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Annex II Entry 1743 18/06/2025

4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF

4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1743

Chemical identity and properties

PubChem 2D chemical structure for CAS 1478-61-1
CAS 1478-61-1PubChem CID 73864

bisphenol AF

Bisphenol AF is an organofluorine compound that is bisphenol A with its methyl hydrogens replaced by fluorines. It has a role as a metabolite. It is a bisphenol and an organofluorine compound. It is functionally related to a bisphenol A. — ChEBI

IUPAC name
4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenol
Molecular formula
C15H10F6O2
Molecular weight
336.23 g/mol
Exact mass
336.05849853 Da
XLogP3
4.5
Topological polar surface area
40.5 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
8
Covalent units
1
Defined stereocentres
0

Also known as

2,2-Bis(4-hydroxyphenyl)hexafluoropropaneHexafluorobisphenol a4,4'-(Hexafluoroisopropylidene)diphenolBiphenol AF2,2-Bis(4-hydroxyphenyl)perfluoropropaneHexafluorodiphenylolpropaneHexafluoroacetone bisphenol AHexafluoroisopropylidenebis(4-hydroxybenzene)
16 more reported names
4,4'-(1,1,1,3,3,3-Hexafluoropropane-2,2-diyl)diphenol2,2-Bis-(p-hydroxyphenyl)-hexafluoropropanePhenol, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis-OH7IX8A37JCHEBI:72754CURATIVE 30NSC-152522Phenol, 4,4'-(2,2,2-trifluoro-1-(trifluoromethyl)ethylidene)bis-1,1,1,3,3,3-hexafluoro-2,2-bis(4-hydroxyphenyl)propane2,2-bis(4'-hydroxyphenyl)hexafluoropropaneBPAF compound4-(1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl)phenol4,4'-hexafluorisopropylidene diphenolRefChem:120502216-036-74,4'-(perfluoropropane-2,2-diyl)diphenol
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF

Regulatory information

Regulation

(EU) 2025/877

See every entry this act set

Key data

CAS
1478-61-1
EC
216-036-7
Annex
II
Entry number
1743

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1741
Nearby record in the same annex

dibutyltin oxide

CAS: 818-08-6
EC: 212-449-1

What Annex II means for 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF

4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 1478-61-1 is the unique numerical identifier assigned to 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF

This page summarizes one Annex II record for 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF, but confirm any final regulatory decision against the current official annex wording and source files.

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