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Annex II Entry 214 20/10/2010

Decamethylenebis(trimethylammonium) salts, e.g. decamethonium bromide (INN)

Decamethylenebis(trimethylammonium) salts, e.g. decamethonium bromide (INN) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 214

Chemical identity and properties

PubChem 2D chemical structure for CAS 1420-40-2
CAS 1420-40-2PubChem CID 74014

Decamethonium iodide

IUPAC name
trimethyl-[10-(trimethylazaniumyl)decyl]azanium diiodide
Molecular formula
C16H38I2N2
Molecular weight
512.30 g/mol
Exact mass
512.11244 Da
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
3
Defined stereocentres
0

Also known as

Decamethonium diiodideTX886PAQ89RefChem:131173215-816-4EulixineEulissin AN1,N1,N1,N10,N10,N10-Hexamethyldecane-1,10-diaminium iodideDecamethylenebis(trimethylammonium iodide)
16 more reported names
trimethyl-[10-(trimethylazaniumyl)decyl]azanium;diiodideDecane-1,10-bis(trimethylammonium Iodide)DECAMETHONIUM IODIDE [MART.]ProcuranCS-01858691,10-Decanediaminium, N1,N1,N1,N10,N10,N10-hexamethyl-, iodide (1:2)Decamethionium iodideDecamethonium iodatumDekamethoniumjodidDekamethoniumjodid [Czech]EINECS 215-816-4trimethyl[10-(trimethylamino)decyl]amine, iodide, iodideUNII-TX886PAQ891,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-, diiodideDecamethonium iodide [INN:BAN]Dekamethylen-bis-trimethylamoniumjodid [Czech]
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 156-74-1
CAS 156-74-1PubChem CID 2968

Decamethonium

Decamethonium is a quaternary ammonium ion that is a depolarising muscle relaxant whose structure comprises a decane-1,10-diamine core in which each amino group carries three methyl substituents. It has a role as a nicotinic acetylcholine receptor agonist and a muscle relaxant. It derives from a hydride of a decane. — ChEBI

IUPAC name
trimethyl-[10-(trimethylazaniumyl)decyl]azanium
Molecular formula
C16H38N2+2
Molecular weight
258.49 g/mol
Exact mass
258.303499221 Da
XLogP3
3.9
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Covalent units
1
Defined stereocentres
0

Also known as

DecamethonumDECAMETHONIUM IONDecamethonium cation(DM)Br2N,N,N,N',N',N'-hexamethyldecane-1,10-diaminiumAmmonium, decamethylenebis(trimethyl-C1CG1S3T2W1,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-
16 more reported names
decamethylenebis(trimethylammonium)CHEBI:41934N,N,N,N',N',N'-hexamethyl-1,10-decanediaminiumtrimethyl[10-(trimethylazaniumyl)decyl]azaniumtrimethyl(10-(trimethylazaniumyl)decyl)azaniumdecamethylenebis(trimethylammonium)bromideRefChem:585339SyncurineDecacuranN1,N1,N1,N10,N10,N10-hexamethyldecane-1,10-diaminiumCHEMBL1134HSDB 3221CAS-541-22-0Lopac-D-1260Decane-1,10-bis(trimethylammonium bromide)UNII-C1CG1S3T2W
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 3198-38-7
CAS 3198-38-7PubChem CID 165087

Decamethonium chloride

IUPAC name
trimethyl-[10-(trimethylazaniumyl)decyl]azanium dichloride
Molecular formula
C16H38Cl2N2
Molecular weight
329.4 g/mol
Exact mass
328.2412046 Da
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
3
Defined stereocentres
0

Also known as

Decamethonium dichloride62I07N48KGAmmonium, decamethylenebis(trimethyl-, dichloride1,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-, dichlorideRefChem:919731trimethyl-[10-(trimethylazaniumyl)decyl]azanium;dichlorideN1,N1,N1,N10,N10,N10-Hexamethyldecane-1,10-diaminium chloride1,10-DECANEDIAMINIUM, N1,N1,N1,N10,N10,N10-HEXAMETHYL-, CHLORIDE (1:2)
7 more reported names
Decamethylenebis(trimethylammonium chloride)UNII-62I07N48KG1,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-, dichloride (9CI)EBC-139031trimethyl[10-(trimethylazaniumyl)decyl]azanium dichlorideN~1~,N~1~,N~1~,N~10~,N~10~,N~10~-Hexamethyldecane-1,10-bis(aminium) dichlorideN~1~,N~1~,N~1~,N~10~,N~10~,N~10~-Hexamethyldecane-1,10-bis(aminium)ato dichlorido
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 541-22-0
CAS 541-22-0PubChem CID 10921

Decamethonium dibromide

Crystals derived from methanol and acetone. (NTP, 1992) — CAMEO Chemicals

IUPAC name
trimethyl-[10-(trimethylazaniumyl)decyl]azanium dibromide
Molecular formula
C16H38Br2N2
Molecular weight
418.3 g/mol
Exact mass
418.13812 Da
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
3
Defined stereocentres
0

Also known as

Decamethylenebis(trimethylammonium bromide)Decamethylene bis(trimethylammonium bromide)Decamethylene-1,10-bistrimethylammonium dibromideAmmonium, decamethylenebis(trimethyl-, dibromideRefChem:54940DECAMETHONIUM BROMIDESyncurineDecamethonium (Bromide)
16 more reported names
DecacuranBromuro de decametonioDecamethonium bromideBromure de decamethonium1,10-Decanediaminium, N,N,N,N',N',N'-hexamethyl-, dibromideDecamethylene bis(trimethylammonium) dibromide55C6RK944KNSC-23004Dekamethoniumbromidtrimethyl[10-(trimethylazaniumyl)decyl]azanium dibromideCHEMBL1134Dekamethoniumbromid [Czech]Decametonio bromuroDecametonio bromuro [DCIT]Decamethonium bromide [INN]Decamethonii bromidum
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Decamethylenebis(trimethylammonium) salts, e.g. decamethonium bromide (INN)

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
156-74-1 / 541-22-0 / 1420-40-2 / 3198-38-7
EC
- / 208-772-2 / 215-816-4 / -
Annex
II
Entry number
214

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 213
Nearby record in the same annex

Iodine

CAS: 7553-56-2
EC: 231-442-4

What Annex II means for Decamethylenebis(trimethylammonium) salts, e.g. decamethonium bromide (INN)

Decamethylenebis(trimethylammonium) salts, e.g. decamethonium bromide (INN) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Decamethylenebis(trimethylammonium) salts, e.g. decamethonium bromide (INN) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 156-74-1 / 541-22-0 / 1420-40-2 / 3198-38-7 is the unique numerical identifier assigned to Decamethylenebis(trimethylammonium) salts, e.g. decamethonium bromide (INN) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Decamethylenebis(trimethylammonium) salts, e.g. decamethonium bromide (INN)

This page summarizes one Annex II record for Decamethylenebis(trimethylammonium) salts, e.g. decamethonium bromide (INN) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Decamethylenebis(trimethylammonium) salts, e.g. decamethonium bromide (INN), but confirm any final regulatory decision against the current official annex wording and source files.

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