Why does CAS 1478-61-1 appear in more than one EU cosmetic annex?

A substance identified by CAS 1478-61-1 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 1478-61-1?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 1478-61-1 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 1478-61-1

Q: How do I use CAS 1478-61-1 for compliance screening?

Cross-reference CAS 1478-61-1 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 1478-61-1 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 1478-61-1

CAS 1478-61-1PubChem CID 73864

bisphenol AF

Bisphenol AF is an organofluorine compound that is bisphenol A with its methyl hydrogens replaced by fluorines. It has a role as a metabolite. It is a bisphenol and an organofluorine compound. It is functionally related to a bisphenol A. — ChEBI

IUPAC name: 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenol

Molecular formula: C15H10F6O2
Molecular weight: 336.23 g/mol
Exact mass: 336.05849853 Da
XLogP3: 4.5
Topological polar surface area: 40.5 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 8
Covalent units: 1
Defined stereocentres: 0

Also known as

2,2-Bis(4-hydroxyphenyl)hexafluoropropaneHexafluorobisphenol a4,4'-(Hexafluoroisopropylidene)diphenolBiphenol AF2,2-Bis(4-hydroxyphenyl)perfluoropropaneHexafluorodiphenylolpropaneHexafluoroacetone bisphenol AHexafluoroisopropylidenebis(4-hydroxybenzene)

16 more reported names

4,4'-(1,1,1,3,3,3-Hexafluoropropane-2,2-diyl)diphenol2,2-Bis-(p-hydroxyphenyl)-hexafluoropropanePhenol, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis-OH7IX8A37JCHEBI:72754CURATIVE 30NSC-152522Phenol, 4,4'-(2,2,2-trifluoro-1-(trifluoromethyl)ethylidene)bis-1,1,1,3,3,3-hexafluoro-2,2-bis(4-hydroxyphenyl)propane2,2-bis(4'-hydroxyphenyl)hexafluoropropaneBPAF compound4-(1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl)phenol4,4'-hexafluorisopropylidene diphenolRefChem:120502216-036-74,4'-(perfluoropropane-2,2-diyl)diphenol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:72754
ChEMBL:CHEMBL1900054
EPA DTXSID:DTXSID7037717
PubMed:40623864
PubMed:40531193
PubMed:40513842
PubMed:40089166
PubMed:39938710
PubMed:39151878
PubMed:39087390
PubMed:39059691
PubMed:38761188
PubMed:38643640
PubMed:38133387
PubMed:38043716

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 1478-61-1

1 total

Annex

Entry

1743

4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF

216-036-7

How CAS 1478-61-1 is used on this site

CAS 1478-61-1 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 1478-61-1 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 1478-61-1 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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