Sympathicomimetic amines acting on the central nervous system: any substance contained in the first list of medicaments which are subject to medical prescription and referred to in Resolution AP (69) 2 of the Council of Europe
Sympathicomimetic amines acting on the central nervous system: any substance contained in the first list of medicaments which are subject to medical prescription and referred to in Resolution AP (69) 2 of the Council of Europe is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Chemical identity and properties
Amphetamine
1-phenylpropan-2-amine is a primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group. — ChEBI
- IUPAC name
- 1-phenylpropan-2-amine
- Molecular formula
- C9H13N
- Molecular weight
- 135.21 g/mol
- Exact mass
- 135.104799419 Da
- XLogP3
- 1.8
- Topological polar surface area
- 26.0 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 1
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
Sympathicomimetic amines acting on the central nervous system: any substance contained in the first list of medicaments which are subject to medical prescription and referred to in Resolution AP (69) 2 of the Council of Europe
Regulatory information
Key data
Inventory links for Sympathicomimetic amines acting on the central nervous system: any substance contained in the first list of medicaments which are subject to medical prescription and referred to in Resolution AP (69) 2 of the Council of Europe
Related records for Sympathicomimetic amines acting on the central nervous system: any substance contained in the first list of medicaments which are subject to medical prescription and referred to in Resolution AP (69) 2 of the Council of Europe
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
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What Annex II means for Sympathicomimetic amines acting on the central nervous system: any substance contained in the first list of medicaments which are subject to medical prescription and referred to in Resolution AP (69) 2 of the Council of Europe
Sympathicomimetic amines acting on the central nervous system: any substance contained in the first list of medicaments which are subject to medical prescription and referred to in Resolution AP (69) 2 of the Council of Europe is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
This record is linked to 11 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
Frequently asked questions
Source note for Annex II record Sympathicomimetic amines acting on the central nervous system: any substance contained in the first list of medicaments which are subject to medical prescription and referred to in Resolution AP (69) 2 of the Council of Europe
This page summarizes one Annex II record for Sympathicomimetic amines acting on the central nervous system: any substance contained in the first list of medicaments which are subject to medical prescription and referred to in Resolution AP (69) 2 of the Council of Europe from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for Sympathicomimetic amines acting on the central nervous system: any substance contained in the first list of medicaments which are subject to medical prescription and referred to in Resolution AP (69) 2 of the Council of Europe, but confirm any final regulatory decision against the current official annex wording and source files.
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