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Annex II Entry 33 17/10/2010

Xylidines, their isomers, salts and halogenated and sulphonated derivatives

Xylidines, their isomers, salts and halogenated and sulphonated derivatives is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 33

Chemical identity and properties

PubChem 2D chemical structure for CAS 1300-73-8
CAS 1300-73-8PubChem CID 56846457

Xylidine

Xylidines is a pale-yellow to brown liquid with a weak, aromatic, amine-like odor. (NIOSH, 2024) — CAMEO Chemicals

IUPAC name
2,3-dimethylaniline;2,4-dimethylaniline;2,5-dimethylaniline;2,6-dimethylaniline;3,4-dimethylaniline;3,5-dimethylaniline
Molecular formula
C48H66N6
Molecular weight
727.1 g/mol
Exact mass
726.53489613 Da
Topological polar surface area
156.0 Ų
Hydrogen-bond donors
6
Hydrogen-bond acceptors
6
Covalent units
6
Defined stereocentres
0

Also known as

aminoxyleneXilidineXylidinenXylidinesXylidine isomersAminodimethylbenzeneRefChem:53412UNII-0V872Q19HT
10 more reported names
HSDB 64640V872Q19HTEINECS 215-091-4AI3-24178-X (USDA)Xylidine mixed ortho-meta-para isomersEC 215-091-4DimethylaminobenzeneXylidine (mixture)CDULGHZNHURECF-UHFFFAOYSA-NC48H66N6
Open full PubChem recordPubChem annotations3D structure image

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match56846457

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: Excerpt from NIOSH Pocket Guide for Xylidine:; Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: SOAP WASH IMMEDIATELY - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.; Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.; Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024) Source: CAMEO Chemicals
  • ERG2024, Guide 153 (Xylidines, solid; Xylidines, liquid): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301+H311+H331 (21.3%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]; H301+H311 (56.8%): Toxic if swallowed or in contact with skin [Danger Acute toxicity, oral; acute toxicity, dermal]; H301 (98.9%): Toxic if swallowed [Danger Acute toxicity, oral]; H311 (98.4%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H315 (56.8%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (57.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H330 (57.9%): Fatal if inhaled [Danger Acute toxicity, inhalation]; H331 (41.5%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H351 (57.9%): Suspected of causing cancer [Warning Carcinogenicity]; H373 (99.5%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H411 (99.5%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P318, P319, P320, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 183 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H330: Fatal if inhaled [Danger Acute toxicity, inhalation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P280, P284, P301+P317, P302+P352, P304+P340, P305+P351+P338, P308+P316, P316, P317, P318, P319, P320, P321, P330, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: Estimated(using structure estimation method and a recommended regression derived equation)(1,2) and measured BCF values for the six isomers of xylidine(SRC), ranged from <10 to 26. According to a classification scheme(3), these BCF values suggest that bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a recommended classification scheme(1), estimated Koc values ranging from 52 to 240(SRC), determined from a structure estimation method(2), indicate that xylidine is expected to have high to medium mobility in soil(SRC). However, anilines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(3,4), suggesting that mobility may be much lower in some soils(SRC). Volatilization of xylidine may be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 2.5X10-6 atm-cu m/mole(SRC), using a fragment constant estimation method(5). Xylidine is not expected to volatilize from dry soil surfaces based on measured vapor pressures ranging from 0.028 to 0.15 mm Hg for the six isomers(SRC). Limited data suggest that xylidine may biodegrade in soil under aerobic conditions(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a recommended classification scheme(1), estimated Koc values ranging from 52 to 240(SRC) indicate that xylidine is not expected to adsorb to suspended solids and sediment in water(SRC). However, aromatic amine groups are recognized as having a strong affinity for organic carbon, suggesting that this compound may bind strongly to suspended organic material in water(2,3). Xylidine may volatilize from water surfaces(4,SRC) based on an estimated Henry's Law constant of 2.5X10-6 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). Estimated volatilization half-lives for a model river and model lake are 16 and 120 days, respectively(4,SRC). According to a classification scheme(5), estimated and measured BCF values for the six isomers(6,SRC), suggest that bioconcentration in aquatic organisms is low(SRC). Limited biodegradation data indicate that xylidine may be biodegraded under aerobic conditions in aquatic systems(SRC). Hydrolysis is not expected to occur due to lack of functional groups to hydrolyze(7,SRC). As a class, aromatic amines react relatively rapidly in sunlit natural water via reaction with photochemically produced hydroxyl rad Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), xylidine, which has vapor pressures ranging from 0.028 to 0.15 mm Hg at 25 °C for the six isomers(2,SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase xylidine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is expected to be about 2.0 hours based on the estimated half-lives for the six isomers(3,SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Xylidines, their isomers, salts and halogenated and sulphonated derivatives

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
1300-73-8
EC
215-091-4
Annex
II
Entry number
33

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 38
Nearby record in the same annex

Anthracene oil

CAS: 120-12-7
EC: 204-371-1

What Annex II means for Xylidines, their isomers, salts and halogenated and sulphonated derivatives

Xylidines, their isomers, salts and halogenated and sulphonated derivatives is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Xylidines, their isomers, salts and halogenated and sulphonated derivatives is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 1300-73-8 is the unique numerical identifier assigned to Xylidines, their isomers, salts and halogenated and sulphonated derivatives by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Xylidines, their isomers, salts and halogenated and sulphonated derivatives

This page summarizes one Annex II record for Xylidines, their isomers, salts and halogenated and sulphonated derivatives from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Xylidines, their isomers, salts and halogenated and sulphonated derivatives, but confirm any final regulatory decision against the current official annex wording and source files.

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