Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
Annex II Entry 18 15/10/2010

Allyl isothiocyanate

Allyl isothiocyanate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

Search similar Back to annex Compare
Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 18

Chemical identity and properties

PubChem 2D chemical structure for CAS 57-06-7
CAS 57-06-7PubChem CID 5971

Allyl Isothiocyanate

Allyl isothiocyanate is an isothiocyanate with the formula CH2=CHCH2N=C=S. A colorless oil with boiling point 152C, it is responsible for the pungent taste of mustard, horseradish, and wasabi. It has a role as a metabolite, an antimicrobial agent, an antineoplastic agent, an apoptosis inducer and a lachrymator. It is an alkenyl isothiocyanate and an isothiocyanate. — ChEBI

IUPAC name
3-isothiocyanatoprop-1-ene
Molecular formula
C4H5NS
Molecular weight
99.16 g/mol
Exact mass
99.01427034 Da
XLogP3
2.4
Topological polar surface area
44.5 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

AITCRedskinAllylsenfoelAllylsenevolOleum sinapisAllyl isosulfocyanateAllylsevenolumSenfoel
16 more reported names
3-Isothiocyanato-1-propene2-Propenyl isothiocyanateAllyspolCarbospol1-Propene, 3-isothiocyanato-Senf oelOleum sinapis volatileIsothiocyanate d'allyleAllyl sevenolumIsothiocyanic acid allyl esterAllyspol 75ECAllyl thioisocyanateAllyl isosulphocyanateFEMA No. 2034IsothiocyansaeureallylesterNCI-C50464
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Allyl isothiocyanate

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
57-06-7
EC
200-309-2
Annex
II
Entry number
18

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Allyl isothiocyanate

Allyl isothiocyanate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Allyl isothiocyanate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 57-06-7 is the unique numerical identifier assigned to Allyl isothiocyanate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Open INCI Checker

Source note for Annex II record Allyl isothiocyanate

This page summarizes one Annex II record for Allyl isothiocyanate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Allyl isothiocyanate, but confirm any final regulatory decision against the current official annex wording and source files.

View sourcesView updates

Tools & next steps

Check your formula

Paste a full INCI list to detect Allyl isothiocyanate and other flagged EU annex records in one pass.

INCI Checker

Compare entries

Compare Allyl isothiocyanate side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Compare

Browse the annex

See all records in Annex II and compare regulatory conditions across substances in this annex.

Open Annex II