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Annex II Entry 682 CMR15/10/2010

Acrylonitrile

Acrylonitrile is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 682
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 107-13-1
CAS 107-13-1PubChem CID 7855

Acrylonitrile

Acrylonitrile is a nitrile that is hydrogen cyanide in which the hydrogen has been replaced by an ethenyl group. It has a role as a mutagen, an antifungal agent, a polar aprotic solvent, a carcinogenic agent and a fungal metabolite. It is a volatile organic compound and an aliphatic nitrile. — ChEBI

IUPAC name
prop-2-enenitrile
Molecular formula
C3H3N
Molecular weight
53.06 g/mol
Exact mass
53.026549100 Da
XLogP3
0.2
Topological polar surface area
23.8 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

2-PropenenitrileVinyl cyanidePropenenitrileCyanoethyleneFumigrainVentoxCarbacrylAcritet
16 more reported names
AcrylonNitrile acryliqueCyanure de vinyleAcrylnitrilMiller's fumigrainAcrylonitrile monomerAkrylonitrylNitrile acrilicoCianuro di vinileAkrylonitrilVinylkyanidENT 54CyanoetheneTL 314RCRA waste number U009Acrylsaeurenitril
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:28217

acrylonitrile

A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by an ethenyl group.

Formula
C3H3N
Average mass
53.064 g/mol
Monoisotopic mass
53.02655 Da
Formal charge
0
  • volatile organic compound — is a (CHEBI:134179)
  • aliphatic nitrile — is a (CHEBI:80291)
  • antifungal agent — has role (CHEBI:35718)
  • carcinogenic agent — has role (CHEBI:50903)
  • polar aprotic solvent — has role (CHEBI:48358)
  • mutagen — has role (CHEBI:25435)
  • fungal metabolite — has role (CHEBI:76946)
  • antifungal agent — has role (CHEBI:35718)
  • carcinogenic agent — has role (CHEBI:50903)
  • polar aprotic solvent — has role (CHEBI:48358)
  • mutagen — has role (CHEBI:25435)
  • fungal metabolite — has role (CHEBI:76946)
  • volatile organic compound — is a (CHEBI:134179)
  • aliphatic nitrile — is a (CHEBI:80291)
Additional curated names
acrylonitrile2-propenenitrileAcrylnitrilAcrylonitrileAcrylsaeurenitrilcyanure de vinylenitrile acryliquePropenenitrileVinyl cyanide
Cross-references from this source
  • CAS: 107-13-1 — ChemIDplus
  • CAS: 107-13-1 — KEGG COMPOUND
  • CAS: 107-13-1 — NIST Chemistry WebBook
  • MANUAL_X_REF: 2545 — PPDB
  • MANUAL_X_REF: 6AC — PDBeChem
  • MANUAL_X_REF: c0148 — UM-BBD
  • MANUAL_X_REF: C01998 — KEGG COMPOUND
  • MANUAL_X_REF: C01998 — KEGG COMPOUND
  • REGISTRY_NUMBER: 605310 — Reaxys

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2025-01-17. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7855

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: Warning: Effects, including skin reactions, may be delayed. Caution is advised. Vital signs should be monitored closely. Heart palpitation may begin within minutes after exposure.; Note: Acrylonitrile is very readily absorbed through the skin.; Signs and Symptoms of Acrylonitrile Exposure: Signs and symptoms of acute exposure to acrylonitrile may include hypertension (high blood pressure) and tachycardia (rapid heart rate), followed by hypotension (low blood pressure) and bradycardia (slow heart rate). Cherry-red mucous membranes and blood, cardiac arrhythmias, and other cardiac abnormalities are common. Cyanosis (blue tint to the skin and mucous membranes) is not a consistent finding. Tachypnea (rapid respiratory rate) may be followed by respiratory depression. Lung hemorrhage and pulmonary edema may also occur. Headache, vertigo (dizziness), agitation, and giddiness may be followed by combative behavior, convulsions, paralysis, protruding eyeballs, dilated and unreactive pupils, and coma. Acrylonitrile is irritating to the skin and mucous membranes. Lacrimation (tearing) and a burning sensation of the mouth and throat are common. Excessive salivation, nausea, and vomiting may als Source: CAMEO Chemicals
  • ERG2024, Guide 131P (Acrylonitrile, stabilized): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and wash the skin with water. If symptoms occur after washing, get medical attention immediately.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H301: Toxic if swallowed [Danger Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H350: May cause cancer [Danger Carcinogenicity]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P332+P317, P333+P317, P361+P364, P362+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for 0.2% (2 of 1097) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H225 (99.8%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H301 (97.8%): Toxic if swallowed [Danger Acute toxicity, oral]; H311 (97.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H315 (99.8%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (99.8%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (99.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H331 (97.1%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H335 (99.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H350 (99.8%): May cause cancer [Danger Carcinogenicity]; H361 (15.2%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H411 (97.8%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P332+P317, P333+P317, P361+P364, P362+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1097 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 2 of 1097 reports by companies.; There are 26 notifications provided by 1095 of 1097 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H301: Toxic if swallowed [Danger Acute toxicity, oral]; H310: Fatal in contact with skin [Danger Acute toxicity, dermal]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H330: Fatal if inhaled [Danger Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H350: May cause cancer [Danger Carcinogenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardou Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P319, P320, P321, P330, P332+P317, P333+P317, P361+P364, P362+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Health Effects: Exposure to high levels of cyanide for a short time harms the brain and heart and can even cause coma, seizures, apnea, cardiac arrest and death. Chronic inhalation of cyanide causes breathing difficulties, chest pain, vomiting, blood changes, headaches, and enlargement of the thyroid gland. Skin contact with cyanide salts can irritate and produce sores. (L96, L97) Source: Toxin and Toxin Target Database (T3DB)
  • NFPA Health Rating: 4 - Materials that, under emergency conditions, can be lethal. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 2 - Materials that readily undergo violent chemical changes at elevated temperatures and pressures. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Specific Notice: W - No water: Materials that react violently or explosively with water. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Acrylonitrile is a clear, colorless liquid at room temperature. Acrylonitrile is used as a monomer for acrylic and modacrylic fibers and whiskers, in copolymers with styrene and butadiene (ABS resins), in the manufacture of adiponitrile, and in nitrile rubbers. Acrylonitrile is no longer used as a fumigant and nitrile resins made with acrylonitrile are no longer used to make beverage bottles. HUMAN STUDIES: Dermal exposure to acrylonitrile causes irritation, burns, and blisters. Additionally, dermal exposure to acrylonitrile can lead to systemic toxicity and lethality. Chronic effects can also occur after exposure to acrylonitrile vapors or liquid. 576 Japanese workers exposed to 5-20 ppm acrylonitrile over 10 yr showed headache, fatigue, nausea, and weakness with symptoms of anemia, jaundice, conjunctivitis, and abnormal whole blood and serum specific gravity, cholinesterase, urobilinogen, bilirubin, urinary protein, and sugar values, indicative of liver injury and a general toxic effect. In cultured human bronchial epithelial cells acrylonitrile induced cytotoxicity, sister chromatid exchanges and DNA single strand breaks. Acrylonitrile affected semen qual Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxic cyanide ions or hydrogen cyanide. Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. Cyanide is also known produce some of its toxic effects by binding to catalase, glutathione peroxidase, methemoglobin, hydroxocobalamin, phosphatase, tyrosinase, ascorbic acid oxidase, xanthine oxidase, succinic dehydrogenase, and Cu/Zn superoxide dismutase. Cyanide binds to the ferric ion of methemoglobin to form inactive cyanmethemoglobin. (L97) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: A whole body BCF of 48 was determined for bluegills exposed to acrylonitrile for 28 days (or until equilibrium was obtained) in a flowing water system(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 29(SRC), determined from a log Kow of 0.25(2) and a regression-derived equation(3), indicates that acrylonitrile is expected to have very high mobility in soil(SRC). Volatilization of acrylonitrile from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 1.38X10-4 atm-cu m/mole(4). Acrylonitrile is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 109 mm Hg at 25 °C(5). Complete biodegradation of a low concentration of acrylonitrile was <2 days to 6 days depending on soil type with slow degradation reported in unacclimated soils exposed to high concentrations of acrylonitrile(6); these findings suggest that biodegradation may be an important environmental fate process in soil under certain conditions(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 29(SRC), determined from a log Kow of 0.25(2) and a regression-derived equation(3), indicates that acrylonitrile is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon a Henry's Law constant of 1.38X10-4 atm-cu m/mole(5). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 7 hrs and 4 days, respectively(SRC). According to a classification scheme(6), a BCF of 48(7) suggests bioconcentration in aquatic organisms is moderate(SRC). Acrylonitrile was stable to aqueous hydrolysis in the pH range of 4-10 over a 10-day observation period(8) suggesting that hydrolyis is not important under environmental conditions (pH 5 to 9). Complete degradation in 6-20 days using various freshwater inoculums(8,9) suggests that biodegradation may be an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), acrylonitrile, which has a vapor pressure of 109 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase acrylonitrile is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.5 hours(SRC), calculated from its rate constant of 1.11X10-11 cu cm/molecule-sec at 25 °C(3). The half-life for reaction with ozone in air is estimated to be 83 days(SRC), calculated from its rate constant of 1.38X10-19 cu cm/molecule-sec at 25 °C(4). Acrylonitrile does not absorb UV light at wavelengths >290 nm(5) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Acrylonitrile is primarily used in the manufacture of acrylic and modacrylic fibers. It is also used as a raw material in the manufacture of plastics (acrylonitrile-butadiene-styrene and styrene-acrylonitrile resins), adiponitrile, acrylamide, and nitrile rubbers and barrier resins. Source: EPA Hazardous Air Pollutants
  • Sources/Uses: Used as a monomer in the production of acrylic fibers and acrylonitrile-butadiene-styrene resins; Also used to produce adiponitrile; Was used in the past as a fumigant and to make nitrile resins for beverage bottles; [ACGIH] Used in the plastics, coatings, and adhesive industries; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Restricted Notes: No longer used as a fumigant in the U.S. [EPA Pesticides] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Working with Glues and Adhesives [Category: Other]; Firefighting [Category: Other]; Burning Synthetic Polymers [Category: Burn] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For acrylonitrile (USEPA/OPP Pesticide Code: 000601) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: ... Cyanoethylation of cotton; synthetic soil blocks (acrylonitrile polymerized wood pulp); ... monomer for a semiconductive polymer that can be used like inorganic oxide catalysts in dehydrogenation of tert-butanol to isobutylene and water. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: The major end uses of acrylonitrile are acrylic fiber, acrylonitrile-butadiene-styrene (ABS) resins, adiponitrile, acrylamide, nitrile rubbers, and carbon fibers. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Acrylonitrile is used as a monomer for acrylic and modacrylic fibers and whiskers; in copolymers with styrene and butadiene (ABS resins); in the manufacture of adiponitrile; and in nitrile rubbers. Acrylonitrile is no longer used as a fumigant and nitrile resins made with acrylonitrile are no longer used to make beverage bottles. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for Acrylonitrile (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Acrylonitrile is used principally as a monomer in the manufacture of synthetic polymers, especially polyacrylonitrile which comprises acrylic fibers. Acrylic fibers are, among other uses, precursor for well-known carbon-fiber. It is also a component of synthetic rubber and small amounts may be used as a fumigant. (L583) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Acrylonitrile

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B✓——

Key data

CAS
107-13-1
EC
203-466-5
Annex
II
Entry number
682

Inventory links for Acrylonitrile

Inventory Restriction reference
Ref 95285

ACRYLONITRILE

CAS: 107-13-1
EC: 203-466-5

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 683
Nearby record in the same annex

2-Nitropropane

CAS: 79-46-9
EC: 201-209-1
Annex II 685
Nearby record in the same annex

2-Nitroanisole

CAS: 91-23-6
EC: 202-052-1
Annex II 686
Nearby record in the same annex

4-Nitrobiphenyl

CAS: 92-93-3
EC: 202-204-7
Annex II 688
Nearby record in the same annex

Binapacryl

CAS: 485-31-4
EC: 207-612-9

What Annex II means for Acrylonitrile

Acrylonitrile is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Acrylonitrile is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 107-13-1 is the unique numerical identifier assigned to Acrylonitrile by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Acrylonitrile has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Acrylonitrile

This page summarizes one Annex II record for Acrylonitrile from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Acrylonitrile, but confirm any final regulatory decision against the current official annex wording and source files.

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