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CAS 1 record

CAS 111-76-2

CAS 111-76-2 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 111-76-2
CAS 111-76-2PubChem CID 8133

2-Butoxyethanol

2-butoxyethanol is a primary alcohol that is ethanol in which one of the methyl hydrogens is replaced by a butoxy group. A high-boiling (171C) colourless liquid, it is used as a solvent for paints and inks, as well as in some dry cleaning solutions. It has a role as a protic solvent. It is a primary alcohol and a glycol ether. — ChEBI

IUPAC name
2-butoxyethanol
Molecular formula
C6H14O2
Molecular weight
118.17 g/mol
Exact mass
118.099379685 Da
XLogP3
0.8
Topological polar surface area
29.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

Butyl glycolButyl cellosolveButoxyethanolETHYLENE GLYCOL MONOBUTYL ETHEREthylene glycol butyl ethern-ButoxyethanolButyl oxitolDowanol EB
16 more reported names
Glycol butyl etherEthanol, 2-butoxy-3-Oxa-1-heptanolGafcol EBJeffersol ebGlycol ether ebEktasolve EBO-Butyl ethylene glycolBUCSChimec NR2-Butoxy-1-ethanol2-n-ButoxyethanolButyl cellu-solEGBEGlycol monobutyl ether2-Butoxy ethanol
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8133

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for 0.4% (13 of 3076) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (99.5%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (79.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H315 (99.6%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (99.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331 (11.7%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H332 (83.6%): Harmful if inhaled [Warning Acute toxicity, inhalation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 3076 reports by companies from 31 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 13 of 3076 reports by companies.; There are 30 notifications provided by 3063 of 3076 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Note: This chemical does not meet GHS hazard criteria for 12.7% (87 of 686) of reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (12.4%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (11.1%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H318 (38.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H319 (37.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P305+P354+P338, P317, P321, P330, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 686 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 87 of 686 reports by companies.; There are 8 notifications provided by 599 of 686 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Conclusion: On the basis of the animal and clinical data included in this report, the Expert Panel concludes that Butoxyethanol is safe in hair and nail products at concentrations up to 10.0%. Note: In 2002, the CIR Expert Panel considered available new data on this ingredient and reaffirmed the above conclusion. Source: Cosmetic Ingredient Review (CIR)
  • Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: 2-Butoxyethanol is a high production volume glycol ether. It is a colorless liquid that is miscible in water and soluble in most organic solvents. 2-Butoxyethanol is used widely as a solvent in surface coatings, such as spray lacquers, quick dry lacquers, enamels, varnishes, varnish removers and latex paint. Based on limited data, ambient exposures in air are generally in the ug/cu m range. Industrial exposure of the general population to this chemical is most likely from inhalation and dermal absorption during the use of products containing 2-butoxyethanol. Levels of airborne 2-butoxyethanol in occupational settings are typically in the mg/cu m range. The results of in vitro studies indicate that human red blood cells are not as sensitive to the hemolytic effects of 2-butoxyethanol and 2-butoxyacetic acid and also that red blood cells are more sensitive to hemolysis by 2-butoxyacetic acid than to hemolysis by 2-butoxyethanol. 2-Butoxyethanol is readily absorbed following inhalation, oral or dermal exposure. The chemical is metabolized via alcohol and aldehyde dehydrogenases, with the formation of 2-butoxyacetaldehyde and 2-butoxyacetic acid, the principal metabolite, although othe Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated for ethylene glycol mono-n-butyl ether(SRC), using an estimated log Kow of 0.83(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low (SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 8(SRC), determined from a log Kow of 0.83(2), indicates that ethylene glycol mono-n-butyl ether is expected to have very high mobility in soil(SRC). Volatilization of ethylene glycol mono-n-butyl ether from moist soil surfaces is expected to be an important fate process(SRC) given an Henry's Law constant of 1.60X10-6 atm-cu m/mole(3). Ethylene glycol mono-n-butyl ether is expected to volatilize slowly from dry soil surfaces(SRC) based upon a vapor pressure of 0.88 mm Hg(4). Ethylene glycol mono-n-butyl ether reached 96% of its theoretical BOD in 14 days using an activated sludge inoculum(5). Therefore this compound is expected to biodegrade rapidly in the soil environment. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 8(SRC), determined from a log Kow of 0.83(2), indicates that ethylene glycol mono-n-butyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 1.6X10-6 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 17 and 185 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3, from its log Kow of 0.83(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Alcohols and ethers are generally resistant to hydrolysis(7). Ethylene glycol mono-n-butyl ether reached 96% of its Theoretical BOD in 14 days using an activated sludge inoculum(8). Therefore this compound is expected to biodegrade rapidly in the aquatic environment. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylene glycol mono-n-butyl ether, which has a vapor pressure of 0.88 mm Hg at 25 °C(2) is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethylene glycol mono-n-butyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 15 hours(SRC), calculated from its rate constant of 1.86X10-11 cu cm/molecule-sec at 25 °C(3). Ethylene glycol mono-n-butyl ether does not contain chromophores that absorb at wavelengths >290 nm(4), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Insulators; Dispersing agent; Solvent; Other; Surfactant (surface active agent); Monomers; Processing aids not otherwise specified; Cleaning agent; Viscosity modifiers; Not Known or Reasonably Ascertainable; Corrosion inhibitor; Catalyst; Film former; Intermediate; Etching agent; Propellants, non-motive (blowing agents) Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Intermediate; Etching agent; Adhesion/cohesion promoter; Chelating agent; Demulsifier; Surface modifier; Cleaning agent; Hydraulic fluids; Viscosity modifiers; Catalyst; Waterproofing agent; Not Known or Reasonably Ascertainable; Diluent; Surfactant (surface active agent); Monomers; Processing aids not otherwise specified; Fuel agents; Plating agent; Anti-freeze agent; Solvent; Dispersing agent; Lubricating agent; Other Source: EPA Chemical Data Reporting (CDR)
  • Cosmetic Ingredient Review Link: CIR ingredient: Butoxyethanol Source: Cosmetic Ingredient Review (CIR)
  • Sources/Uses: Used as solvent in surface coatings; [ACGIH] Also used in hydraulic fluids, glass cleaners, and leather cleaners; [Sullivan, p. 1203] Used as a solvent in paints, coatings, inks, metal cleaners, and household cleaners; Occupational exposures are high in silk screen printing; [Reference #2] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Semiconductor Manufacturing [Category: Industry]; Painting (Solvents) [Category: Paint]; Dry Cleaning [Category: Clean]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry]; Silk-Screen Printing [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Activities with risk of exposure: Intalagio printing [Category: Hobbies] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Both oil base and water base fracturing fluids are being used in the fracturing industry. Water base, which includes alcohol-water mixtures and low strength acids, make up the majority of treating fluids. The common chemicals added to these fluids are polymers for viscosity development, crosslinkers for viscosity enhancement, pH control chemicals, gel breakers for polymer degradation following the treatment, surfactants, clay stabilizers, alcohol, bactericides, fluid loss additives and friction reducer. /Hydraulic fracturing/ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Hydraulic fracturing uses a specially blended liquid which is pumped into a well under extreme pressure causing cracks in rock formations underground. These cracks in the rock then allow oil and natural gas to flow, increasing resource production. ... Chemical Name: 2-Butoxyethanol; Chemical Purpose: Product stabilizer; Product Function: surfactant. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For ethylene glycol monobutyl ether (USEPA/OPP Pesticide Code: 011501) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: In hydraulic fluids Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for ETHYLENE GLYCOL MONO-N-BUTYL ETHER (11 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 111-76-2

1 total
Annex
III
Entry
188

BUTOXYETHANOL

Ethylene glycol monobutyl ether (EGBE)

(a) (b) No use in aerosol dispensers (sprays)

EC
203-905-0
Max concentration

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CAS 111-76-2 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

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A substance identified by CAS 111-76-2 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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