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Annex II Entry 32 17/10/2010

Toluidines, their isomers, salts and halogenated and sulphonated derivatives

Toluidines, their isomers, salts and halogenated and sulphonated derivatives is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 32

Chemical identity and properties

PubChem 2D chemical structure for CAS 26915-12-8
CAS 26915-12-8PubChem CID 7813

p-Toluidine

P-toluidine is an aminotoluene in which the amino substituent is para to the methyl group. — ChEBI

IUPAC name
4-methylaniline
Molecular formula
C7H9N
Molecular weight
107.15 g/mol
Exact mass
107.073499291 Da
XLogP3
1.4
Topological polar surface area
26.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

106-49-04-Toluidine4-Methylbenzenaminep-Tolylamine4-AMINOTOLUENEp-MethylanilineBenzenamine, 4-methyl-p-Toluidin
16 more reported names
p-Aminotoluenep-Methylbenzenamine1-Amino-4-methylbenzeneNaphtol AS-KGNaphtol AS-KGLLAniline, p-methyl-4-Aminotoluen4-methylphenylamine4-Amino-1-methylbenzeneRCRA waste number U353C.I. Azoic Coupling Component 107NSC 15350para-toluidineC.I. 37107Aniline, 4-methyl-I1D0KL7I4U
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Toluidines, their isomers, salts and halogenated and sulphonated derivatives

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
26915-12-8
EC
248-105-2
Annex
II
Entry number
32

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 26
Nearby record in the same annex

Benzidine

CAS: 92-87-5
EC: 202-199-1
Annex II 38
Nearby record in the same annex

Anthracene oil

CAS: 120-12-7
EC: 204-371-1

What Annex II means for Toluidines, their isomers, salts and halogenated and sulphonated derivatives

Toluidines, their isomers, salts and halogenated and sulphonated derivatives is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Toluidines, their isomers, salts and halogenated and sulphonated derivatives is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 26915-12-8 is the unique numerical identifier assigned to Toluidines, their isomers, salts and halogenated and sulphonated derivatives by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Toluidines, their isomers, salts and halogenated and sulphonated derivatives

This page summarizes one Annex II record for Toluidines, their isomers, salts and halogenated and sulphonated derivatives from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Toluidines, their isomers, salts and halogenated and sulphonated derivatives, but confirm any final regulatory decision against the current official annex wording and source files.

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