What is CAS 110-46-3 for Amyl nitrites?

CAS 110-46-3 is the unique numerical identifier assigned to Amyl nitrites by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

Annex II Entry 247 15/10/2010

Amyl nitrites

Q: How do I check if my product formula contains Amyl nitrites?

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Amyl nitrites is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 247

Chemical identity and properties

PubChem 2D chemical structure for CAS 110-46-3

CAS 110-46-3PubChem CID 8053

Isoamyl Nitrite

Isoamyl nitrite is a nitrite ester having isopentyl as the alkyl group. It has a role as a vasodilator agent and an antihypertensive agent. It is functionally related to an isoamylol. — ChEBI

IUPAC name: 3-methylbutyl nitrite

Molecular formula: C5H11NO2
Molecular weight: 117.15 g/mol
Exact mass: 117.078978594 Da
XLogP3: 1.7
Topological polar surface area: 38.7 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

Isopentyl nitriteVaporoleAmilnitriteAspiralNitrous acid, 3-methylbutyl ester3-Methylbutanol nitritePentanoli nitrisNitrous acid, isopentyl ester

16 more reported names

Isopentyl alcohol, nitriteAmyl nitrosum5N0U5TUC9ZNSC-7903CHEBI:2691Nitrite, AmylRefChem:54193Nitrous acid, 3-methyl butyl ester203-770-81-PENTYL NITRITE22T8Z09XAKAmyl NitriteNitramylNitrous Acid, 2-methylbutyl Ester, mixt. with 3-methylbutylnitriteAmyl nitrite INitramyl (VAN)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:2691
ChEMBL:CHEMBL1535371
EPA DTXSID:DTXSID9025455
PubMed:22606955
PubMed:22268155
PubMed:22174654
PubMed:21711620
PubMed:21587610
PubMed:21581251
PubMed:21495143
PubMed:20416372
PubMed:19425783
PubMed:19294290
PubMed:19109018
PubMed:18940810

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match8053

Attributed physical-property, hazard, environmental and use annotations.

Autoignition Temperature: 408 °F (NTP, 1992) Source: CAMEO Chemicals
Autoignition Temperature: 408 °F Source: Hazardous Substances Data Bank (HSDB)
Autoignition Temperature: 209 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Boiling Point: 205 to 210 °F at 760 mmHg (NTP, 1992) Source: CAMEO Chemicals
Boiling Point: 99.2 °C Source: Hazardous Substances Data Bank (HSDB)
Boiling Point: 99.2 °C Source: Human Metabolome Database (HMDB)
Boiling Point: 97-99 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Boiling Point: 99.2 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy

Color/Form: Yellowish, transparent liquid Source: Hazardous Substances Data Bank (HSDB)

Density: 0.8528 at 68 °F (NTP, 1992) - Less dense than water; will float Source: CAMEO Chemicals
Density: 0.875 @ 25 °C Source: Hazardous Substances Data Bank (HSDB)
Density: Relative density (water = 1): 0.875 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Density: 0.8828 @ 20°C Source: PAC Chemical Database, U.S. Department of Energy

Flash Point: less than 69 °F (NTP, 1992) Source: CAMEO Chemicals
Flash Point: 3 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Odor: Penetrating fragrant, somewhat fruity odor Source: Hazardous Substances Data Bank (HSDB)

Physical Description: Isoamyl nitrite is a clear yellow liquid. (NTP, 1992) Source: CAMEO Chemicals
Physical Description: Yellowish transparent liquid with a penetrating, somewhat fruity odor; Unstable, decomposed by light and air; [Merck Index] Colorless liquid; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Physical Description: Liquid Source: Human Metabolome Database (HMDB)
Physical Description: YELLOW LIQUID WITH CHARACTERISTIC ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Refractive Index: Index of refraction: 1.3918 @ 20 °C Source: Hazardous Substances Data Bank (HSDB)

Solubility: less than 0.1 mg/mL at 64 °F (NTP, 1992) Source: CAMEO Chemicals
Solubility: MISCIBLE WITH ETHER, ALCOHOL, CHLOROFORM Source: Hazardous Substances Data Bank (HSDB)
Solubility: Very slightly soluble in water Source: Hazardous Substances Data Bank (HSDB)
Solubility: Solubility in water: none Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Vapor Pressure: 26.3 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Vapor Pressure: Vapor pressure, kPa at 20 °C: 3.5 Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Exposure Routes: The substance can be absorbed into the body by inhalation and through the skin. Source: ILO-WHO International Chemical Safety Cards (ICSCs)

First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
ERG2024, Guide 129 (Amyl nitrite): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)

Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P317, P303+P361+P353, P304+P340, P317, P330, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H314 (13.5%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317 (13.5%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (13.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332 (93.2%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H341 (13.5%): Suspected of causing genetic defects [Warning Germ cell mutagenicity] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P318, P321, P330, P333+P317, P362+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 74 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: NITE-CMC
GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
Precautionary Statement Codes: P261, P272, P273, P280, P302+P352, P321, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement) Source: NITE-CMC
Signal: Danger Source: NITE-CMC
GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] Source: NITE-CMC

Sources/Uses: Used in perfumes and to make diazonium compounds; Also used as a drug (vasodilator for angina and antidote for hydrogen cyanide poisoning); [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: Used in perfumes; preparation of diazonium compounds Source: Hazardous Substances Data Bank (HSDB)
Uses: Used as a vasodilator in angina therapy in the treatment of hydrogen cyanide and hydrogen sulfide poisonings, and as an industrial chemical and perfume scent Source: Hazardous Substances Data Bank (HSDB)
Uses: MEDICATION Source: Hazardous Substances Data Bank (HSDB)
Uses: MEDICATION (VET) Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Amyl nitrites

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS

110-46-3

203-770-8

Annex

Entry number

247

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 246