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Annex II Entry 208 15/10/2010

Fenadiazole (INN)

Fenadiazole (INN) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 208

Chemical identity and properties

PubChem 2D chemical structure for CAS 1008-65-7
CAS 1008-65-7PubChem CID 13883

Fenadiazole

Fenadiazole is a biaryl that is phenol which is substituted at position 2 by a 1,3,4-oxadiazol-2-yl group. Formerly used as a hypnotic drug. It has a role as a sedative. It is a member of phenols, a member of 1,3,4-oxadiazoles and a biaryl. — ChEBI

IUPAC name
2-(1,3,4-oxadiazol-2-yl)phenol
Molecular formula
C8H6N2O2
Molecular weight
162.15 g/mol
Exact mass
162.042927438 Da
XLogP3
1.1
Topological polar surface area
59.2 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

FenadiazolHypnazolEudormilViodorFenadiazolumJL 512o-1,3,4-Oxadiazol-2-ylphenolPHENOL, 2-(1,3,4-OXADIAZOL-2-YL)-
16 more reported names
Phenol, o-1,3,4-oxadiazol-2-yl-2-(o-Hydroxyphenyl)-1,3,4-oxadiazoleJ. L. 512Fenadiazole [INN:DCF]Fenadiazol [INN-Spanish]Fenadiazolum [INN-Latin]NSC 100729UNII-8YX6HIZ0IP8YX6HIZ0IP1,3,4-Oxadiazole, 2-(o-hydroxyphenyl)-JL-512NSC-100729BRN 0136925FENADIAZOLE [MI]FENADIAZOLE [INN]o-1,3,4-Oxodiazol-2-ylphenol
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:134791

fenadiazole

A biaryl that is phenol which is substituted at position 2 by a 1,3,4-oxadiazol-2-yl group. Formerly used as a hypnotic drug.

Formula
C8H6N2O2
Average mass
162.148 g/mol
Monoisotopic mass
162.04293 Da
Formal charge
0
  • 1,3,4-oxadiazoles — is a (CHEBI:46810)
  • phenols — is a (CHEBI:33853)
  • biaryl — is a (CHEBI:64459)
  • sedative — has role (CHEBI:35717)
  • sedative — has role (CHEBI:35717)
  • 1,3,4-oxadiazoles — is a (CHEBI:46810)
  • phenols — is a (CHEBI:33853)
  • biaryl — is a (CHEBI:64459)
Additional curated names
2-(1,3,4-oxadiazol-2-yl)phenol2-(o-hydroxyphenyl)-1,3,4-oxadiazoleo-1,3,4-oxadiazol-2-ylphenolJL 512JL-512NSC-100729
Cross-references from this source
  • CAS: 1008-65-7 — ChemIDplus
  • CAS: 1008-65-7 — DrugCentral
  • MANUAL_X_REF: 3745 — DrugCentral
  • MANUAL_X_REF: Fenadiazole — Wikipedia

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2019-01-10. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match13883

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (16.7%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (83.3%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (83.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (83.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 6 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Fenadiazole (INN)

Chemical / IUPAC name

Phenol, 2-(1,3,4-oxadiazol-2-yl)-

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
1008-65-7
EC
—
Annex
II
Entry number
208

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 213
Nearby record in the same annex

Iodine

CAS: 7553-56-2
EC: 231-442-4

What Annex II means for Fenadiazole (INN)

Fenadiazole (INN) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Fenadiazole (INN) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 1008-65-7 is the unique numerical identifier assigned to Fenadiazole (INN) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Fenadiazole (INN)

This page summarizes one Annex II record for Fenadiazole (INN) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Fenadiazole (INN), but confirm any final regulatory decision against the current official annex wording and source files.

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