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Annex II Entry 681 CMR21/10/2010

Acrylamide, unless regulated elsewhere in this Regulation

Acrylamide, unless regulated elsewhere in this Regulation is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 681
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 79-06-1
CAS 79-06-1PubChem CID 6579

Acrylamide

Acrylamide is a member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia. It has a role as an alkylating agent, a mutagen, a carcinogenic agent, a neurotoxin and a Maillard reaction product. It is a primary carboxamide, a member of acrylamides and a N-acylammonia. It is functionally related to an acrylic acid. — ChEBI

IUPAC name
prop-2-enamide
Molecular formula
C3H5NO
Molecular weight
71.08 g/mol
Exact mass
71.037113783 Da
XLogP3
-0.7
Topological polar surface area
43.1 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

2-PropenamidePropenamideAcrylic acid amideAcrylic amideEthylenecarboxamideVinyl amideAkrylamidAcrylagel
16 more reported names
PropeneamideOptimumAmresco Acryl-40Propenoic acid amideEthylene CarboxamideAmid kyseliny akryloveRCRA waste number U007Acrylamide Monomer20R035KLCICHEBI:28619AI3-04119NSC-7785DTXCID6027RefChem:5514Acrylic acid amide (50%)201-173-7
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Acrylamide, unless regulated elsewhere in this Regulation

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B✓✓—
Cat. 2——✓

Key data

CAS
79-06-1
EC
201-173-7
Annex
II
Entry number
681

Inventory links for Acrylamide, unless regulated elsewhere in this Regulation

Inventory Restriction reference
Ref 95284

ACRYLAMIDE

CAS: 79-06-1
EC: 201-173-7
Inventory Restriction reference
Ref 95299

METHACRYLAMIDE

CAS: 79-39-0
EC: 201-202-3

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 682
Nearby record in the same annex

Acrylonitrile

CAS: 107-13-1
EC: 203-466-5
Annex II 683
Nearby record in the same annex

2-Nitropropane

CAS: 79-46-9
EC: 201-209-1
Annex II 685
Nearby record in the same annex

2-Nitroanisole

CAS: 91-23-6
EC: 202-052-1
Annex II 686
Nearby record in the same annex

4-Nitrobiphenyl

CAS: 92-93-3
EC: 202-204-7

What Annex II means for Acrylamide, unless regulated elsewhere in this Regulation

Acrylamide, unless regulated elsewhere in this Regulation is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Acrylamide, unless regulated elsewhere in this Regulation is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 79-06-1 is the unique numerical identifier assigned to Acrylamide, unless regulated elsewhere in this Regulation by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Acrylamide, unless regulated elsewhere in this Regulation has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Acrylamide, unless regulated elsewhere in this Regulation

This page summarizes one Annex II record for Acrylamide, unless regulated elsewhere in this Regulation from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Acrylamide, unless regulated elsewhere in this Regulation, but confirm any final regulatory decision against the current official annex wording and source files.

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