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Annex II Entry 242 15/10/2010

1- and 2-Naphthylamines and their salts

1- and 2-Naphthylamines and their salts is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 242

Chemical identity and properties

PubChem 2D chemical structure for CAS 134-32-7
CAS 134-32-7PubChem CID 8640

1-Naphthylamine

1-naphthylamine is a naphthylamine that is naphthalene substituted by an amino group at position 1. It has a role as a human xenobiotic metabolite. — ChEBI

IUPAC name
naphthalen-1-amine
Molecular formula
C10H9N
Molecular weight
143.18 g/mol
Exact mass
143.073499291 Da
XLogP3
2.2
Topological polar surface area
26.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

1-Aminonaphthalene1-Naphthalenaminealpha-NaphthylamineNaphthalidineNaphthalen-1-ylamineFast Garnet Base BNaphthalidam1-Naphthalamine
16 more reported names
1-Naphthylamin1-Naftilaminaalpha-AminonaphthaleneAlfanaftilaminaFast Garnet B Base1-Aminonaftalen1-Naftylamine1-NaftylaminAlfa-naftyloaminaRCRA waste number U167alpha-Naftalaminalpha-NaftylaminC.I. Azoic Diazo Component 114CI Azoic Diazo Component 114CI 37265CHEBI:50450
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 91-59-8
CAS 91-59-8PubChem CID 7057

2-Naphthylamine

2-naphthylamine is a naphthylamine carrying the amino group at position 2. It has a role as a carcinogenic agent. — ChEBI

IUPAC name
naphthalen-2-amine
Molecular formula
C10H9N
Molecular weight
143.18 g/mol
Exact mass
143.073499291 Da
XLogP3
2.3
Topological polar surface area
26.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

2-Aminonaphthalene2-Naphthalenaminebeta-Naphthylamine6-Naphthylaminebeta-Naftilamina2-Naphthalamine2-NaphthylaminFast Scarlet Base B
16 more reported names
2-Aminonaftalen2-Naftylaminebeta-Naphthylamin2-Naftylaminbeta-Naftalaminbeta-NaftylaminNaphthalen-2-ylamine2-naftilaminabeta-naftyloaminaRCRA waste number U168USAF CB-222-Naphthylamine mustardC.I. 37270CKR7XL41N4CI 37270CHEBI:27878
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

1- and 2-Naphthylamines and their salts

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
91-59-8 / 134-32-7
EC
202-080-4 / 205-138-7
Annex
II
Entry number
242

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 241
Nearby record in the same annex

2-Naphthol

CAS: 135-19-3
EC: 205-182-7
Annex II 238
Nearby record in the same annex

Arecoline

CAS: 63-75-2
EC: 200-565-5
Annex II 247
Nearby record in the same annex

Amyl nitrites

CAS: 110-46-3
EC: 203-770-8

What Annex II means for 1- and 2-Naphthylamines and their salts

1- and 2-Naphthylamines and their salts is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 1- and 2-Naphthylamines and their salts is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 91-59-8 / 134-32-7 is the unique numerical identifier assigned to 1- and 2-Naphthylamines and their salts by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 1- and 2-Naphthylamines and their salts

This page summarizes one Annex II record for 1- and 2-Naphthylamines and their salts from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 1- and 2-Naphthylamines and their salts, but confirm any final regulatory decision against the current official annex wording and source files.

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