2-Amino-1,2-bis(4-methoxyphenyl)ethanol and its salts
2-Amino-1,2-bis(4-methoxyphenyl)ethanol and its salts is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Chemical identity and properties
Evaclin; Evadol; Isodianidylethanolamine; LC 2
- IUPAC name
- 2-amino-1,2-bis(4-methoxyphenyl)ethanol
- Molecular formula
- C16H19NO3
- Molecular weight
- 273.33 g/mol
- Exact mass
- 273.13649347 Da
- XLogP3
- 1.6
- Topological polar surface area
- 64.7 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
External database identifiers
- EPA DTXSID:DTXSID501023808
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
2-Amino-1,2-bis(4-methoxyphenyl)ethanol and its salts
Chemical / IUPAC name
Evadol hydrochloride; Benzeneethanol, beta-amino-4-methoxy-alpha-(4-methoxyphenyl)-, hydrochloride
Regulatory information
Key data
Related records for 2-Amino-1,2-bis(4-methoxyphenyl)ethanol and its salts
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
Octodrine (INN) and its salts
1,3-Dimethylpentylamine and its salts
Tuaminoheptane (INN), its isomers and salts
4-Aminosalicylic acid and its salts
Toluidines, their isomers, salts and halogenated and sulphonated derivatives
Procainamide (INN), its salts and derivatives
Xylidines, their isomers, salts and halogenated and sulphonated derivatives
Imperatorin (9-(3-methylbut-2-enyloxy)furo[3,2-g]chromen-7-one)
Ammi majus L. and its galenical preparations
What Annex II means for 2-Amino-1,2-bis(4-methoxyphenyl)ethanol and its salts
2-Amino-1,2-bis(4-methoxyphenyl)ethanol and its salts is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
Frequently asked questions
Source note for Annex II record 2-Amino-1,2-bis(4-methoxyphenyl)ethanol and its salts
This page summarizes one Annex II record for 2-Amino-1,2-bis(4-methoxyphenyl)ethanol and its salts from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for 2-Amino-1,2-bis(4-methoxyphenyl)ethanol and its salts, but confirm any final regulatory decision against the current official annex wording and source files.
Tools & next steps
Check your formula
Paste a full INCI list to detect 2-Amino-1,2-bis(4-methoxyphenyl)ethanol and its salts and other flagged EU annex records in one pass.
INCI CheckerCompare entries
Compare 2-Amino-1,2-bis(4-methoxyphenyl)ethanol and its salts side by side with another annex record to review differences in restrictions, concentrations and annex placement.
CompareBrowse the annex
See all records in Annex II and compare regulatory conditions across substances in this annex.
Open Annex II