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Annex II Entry 406 15/10/2010

4-Ethoxy-m-phenylenediamine and its salts

4-Ethoxy-m-phenylenediamine and its salts is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 406

Chemical identity and properties

PubChem 2D chemical structure for CAS 5862-77-1
CAS 5862-77-1PubChem CID 49981

2,4-Diamino-1-ethoxybenzene

IUPAC name
4-ethoxybenzene-1,3-diamine
Molecular formula
C8H12N2O
Molecular weight
152.19 g/mol
Exact mass
152.094963011 Da
XLogP3
0.9
Topological polar surface area
61.3 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

2,4-Diaminoethoxybenzene2,4-Diaminophenetole4-ETHOXY-1,3-BENZENEDIAMINEm-Phenylenediamine, 4-ethoxy-1,3-Benzenediamine, 4-ethoxy-C.I. 76055U3BC329BNWRefChem:908727
11 more reported names
3-Amino-4-ethoxyphenylamine4-Ethoxy-m-phenylenediamineETHOXYPHENYLENE-2,4-DIAMINECCRIS 5791BRN 2089860UNII-U3BC329BNW2-13-00-00308 (Beilstein Handbook Reference)2,4-DIAMINOPHENETOLE-NQHVJMJEWQQXBS-UHFFFAOYSA-NDIAMINOETHOXYBENZENE, 2,4-AS-8006
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 6219-69-8
CAS 6219-69-8CAS 68015-98-5PubChem CID 50020

4-Ethoxy-1,3-benzenediamine sulfate

IUPAC name
4-ethoxybenzene-1,3-diamine;sulfuric acid
Molecular formula
C8H14N2O5S
Molecular weight
250.27 g/mol
Exact mass
250.06234272 Da
Topological polar surface area
144.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
7
Covalent units
2
Defined stereocentres
0

Also known as

4-Ethoxy-m-phenylenediamine sulfateC.I. oxidation base 14A1,3-Benzenediamine, 4-ethoxy-, sulfate (1:1)HSDB 6239RODOL EOXEINECS 268-164-8m-Phenylenediamine, 4-ethoxy-, sulfate4-Ethoxybenzene-1,3-diammonium sulphate
16 more reported names
C.I. 760564-ETHOXY-1,3-PHENYLENEDIAMINE SULFATERefChem:5225764Ethoxymphenylenediamine sulfate4Ethoxybenzene1,3diammonium sulphate1,3Benzenediamine, 4ethoxy, sulfate (1:1)4-ETHOXY-M-PHENYLENEDIAMINE SULFATE [INCI]268-164-84-Ethoxybenzene-1,3-diamine sulfate2,4-Diamino phenetole sulfate2,4-DIAMINOPHENETOLE SULFATE4-ethoxybenzene-1,3-diamine; sulfuric acid1,3-Benzenediamine, 4-ethoxy-, sulfateXPX558J12N4-Ethoxybenzene-13-diamine sulfateUNII-XPX558J12N
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 67801-06-3
CAS 67801-06-3PubChem CID 49980

1,3-Benzenediamine, 4-ethoxy-, hydrochloride (1:2)

IUPAC name
4-ethoxybenzene-1,3-diamine;dihydrochloride
Molecular formula
C8H14Cl2N2O
Molecular weight
225.11 g/mol
Exact mass
224.0483185 Da
Topological polar surface area
61.3 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
3
Covalent units
3
Defined stereocentres
0

Also known as

4-ETHOXY-1,3-BENZENEDIAMINE DIHYDROCHLORIDE2,4-Diaminophenetole, dihydrochloride4-Ethoxy-1,3-phenylenediamine, dihydrochloride1,3-Benzenediamine, 4-ethoxy-, dihydrochloride3MLJ55E9H7m-Phenylenediamine, 4-ethoxy-, dihydrochlorideRefChem:1052661267-125-2
8 more reported names
4-Ethoxybenzene-1,3-diammonium dichlorideHSDB 6238EINECS 267-125-2UNII-3MLJ55E9H74-Ethoxy-m-phenylenediamine dihydrochlorideWDQOMIASNLKYHY-UHFFFAOYSA-N4-Ethoxybenzene-1,3-diamine--hydrogen chloride (1/2)4-ETHOXY-1,3-BENZENEDIAMINE DIHYDROCHLORIDE [HSDB]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

4-Ethoxy-m-phenylenediamine and its salts

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Identified ingredients

Key data

CAS
67801-06-3 / 5862-77-1 / 68015-98-5 / 6219-69-8
EC
267-125-2 / - / 268-164-8 / -
Annex
II
Entry number
406

Inventory links for 4-Ethoxy-m-phenylenediamine and its salts

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 409
Nearby record in the same annex

Pyrogallol

CAS: 87-66-1
EC: 201-762-9
Annex II 400
Nearby record in the same annex

1,2-Epoxybutane

CAS: 106-88-7
EC: 203-438-2

What Annex II means for 4-Ethoxy-m-phenylenediamine and its salts

4-Ethoxy-m-phenylenediamine and its salts is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 4-Ethoxy-m-phenylenediamine and its salts is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 67801-06-3 / 5862-77-1 / 68015-98-5 / 6219-69-8 is the unique numerical identifier assigned to 4-Ethoxy-m-phenylenediamine and its salts by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 4-Ethoxy-m-phenylenediamine and its salts

This page summarizes one Annex II record for 4-Ethoxy-m-phenylenediamine and its salts from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 4-Ethoxy-m-phenylenediamine and its salts, but confirm any final regulatory decision against the current official annex wording and source files.

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