Nitroxoline (INN) and its salts
Nitroxoline (INN) and its salts is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Chemical identity and properties
Nitroxoline
Nitroxoline is a monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5. It has a role as an antimicrobial agent, an antiinfective agent, an antifungal agent and a renal agent. It is a C-nitro compound and a monohydroxyquinoline. — ChEBI
- IUPAC name
- 5-nitroquinolin-8-ol
- Molecular formula
- C9H6N2O3
- Molecular weight
- 190.16 g/mol
- Exact mass
- 190.03784206 Da
- XLogP3
- 2.1
- Topological polar surface area
- 78.9 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:67121
- ChEMBL:CHEMBL1454910
- EPA DTXSID:DTXSID4046284
- PubMed:31638783
- PubMed:30939017
- PubMed:30184207
- PubMed:22728969
- PubMed:22695927
- PubMed:22391578
- PubMed:22289336
- PubMed:22073285
- PubMed:21969860
- PubMed:21899946
- PubMed:21598397
- PubMed:21384590
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
Nitroxoline (INN) and its salts
Chemical / IUPAC name
5-Nitro-8-quinolinol
Regulatory information
Key data
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What Annex II means for Nitroxoline (INN) and its salts
Nitroxoline (INN) and its salts is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
Frequently asked questions
Source note for Annex II record Nitroxoline (INN) and its salts
This page summarizes one Annex II record for Nitroxoline (INN) and its salts from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for Nitroxoline (INN) and its salts, but confirm any final regulatory decision against the current official annex wording and source files.
Tools & next steps
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