Source: Hazardous Substances Data Bank (HSDB)

Environmental Bioconcentration: An estimated BCF of 3 was calculated for ethylene glycol mono-n-butyl ether(SRC), using an estimated log Kow of 0.83(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low (SRC). Source: Hazardous Substances Data Bank (HSDB)

Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 8(SRC), determined from a log Kow of 0.83(2), indicates that ethylene glycol mono-n-butyl ether is expected to have very high mobility in soil(SRC). Volatilization of ethylene glycol mono-n-butyl ether from moist soil surfaces is expected to be an important fate process(SRC) given an Henry's Law constant of 1.60X10-6 atm-cu m/mole(3). Ethylene glycol mono-n-butyl ether is expected to volatilize slowly from dry soil surfaces(SRC) based upon a vapor pressure of 0.88 mm Hg(4). Ethylene glycol mono-n-butyl ether reached 96% of its theoretical BOD in 14 days using an activated sludge inoculum(5). Therefore this compound is expected to biodegrade rapidly in the soil environment. Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 8(SRC), determined from a log Kow of 0.83(2), indicates that ethylene glycol mono-n-butyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 1.6X10-6 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 17 and 185 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3, from its log Kow of 0.83(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Alcohols and ethers are generally resistant to hydrolysis(7). Ethylene glycol mono-n-butyl ether reached 96% of its Theoretical BOD in 14 days using an activated sludge inoculum(8). Therefore this compound is expected to biodegrade rapidly in the aquatic environment. Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylene glycol mono-n-butyl ether, which has a vapor pressure of 0.88 mm Hg at 25 °C(2) is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethylene glycol mono-n-butyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 15 hours(SRC), calculated from its rate constant of 1.86X10-11 cu cm/molecule-sec at 25 °C(3). Ethylene glycol mono-n-butyl ether does not contain chromophores that absorb at wavelengths >290 nm(4), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Consumer Uses: Insulators; Dispersing agent; Solvent; Other; Surfactant (surface active agent); Monomers; Processing aids not otherwise specified; Cleaning agent; Viscosity modifiers; Not Known or Reasonably Ascertainable; Corrosion inhibitor; Catalyst; Film former; Intermediate; Etching agent; Propellants, non-motive (blowing agents) Source: EPA Chemical Data Reporting (CDR)

Industry Uses: Intermediate; Etching agent; Adhesion/cohesion promoter; Chelating agent; Demulsifier; Surface modifier; Cleaning agent; Hydraulic fluids; Viscosity modifiers; Catalyst; Waterproofing agent; Not Known or Reasonably Ascertainable; Diluent; Surfactant (surface active agent); Monomers; Processing aids not otherwise specified; Fuel agents; Plating agent; Anti-freeze agent; Solvent; Dispersing agent; Lubricating agent; Other Source: EPA Chemical Data Reporting (CDR)

Cosmetic Ingredient Review Link: CIR ingredient: Butoxyethanol Source: Cosmetic Ingredient Review (CIR)
Sources/Uses: Used as solvent in surface coatings; [ACGIH] Also used in hydraulic fluids, glass cleaners, and leather cleaners; [Sullivan, p. 1203] Used as a solvent in paints, coatings, inks, metal cleaners, and household cleaners; Occupational exposures are high in silk screen printing; [Reference #2] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Industrial Processes with risk of exposure: Semiconductor Manufacturing [Category: Industry]; Painting (Solvents) [Category: Paint]; Dry Cleaning [Category: Clean]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry]; Silk-Screen Printing [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Activities with risk of exposure: Intalagio printing [Category: Hobbies] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: Both oil base and water base fracturing fluids are being used in the fracturing industry. Water base, which includes alcohol-water mixtures and low strength acids, make up the majority of treating fluids. The common chemicals added to these fluids are polymers for viscosity development, crosslinkers for viscosity enhancement, pH control chemicals, gel breakers for polymer degradation following the treatment, surfactants, clay stabilizers, alcohol, bactericides, fluid loss additives and friction reducer. /Hydraulic fracturing/ Source: Hazardous Substances Data Bank (HSDB)
Uses: Hydraulic fracturing uses a specially blended liquid which is pumped into a well under extreme pressure causing cracks in rock formations underground. These cracks in the rock then allow oil and natural gas to flow, increasing resource production. ... Chemical Name: 2-Butoxyethanol; Chemical Purpose: Product stabilizer; Product Function: surfactant. Source: Hazardous Substances Data Bank (HSDB)
Uses: For ethylene glycol monobutyl ether (USEPA/OPP Pesticide Code: 011501) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
Uses: In hydraulic fluids Source: Hazardous Substances Data Bank (HSDB)
Uses: For more Uses (Complete) data for ETHYLENE GLYCOL MONO-N-BUTYL ETHER (11 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Maximum concentration

a) 4.0% b) 2.0%

Product type

Solvent in oxidative hair dye products Solvent in non-oxidative hair dye products

Other restrictions

(a) (b) No use in aerosol dispensers (sprays)

INCI glossary name

BUTOXYETHANOL

Chemical name

Ethylene glycol monobutyl ether (EGBE)

Regulatory information

Regulation

(EC) 2013/344

See every entry this act set

SCCS opinions

Opinion on Ethylene Glycol Monobutyl Ether (EGBE) - Butoxyethanol (INCI)

Identified ingredients

BUTOXYETHANOL

Key data

CAS

111-76-2

203-905-0

Annex

III

Entry number

188

Inventory links for BUTOXYETHANOL

Inventory Restriction reference

Ref 31696

BUTOXYETHANOL

CAS: 111-76-2

EC: 203-905-0

Direct matches are limited for this record, so nearby entries from Annex III are shown as well.

Annex III 187