Why does CAS 4008-48-4 appear in more than one EU cosmetic annex?

A substance identified by CAS 4008-48-4 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 4008-48-4?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 4008-48-4 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 4008-48-4

Q: How do I use CAS 4008-48-4 for compliance screening?

Cross-reference CAS 4008-48-4 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 4008-48-4 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 4008-48-4

CAS 4008-48-4PubChem CID 19910

Nitroxoline

Nitroxoline is a monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5. It has a role as an antimicrobial agent, an antiinfective agent, an antifungal agent and a renal agent. It is a C-nitro compound and a monohydroxyquinoline. — ChEBI

IUPAC name: 5-nitroquinolin-8-ol

Molecular formula: C9H6N2O3
Molecular weight: 190.16 g/mol
Exact mass: 190.03784206 Da
XLogP3: 2.1
Topological polar surface area: 78.9 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

8-Hydroxy-5-nitroquinoline5-Nitro-8-quinolinol5-Nitro-8-hydroxyquinoline5-Nitrox5-NOK5-Nitro-8-oxyquinolineNitroxolina5NOK

16 more reported names

NitroxolinumNSC-74947A8M33244M6CHEBI:67121NiceneRefChem:166162223-662-4NitroxolinNoxibiolNibiolNoxin8-Quinolinol, 5-nitro-5-Nitroxine5-Nitroks5-Nitro-8-oxychinolineNitroxolinum [INN-Latin]

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:67121
ChEMBL:CHEMBL1454910
EPA DTXSID:DTXSID4046284
PubMed:31638783
PubMed:30939017
PubMed:30184207
PubMed:22728969
PubMed:22695927
PubMed:22391578
PubMed:22289336
PubMed:22073285
PubMed:21969860
PubMed:21899946
PubMed:21598397
PubMed:21384590

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 4008-48-4

1 total

Annex

Entry

209

Nitroxoline (INN) and its salts

223-662-4

How CAS 4008-48-4 is used on this site

CAS 4008-48-4 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 4008-48-4 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 4008-48-4 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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